Danilo Danese

Danilo Danese, Angela Lombardi, Matteo Attimonelli et al.

Brain Magnetic Resonance Imaging (MRI) plays a central role in studying neurological development, aging, and diseases. One key application is Brain Age Prediction (BAP), which estimates an individual's biological brain age from MRI data. Effective BAP models require large, diverse, and age-balanced datasets, whereas existing 3D MRI datasets are demographically skewed, limiting fairness and generalizability. Acquiring new data is costly and ethically constrained, motivating generative data augmentation. Current generative methods are often based on latent diffusion models, which operate in learned low dimensional latent spaces to address the memory demands of volumetric MRI data. However, these methods are typically slow at inference, may introduce artifacts due to latent compression, and are rarely conditioned on age, thereby affecting the BAP performance. In this work, we propose FlowLet, a conditional generative framework that synthesizes age-conditioned 3D MRIs by leveraging flow matching within an invertible 3D wavelet domain, helping to avoid reconstruction artifacts and reducing computational demands. Experiments show that FlowLet generates high-fidelity volumes with few sampling steps. Training BAP models with data generated by FlowLet improves performance for underrepresented age groups, and region-based analysis confirms preservation of anatomical structures.

Claudio Pomo, Matteo Attimonelli, Danilo Danese et al.

Multimodal Recommender Systems aim to improve recommendation accuracy by integrating heterogeneous content, such as images and textual metadata. While effective, it remains unclear whether their gains stem from true multimodal understanding or increased model complexity. This work investigates the role of multimodal item embeddings, emphasizing the semantic informativeness of the representations. Initial experiments reveal that embeddings from standard extractors (e.g., ResNet50, Sentence-Bert) enhance performance, but rely on modality-specific encoders and ad hoc fusion strategies that lack control over cross-modal alignment. To overcome these limitations, we leverage Large Vision-Language Models (LVLMs) to generate multimodal-by-design embeddings via structured prompts. This approach yields semantically aligned representations without requiring any fusion. Experiments across multiple settings show notable performance improvements. Furthermore, LVLMs embeddings offer a distinctive advantage: they can be decoded into structured textual descriptions, enabling direct assessment of their multimodal comprehension. When such descriptions are incorporated as side content into recommender systems, they improve recommendation performance, empirically validating the semantic depth and alignment encoded within LVLMs outputs. Our study highlights the importance of semantically rich representations and positions LVLMs as a compelling foundation for building robust and meaningful multimodal representations in recommendation tasks.