Junhan Zhao

Yuqi Zhang, Bo Fang, Yuxin Yang et al.

Predicting the structure of short peptides in protein binding pockets remains difficult because this regime requires physics-based conformational search, yet existing methods do not provide a practical way to carry out that search on current hardware. We present QSAD, a quantum-classical framework that reformulates peptide structure prediction as amino-acid-level Hamiltonian sampling and replaces iterative optimization with non-iterative Hamiltonian evolution. Executed entirely on IBM Heron R2 across 101 binding-pocket peptides (5-18 residues), QSAD improves prediction accuracy by 27-71% over all evaluated AI and quantum baselines while maintaining the lowest variance across tested lengths. QSAD also tolerates noise levels 3-5x beyond typical hardware error rates, where iterative methods fail, and reduces mean quantum execution time by 27x relative to VQE. The sampled ensemble further supports approximate reconstruction of protein energy landscapes. These results establish coarse-grained quantum sampling as a practical computational path for structure prediction in regimes where data-driven methods lack sufficient signal.

Fei Kong, Xiyue Wang, Jinxi Xiang et al.

Artificial intelligence (AI) holds significant promise in transforming medical imaging, enhancing diagnostics, and refining treatment strategies. However, the reliance on extensive multicenter datasets for training AI models poses challenges due to privacy concerns. Federated learning provides a solution by facilitating collaborative model training across multiple centers without sharing raw data. This study introduces a federated attention-consistent learning (FACL) framework to address challenges associated with large-scale pathological images and data heterogeneity. FACL enhances model generalization by maximizing attention consistency between local clients and the server model. To ensure privacy and validate robustness, we incorporated differential privacy by introducing noise during parameter transfer. We assessed the effectiveness of FACL in cancer diagnosis and Gleason grading tasks using 19,461 whole-slide images of prostate cancer from multiple centers. In the diagnosis task, FACL achieved an area under the curve (AUC) of 0.9718, outperforming seven centers with an average AUC of 0.9499 when categories are relatively balanced. For the Gleason grading task, FACL attained a Kappa score of 0.8463, surpassing the average Kappa score of 0.7379 from six centers. In conclusion, FACL offers a robust, accurate, and cost-effective AI training model for prostate cancer pathology while maintaining effective data safeguards.

Liqi Yan, Qifan Wang, Junhan Zhao et al.

First-Person-View (FPV) holds immense potential for revolutionizing the trajectory of Unmanned Aerial Vehicles (UAVs), offering an exhilarating avenue for navigating complex building structures. Yet, traditional Neural Radiance Field (NeRF) methods face challenges such as sampling single points per iteration and requiring an extensive array of views for supervision. UAV videos exacerbate these issues with limited viewpoints and significant spatial scale variations, resulting in inadequate detail rendering across diverse scales. In response, we introduce FPV-NeRF, addressing these challenges through three key facets: (1) Temporal consistency. Leveraging spatio-temporal continuity ensures seamless coherence between frames; (2) Global structure. Incorporating various global features during point sampling preserves space integrity; (3) Local granularity. Employing a comprehensive framework and multi-resolution supervision for multi-scale scene feature representation tackles the intricacies of UAV video spatial scales. Additionally, due to the scarcity of publicly available FPV videos, we introduce an innovative view synthesis method using NeRF to generate FPV perspectives from UAV footage, enhancing spatial perception for drones. Our novel dataset spans diverse trajectories, from outdoor to indoor environments, in the UAV domain, differing significantly from traditional NeRF scenarios. Through extensive experiments encompassing both interior and exterior building structures, FPV-NeRF demonstrates a superior understanding of the UAV flying space, outperforming state-of-the-art methods in our curated UAV dataset. Explore our project page for further insights: https://fpv-nerf.github.io/.

Kecheng Zhang, Zongxin Yang, Mingfei Han et al.

Visual agents operating in the wild must respond to queries precisely when sufficient evidence first appears in a video stream, a critical capability that is overlooked by conventional video LLMs evaluated in offline settings. The shift to an online, streaming paradigm introduces significant challenges: a lack of decision transparency, the difficulty of aligning response timing with visual evidence, and the need to maintain a global, causally consistent understanding under tight computational budgets. To address these issues, we propose a novel framework that decouples reasoning control from memory integration. We introduce \textbf{\model{}}, an instantiation of this framework with two core components. First, the \emph{Active Thinking Decision Maker (ATDM)} is a transparent reasoning controller that externalizes its decision process using observable progress ($\boldsymbolρ$) and confidence ($\boldsymbol{c}$) metrics. This allows it to precisely time its response $t_r$ to match the first-sufficient-evidence timestamp $t^\star$ while streaming its reasoning to the user. Second, the \emph{Hierarchical Progressive Semantic Integration (HPSI)} module acts as an efficient memory system. It employs a set of learnable, multi-level aggregation tokens that are propagated across clips to build a rich, global cognitive state without exceeding token budgets. %Our approach sets a new standard on key online video understanding benchmarks, achieving strong performance of \textbf{71.6\%} on StreamingBench and \textbf{46.9\%} on OVOBench, demonstrating a robust solution for evidence-aligned and transparent online video analysis. Extensive experiments demonstrate the effectiveness of ATDM and HPSI, e.g., Thinking-QwenVL improves the accuracy of the previous state-of-the-art from 67.63\% to 71.60\% on the StreamingBench benchmark.

Xiang Gao, Zhengbo Xu, Junhan Zhao et al.

Recently, large-scale text-to-image (T2I) diffusion models have emerged as a powerful tool for image-to-image translation (I2I), allowing open-domain image translation via user-provided text prompts. This paper proposes frequency-controlled diffusion model (FCDiffusion), an end-to-end diffusion-based framework that contributes a novel solution to text-guided I2I from a frequency-domain perspective. At the heart of our framework is a feature-space frequency-domain filtering module based on Discrete Cosine Transform, which filters the latent features of the source image in the DCT domain, yielding filtered image features bearing different DCT spectral bands as different control signals to the pre-trained Latent Diffusion Model. We reveal that control signals of different DCT spectral bands bridge the source image and the T2I generated image in different correlations (e.g., style, structure, layout, contour, etc.), and thus enable versatile I2I applications emphasizing different I2I correlations, including style-guided content creation, image semantic manipulation, image scene translation, and image style translation. Different from related approaches, FCDiffusion establishes a unified text-guided I2I framework suitable for diverse image translation tasks simply by switching among different frequency control branches at inference time. The effectiveness and superiority of our method for text-guided I2I are demonstrated with extensive experiments both qualitatively and quantitatively. Our project is publicly available at: https://xianggao1102.github.io/FCDiffusion/.

Xinyue Zeng, Tuo Wang, Adithya Kulkarni et al.

Recent advances in protein structure prediction have achieved near-atomic accuracy for well-folded proteins. However, current benchmarks inadequately assess model performance in biologically challenging contexts, especially those involving intrinsically disordered regions (IDRs), limiting their utility in applications such as drug discovery, disease variant interpretation, and protein interface design. We introduce DisProtBench, a comprehensive benchmark for evaluating protein structure prediction models (PSPMs) under structural disorder and complex biological conditions. DisProtBench spans three key axes: (1) Data complexity, covering disordered regions, G protein-coupled receptor (GPCR) ligand pairs, and multimeric complexes; (2) Task diversity, benchmarking twelve leading PSPMs across structure-based tasks with unified classification, regression, and interface metrics; and (3) Interpretability, via the DisProtBench Portal, which provides precomputed 3D structures and visual error analyses. Our results reveal significant variability in model robustness under disorder, with low-confidence regions linked to functional prediction failures. Notably, global accuracy metrics often fail to predict task performance in disordered settings, emphasizing the need for function-aware evaluation. DisProtBench establishes a reproducible, extensible, and biologically grounded framework for assessing next-generation PSPMs in realistic biomedical scenarios.

Junhan Zhao, Xiang Liu, Chen Guo et al.

The multidimensional nature of spatial data poses a challenge for visualization. In this paper, we introduce Phoenixmap, a simple abstract visualization method to address the issue of visualizing multiple spatial distributions at once. The Phoenixmap approach starts by identifying the enclosed outline of the point collection, then assigns different widths to outline segments according to the segments' corresponding inside regions. Thus, one 2D distribution is represented as an outline with varied thicknesses. Phoenixmap is capable of overlaying multiple outlines and comparing them across categories of objects in a 2D space. We chose heatmap as a benchmark spatial visualization method and conducted user studies to compare performances among Phoenixmap, heatmap, and dot distribution map. Based on the analysis and participant feedback, we demonstrate that Phoenixmap 1) allows users to perceive and compare spatial distribution data efficiently; 2) frees up graphics space with a concise form that can provide visualization design possibilities like overlapping; and 3) provides a good quantitative perceptual estimating capability given the proper legends. Finally, we discuss several possible applications of Phoenixmap and present one visualization of multiple species of birds' active regions in a nature preserve.

Hongxiao Bai, Hai Zhao, Junhan Zhao

Implicit discourse relation recognition is a challenging task due to the absence of the necessary informative clue from explicit connectives. The prediction of relations requires a deep understanding of the semantic meanings of sentence pairs. As implicit discourse relation recognizer has to carefully tackle the semantic similarity of the given sentence pairs and the severe data sparsity issue exists in the meantime, it is supposed to be beneficial from mastering the entire training data. Thus in this paper, we propose a novel memory mechanism to tackle the challenges for further performance improvement. The memory mechanism is adequately memorizing information by pairing representations and discourse relations of all training instances, which right fills the slot of the data-hungry issue in the current implicit discourse relation recognizer. Our experiments show that our full model with memorizing the entire training set reaches new state-of-the-art against strong baselines, which especially for the first time exceeds the milestone of 60% accuracy in the 4-way task.