Shiman Li

Shiman Li, Haoran Wang, Yucong Meng et al.

Precise delineation of multiple organs or abnormal regions in the human body from medical images plays an essential role in computer-aided diagnosis, surgical simulation, image-guided interventions, and especially in radiotherapy treatment planning. Thus, it is of great significance to explore automatic segmentation approaches, among which deep learning-based approaches have evolved rapidly and witnessed remarkable progress in multi-organ segmentation. However, obtaining an appropriately sized and fine-grained annotated dataset of multiple organs is extremely hard and expensive. Such scarce annotation limits the development of high-performance multi-organ segmentation models but promotes many annotation-efficient learning paradigms. Among these, studies on transfer learning leveraging external datasets, semi-supervised learning using unannotated datasets and partially-supervised learning integrating partially-labeled datasets have led the dominant way to break such dilemma in multi-organ segmentation. We first review the traditional fully supervised method, then present a comprehensive and systematic elaboration of the 3 abovementioned learning paradigms in the context of multi-organ segmentation from both technical and methodological perspectives, and finally summarize their challenges and future trends.

Haoran Wang, Qiuye Jin, Shiman Li et al.

Deep learning has achieved widespread success in medical image analysis, leading to an increasing demand for large-scale expert-annotated medical image datasets. Yet, the high cost of annotating medical images severely hampers the development of deep learning in this field. To reduce annotation costs, active learning aims to select the most informative samples for annotation and train high-performance models with as few labeled samples as possible. In this survey, we review the core methods of active learning, including the evaluation of informativeness and sampling strategy. For the first time, we provide a detailed summary of the integration of active learning with other label-efficient techniques, such as semi-supervised, self-supervised learning, and so on. We also summarize active learning works that are specifically tailored to medical image analysis. Additionally, we conduct a thorough comparative analysis of the performance of different AL methods in medical image analysis with experiments. In the end, we offer our perspectives on the future trends and challenges of active learning and its applications in medical image analysis.

Shiman Li, Jiayue Zhao, Shaolei Liu et al.

Deep learning-based medical image segmentation helps assist diagnosis and accelerate the treatment process while the model training usually requires large-scale dense annotation datasets. Weakly semi-supervised medical image segmentation is an essential application because it only requires a small amount of scribbles and a large number of unlabeled data to train the model, which greatly reduces the clinician's effort to fully annotate images. To handle the inadequate supervisory information challenge in weakly semi-supervised segmentation (WSSS), a SuperPixel-Propagated Pseudo-label (SP${}^3$) learning method is proposed, using the structural information contained in superpixel for supplemental information. Specifically, the annotation of scribbles is propagated to superpixels and thus obtains a dense annotation for supervised training. Since the quality of pseudo-labels is limited by the low-quality annotation, the beneficial superpixels selected by dynamic thresholding are used to refine pseudo-labels. Furthermore, aiming to alleviate the negative impact of noise in pseudo-label, superpixel-level uncertainty is incorporated to guide the pseudo-label supervision for stable learning. Our method achieves state-of-the-art performance on both tumor and organ segmentation datasets under the WSSS setting, using only 3\% of the annotation workload compared to fully supervised methods and attaining approximately 80\% Dice score. Additionally, our method outperforms eight weakly and semi-supervised methods under both weakly supervised and semi-supervised settings. Results of extensive experiments validate the effectiveness and annotation efficiency of our weakly semi-supervised segmentation, which can assist clinicians in achieving automated segmentation for organs or tumors quickly and ultimately benefit patients.