Lanzhuju Mei

Yu Fang, Lanzhuju Mei, Changjian Li et al.

Cone beam computed tomography (CBCT) has been widely used in clinical practice, especially in dental clinics, while the radiation dose of X-rays when capturing has been a long concern in CBCT imaging. Several research works have been proposed to reconstruct high-quality CBCT images from sparse-view 2D projections, but the current state-of-the-arts suffer from artifacts and the lack of fine details. In this paper, we propose SNAF for sparse-view CBCT reconstruction by learning the neural attenuation fields, where we have invented a novel view augmentation strategy to overcome the challenges introduced by insufficient data from sparse input views. Our approach achieves superior performance in terms of high reconstruction quality (30+ PSNR) with only 20 input views (25 times fewer than clinical collections), which outperforms the state-of-the-arts. We have further conducted comprehensive experiments and ablation analysis to validate the effectiveness of our approach.

Yulong Dou, Lanzhuju Mei, Dinggang Shen et al.

Orthodontics focuses on rectifying misaligned teeth (i.e., malocclusions), affecting both masticatory function and aesthetics. However, orthodontic treatment often involves complex, lengthy procedures. As such, generating a 2D photograph depicting aligned teeth prior to orthodontic treatment is crucial for effective dentist-patient communication and, more importantly, for encouraging patients to accept orthodontic intervention. In this paper, we propose a 3D structure-guided tooth alignment network that takes 2D photographs as input (e.g., photos captured by smartphones) and aligns the teeth within the 2D image space to generate an orthodontic comparison photograph featuring aesthetically pleasing, aligned teeth. Notably, while the process operates within a 2D image space, our method employs 3D intra-oral scanning models collected in clinics to learn about orthodontic treatment, i.e., projecting the pre- and post-orthodontic 3D tooth structures onto 2D tooth contours, followed by a diffusion model to learn the mapping relationship. Ultimately, the aligned tooth contours are leveraged to guide the generation of a 2D photograph with aesthetically pleasing, aligned teeth and realistic textures. We evaluate our network on various facial photographs, demonstrating its exceptional performance and strong applicability within the orthodontic industry.

Jiuli Xiong, Lanzhuju Mei, Jiameng Liu et al.

Accurate lymph node detection and quantification are crucial for cancer diagnosis and staging on contrast-enhanced CT images, as they impact treatment planning and prognosis. However, detecting lymph nodes in the mediastinal area poses challenges due to their low contrast, irregular shapes and dispersed distribution. In this paper, we propose a Swin-Det Fusion Network (SDF-Net) to effectively detect lymph nodes. SDF-Net integrates features from both segmentation and detection to enhance the detection capability of lymph nodes with various shapes and sizes. Specifically, an auto-fusion module is designed to merge the feature maps of segmentation and detection networks at different levels. To facilitate effective learning without mask annotations, we introduce a shape-adaptive Gaussian kernel to represent lymph node in the training stage and provide more anatomical information for effective learning. Comparative results demonstrate promising performance in addressing the complex lymph node detection problem.

Han Wu, Chong Wang, Lanzhuju Mei et al.

Automated cephalometric landmark detection is crucial in real-world orthodontic diagnosis. Current studies mainly focus on only adult subjects, neglecting the clinically crucial scenario presented by adolescents whose landmarks often exhibit significantly different appearances compared to adults. Hence, an open question arises about how to develop a unified and effective detection algorithm across various age groups, including adolescents and adults. In this paper, we propose CeLDA, the first work for Cephalometric Landmark Detection across Ages. Our method leverages a prototypical network for landmark detection by comparing image features with landmark prototypes. To tackle the appearance discrepancy of landmarks between age groups, we design new strategies for CeLDA to improve prototype alignment and obtain a holistic estimation of landmark prototypes from a large set of training images. Moreover, a novel prototype relation mining paradigm is introduced to exploit the anatomical relations between the landmark prototypes. Extensive experiments validate the superiority of CeLDA in detecting cephalometric landmarks on both adult and adolescent subjects. To our knowledge, this is the first effort toward developing a unified solution and dataset for cephalometric landmark detection across age groups. Our code and dataset will be made public on https://github.com/ShanghaiTech-IMPACT/Cephalometric-Landmark-Detection-across-Ages-with-Prototypical-Network

Ibrahim Ethem Hamamci, Sezgin Er, Omer Faruk Durugol et al.

Panoramic X-rays are frequently used in dentistry for treatment planning, but their interpretation can be both time-consuming and prone to error. Artificial intelligence (AI) has the potential to aid in the analysis of these X-rays, thereby improving the accuracy of dental diagnoses and treatment plans. Nevertheless, designing automated algorithms for this purpose poses significant challenges, mainly due to the scarcity of annotated data and variations in anatomical structure. To address these issues, we organized the Dental Enumeration and Diagnosis on Panoramic X-rays Challenge (DENTEX) in association with the International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI) in 2023. This challenge aims to promote the development of algorithms for multi-label detection of abnormal teeth, using three types of hierarchically annotated data: partially annotated quadrant data, partially annotated quadrant-enumeration data, and fully annotated quadrant-enumeration-diagnosis data, inclusive of four different diagnoses. In this paper, we present a comprehensive analysis of the methods and results from the challenge. Our findings reveal that top performers succeeded through diverse, specialized strategies, from segmentation-guided pipelines to highly-engineered single-stage detectors, using advanced Transformer and diffusion models. These strategies significantly outperformed traditional approaches, particularly for the challenging tasks of tooth enumeration and subtle disease classification. By dissecting the architectural choices that drove success, this paper provides key insights for future development of AI-powered tools that can offer more precise and efficient diagnosis and treatment planning in dentistry. The evaluation code and datasets can be accessed at https://github.com/ibrahimethemhamamci/DENTEX

Zihao Zhao, Sheng Wang, Jinchen Gu et al.

The integration of Computer-Aided Diagnosis (CAD) with Large Language Models (LLMs) presents a promising frontier in clinical applications, notably in automating diagnostic processes akin to those performed by radiologists and providing consultations similar to a virtual family doctor. Despite the promising potential of this integration, current works face at least two limitations: (1) From the perspective of a radiologist, existing studies typically have a restricted scope of applicable imaging domains, failing to meet the diagnostic needs of different patients. Also, the insufficient diagnostic capability of LLMs further undermine the quality and reliability of the generated medical reports. (2) Current LLMs lack the requisite depth in medical expertise, rendering them less effective as virtual family doctors due to the potential unreliability of the advice provided during patient consultations. To address these limitations, we introduce ChatCAD+, to be universal and reliable. Specifically, it is featured by two main modules: (1) Reliable Report Generation and (2) Reliable Interaction. The Reliable Report Generation module is capable of interpreting medical images from diverse domains and generate high-quality medical reports via our proposed hierarchical in-context learning. Concurrently, the interaction module leverages up-to-date information from reputable medical websites to provide reliable medical advice. Together, these designed modules synergize to closely align with the expertise of human medical professionals, offering enhanced consistency and reliability for interpretation and advice. The source code is available at https://github.com/zhaozh10/ChatCAD.