Jianwei Zheng

Yitong Lin, Jiaying He, Jiahe Chen et al.

Motivation: Biomedical knowledge graphs (KGs) are crucial for drug discovery and disease understanding, yet their completion and reasoning are challenging. Knowledge Embedding (KE) methods capture global semantics but struggle with dynamic structural integration, while Graph Neural Networks (GNNs) excel locally but often lack semantic understanding. Even ensemble approaches, including those leveraging language models, often fail to achieve a deep, adaptive, and synergistic co-evolution between semantic comprehension and structural learning. Addressing this critical gap in fostering continuous, reciprocal refinement between these two aspects in complex biomedical KGs is paramount. Results: We introduce BioGraphFusion, a novel framework for deeply synergistic semantic and structural learning. BioGraphFusion establishes a global semantic foundation via tensor decomposition, guiding an LSTM-driven mechanism to dynamically refine relation embeddings during graph propagation. This fosters adaptive interplay between semantic understanding and structural learning, further enhanced by query-guided subgraph construction and a hybrid scoring mechanism. Experiments across three key biomedical tasks demonstrate BioGraphFusion's superior performance over state-of-the-art KE, GNN, and ensemble models. A case study on Cutaneous Malignant Melanoma 1 (CMM1) highlights its ability to unveil biologically meaningful pathways. Availability and Implementation: Source code and all training data are freely available for download at https://github.com/Y-TARL/BioGraphFusion. Supplementary information: Supplementary data are available at Bioinformatics online.

Yibin Wang, Weizhong Zhang, Jianwei Zheng et al.

Image composition involves seamlessly integrating given objects into a specific visual context. Current training-free methods rely on composing attention weights from several samplers to guide the generator. However, since these weights are derived from disparate contexts, their combination leads to coherence confusion and loss of appearance information. These issues worsen with their excessive focus on background generation, even when unnecessary in this task. This not only impedes their swift implementation but also compromises foreground generation quality. Moreover, these methods introduce unwanted artifacts in the transition area. In this paper, we formulate image composition as a subject-based local editing task, solely focusing on foreground generation. At each step, the edited foreground is combined with the noisy background to maintain scene consistency. To address the remaining issues, we propose PrimeComposer, a faster training-free diffuser that composites the images by well-designed attention steering across different noise levels. This steering is predominantly achieved by our Correlation Diffuser, utilizing its self-attention layers at each step. Within these layers, the synthesized subject interacts with both the referenced object and background, capturing intricate details and coherent relationships. This prior information is encoded into the attention weights, which are then integrated into the self-attention layers of the generator to guide the synthesis process. Besides, we introduce a Region-constrained Cross-Attention to confine the impact of specific subject-related tokens to desired regions, addressing the unwanted artifacts shown in the prior method thereby further improving the coherence in the transition area. Our method exhibits the fastest inference efficiency and extensive experiments demonstrate our superiority both qualitatively and quantitatively.