Md Zakir Hossain

Xuehan Liu, Md Rakibul Hasan, Tom Gedeon et al.

In response to the global need for efficient early diagnosis of Autism Spectrum Disorder (ASD), this paper bridges the gap between traditional, time-consuming diagnostic methods and potential automated solutions. We propose a multi-atlas deep ensemble network, MADE-for-ASD, that integrates multiple atlases of the brain's functional magnetic resonance imaging (fMRI) data through a weighted deep ensemble network. Our approach integrates demographic information into the prediction workflow, which enhances ASD diagnosis performance and offers a more holistic perspective on patient profiling. We experiment with the well-known publicly available ABIDE (Autism Brain Imaging Data Exchange) I dataset, consisting of resting state fMRI data from 17 different laboratories around the globe. Our proposed system achieves 75.20% accuracy on the entire dataset and 96.40% on a specific subset $-$ both surpassing reported ASD diagnosis accuracy in ABIDE I fMRI studies. Specifically, our model improves by 4.4 percentage points over prior works on the same amount of data. The model exhibits a sensitivity of 82.90% and a specificity of 69.70% on the entire dataset, and 91.00% and 99.50%, respectively, on the specific subset. We leverage the F-score to pinpoint the top 10 ROI in ASD diagnosis, such as precuneus and anterior cingulate/ventromedial. The proposed system can potentially pave the way for more cost-effective, efficient and scalable strategies in ASD diagnosis. Codes and evaluations are publicly available at https://github.com/hasan-rakibul/MADE-for-ASD.

Yan Yang, Md Zakir Hossain, Eric A Stone et al.

Spatial transcriptomics (ST) is essential for understanding diseases and developing novel treatments. It measures gene expression of each fine-grained area (i.e., different windows) in the tissue slide with low throughput. This paper proposes an Exemplar Guided Network (EGN) to accurately and efficiently predict gene expression directly from each window of a tissue slide image. We apply exemplar learning to dynamically boost gene expression prediction from nearest/similar exemplars of a given tissue slide image window. Our EGN framework composes of three main components: 1) an extractor to structure a representation space for unsupervised exemplar retrievals; 2) a vision transformer (ViT) backbone to progressively extract representations of the input window; and 3) an Exemplar Bridging (EB) block to adaptively revise the intermediate ViT representations by using the nearest exemplars. Finally, we complete the gene expression prediction task with a simple attention-based prediction block. Experiments on standard benchmark datasets indicate the superiority of our approach when comparing with the past state-of-the-art (SOTA) methods.

Md Mehedi Hasan, Rafiqul Islam, Md Zakir Hossain

False data injection (FDI) attacks on Internet of Medical Things (IoMT) sensor streams falsify vital signs in transit, threatening patient safety and defeating clinical monitoring systems that lack cyber-physical anomaly detection capability. Existing deep learning detectors conflate inter-sensor spatial correlations with temporal dependencies in a shared latent space, preventing disentanglement of the distinct spatial and temporal signatures that FDI attacks imprint simultaneously; no current method exploits domain knowledge to constrain outputs against physiologically impossible attack patterns. We propose DSTAN-Med, a supervised framework comprising a Dual-channel Attention Mechanism (DAM) that routes multivariate sensor windows through independent sensor-wise (SWA) and time-wise (TWA) self-attention pathways operating on orthogonal tensor axes, a residual 1D-CNN block for local temporal feature extraction, and a zero-parameter Physiological Plausibility Filter (PPF) that suppresses attack signatures violating domain-knowledge bounds. Evaluated across three IoMT sensor datasets - PhysioNet/CinC 2012 (ICU vital signs), MIMIC-III Waveform (continuous ICU waveforms), and WESAD (wearable biosensor signals) - DSTAN-Med achieves mean sensitivity gains of 7.4-8.3 percentage points over the strongest Transformer baseline (TranAD), with improvements significant at p < 0.01 (McNemar's test, Holm-Bonferroni correction). The PPF contributes independent precision gains of 3.1-4.2 percentage points at negligible sensitivity cost across all three corpora. Ablation studies confirm that each component is individually necessary; removal of residual connections alone reduces sensitivity by 14.0 percentage points. The source code is publicly available at https://github.com/mehedi93hasan/DSTAN-MED.

Md Zakir Hossain, Md Ayshik Rahman Khan, Md Rafiqul Islam et al.

The growth of networked and IoT systems has intensified cyber-security threats and exposed the limits of traditional signature-based intrusion detection. Although machine-learning-based intrusion detection systems often report strong benchmark performance, high ac- curacy within a single dataset does not necessarily guarantee reliable performance in unseen network environments. This study investigates the generalisation capability of supervised machine learning models for intrusion detection using UNSW-NB15 and TON_IoT. Random Forest, Logistic Regression, and Naive Bayes were evaluated under same-dataset and cross-dataset settings. Random Forest achieved the strongest same dataset performance, with 95.08% accuracy on UNSW-NB15 and 99.79% on TON_IoT, but performance dropped sharply in cross-dataset testing. When trained on UNSW-NB15 and tested on TON_IoT or vice versa, below 40% accuracy. These results reveal a significant generalisation gap in intrusion detection. We connect this challenge to affective computing and human-centric AI, where behavioural signal analysis, anomaly detection, domain shift, and context-sensitive modelling are also central. This framing highlights the need for adaptive, generalisable cyber-security models that can operate across changing network and IoT environments.

Md. Tahrim Faroque, Yan Yang, Md Zakir Hossain et al.

Smile veracity classification is a task of interpreting social interactions. Broadly, it distinguishes between spontaneous and posed smiles. Previous approaches used hand-engineered features from facial landmarks or considered raw smile videos in an end-to-end manner to perform smile classification tasks. Feature-based methods require intervention from human experts on feature engineering and heavy pre-processing steps. On the contrary, raw smile video inputs fed into end-to-end models bring more automation to the process with the cost of considering many redundant facial features (beyond landmark locations) that are mainly irrelevant to smile veracity classification. It remains unclear to establish discriminative features from landmarks in an end-to-end manner. We present a MeshSmileNet framework, a transformer architecture, to address the above limitations. To eliminate redundant facial features, our landmarks input is extracted from Attention Mesh, a pre-trained landmark detector. Again, to discover discriminative features, we consider the relativity and trajectory of the landmarks. For the relativity, we aggregate facial landmark that conceptually formats a curve at each frame to establish local spatial features. For the trajectory, we estimate the movements of landmark composed features across time by self-attention mechanism, which captures pairwise dependency on the trajectory of the same landmark. This idea allows us to achieve state-of-the-art performances on UVA-NEMO, BBC, MMI Facial Expression, and SPOS datasets.

Md Rakibul Hasan, Md Zakir Hossain, Shreya Ghosh et al.

Empathy indicates an individual's ability to understand others. Over the past few years, empathy has drawn attention from various disciplines, including but not limited to Affective Computing, Cognitive Science, and Psychology. Detecting empathy has potential applications in society, healthcare and education. Despite being a broad and overlapping topic, the avenue of empathy detection leveraging Machine Learning remains underexplored from a systematic literature review perspective. We collected 849 papers from 10 well-known academic databases, systematically screened them and analysed the final 82 papers. Our analyses reveal several prominent task formulations - including empathy on localised utterances or overall expressions, unidirectional or parallel empathy, and emotional contagion - in monadic, dyadic and group interactions. Empathy detection methods are summarised based on four input modalities - text, audiovisual, audio and physiological signals - thereby presenting modality-specific network architecture design protocols. We discuss challenges, research gaps and potential applications in the Affective Computing-based empathy domain, which can facilitate new avenues of exploration. We further enlist the public availability of datasets and codes. This paper, therefore, provides a structured overview of recent advancements and remaining challenges towards developing a robust empathy detection system that could meaningfully contribute to enhancing human well-being.

Ramya Chandrasekar, Md Rakibul Hasan, Shreya Ghosh et al.

Anxiety is a common mental health condition characterised by excessive worry, fear and apprehension about everyday situations. Even with significant progress over the past few years, predicting anxiety from electroencephalographic (EEG) signals, specifically using error-related negativity (ERN), still remains challenging. Following the PRISMA protocol, this paper systematically reviews 54 research papers on using EEG and ERN markers for anxiety detection published in the last 10 years (2013 -- 2023). Our analysis highlights the wide usage of traditional machine learning, such as support vector machines and random forests, as well as deep learning models, such as convolutional neural networks and recurrent neural networks across different data types. Our analysis reveals that the development of a robust and generic anxiety prediction method still needs to address real-world challenges, such as task-specific setup, feature selection and computational modelling. We conclude this review by offering potential future direction for non-invasive, objective anxiety diagnostics, deployed across diverse populations and anxiety sub-types.

Md Rakibul Hasan, Md Zakir Hossain, Aneesh Krishna et al.

Detecting empathy from video interactions is an emerging area of research, particularly in healthcare and social robotics. However, privacy and ethical concerns often prevent the release of raw video data, with many datasets instead shared as pre-extracted tabular features. Previous work on such datasets has established classical tree-based models as the state of the art. Motivated by recent successes of large-scale foundation models for text, we investigate the potential of tabular foundation models (TFMs) for empathy detection from video-derived tabular data. Our proposed system, TFMPathy, is demonstrated with two recent TFMs (TabPFN v2 and TabICL) under both in-context learning and fine-tuning paradigms. On a public human-robot interaction benchmark, TFMPathy significantly improves empathy detection accuracy reported in the literature. While the established evaluation protocol in the literature does not ensure cross-subject generalisation, our evaluation scheme also captures such generalisation. We show that TFMPathy under a fine-tuning setup has better cross-subject generalisation capacity over baseline methods (accuracy: $0.590 \rightarrow 0.730$; AUC: $0.564 \rightarrow 0.669$). Given the ongoing privacy and ethical constraints around raw video sharing, the proposed TFMPathy system provides a practical and scalable path toward building AI systems dependent on human-centred video datasets. Our code is publicly available at https://github.com/hasan-rakibul/TFMPathy (will be made available upon acceptance of this paper).

Md Rakibul Hasan, Yue Yao, Md Zakir Hossain et al.

Large language models (LLMs) have revolutionised many fields, with LLM-as-a-service (LLMSaaS) offering accessible, general-purpose solutions without costly task-specific training. In contrast to the widely studied prompt engineering for directly solving tasks (in vivo), this paper explores LLMs' potential for in-vitro applications: using LLM-generated labels to improve supervised training of mainstream models. We examine two strategies - (1) noisy label correction and (2) training data augmentation - in empathy computing, an emerging task to predict psychology-based questionnaire outcomes from inputs like textual narratives. Crowdsourced datasets in this domain often suffer from noisy labels that misrepresent underlying empathy. We show that replacing or supplementing these crowdsourced labels with LLM-generated labels, developed using psychology-based scale-aware prompts, achieves statistically significant accuracy improvements. Notably, the RoBERTa pre-trained language model (PLM) trained with noise-reduced labels yields a state-of-the-art Pearson correlation coefficient of 0.648 on the public NewsEmp benchmarks. This paper further analyses evaluation metric selection and demographic biases to help guide the future development of more equitable empathy computing models. Code and LLM-generated labels are available at https://github.com/hasan-rakibul/LLMPathy.

Zeyu Zhang, Khandaker Asif Ahmed, Md Rakibul Hasan et al.

Diabetes, resulting from inadequate insulin production or utilization, causes extensive harm to the body. Existing diagnostic methods are often invasive and come with drawbacks, such as cost constraints. Although there are machine learning models like Classwise k Nearest Neighbor (CkNN) and General Regression Neural Network (GRNN), they struggle with imbalanced data and result in under-performance. Leveraging advancements in sensor technology and machine learning, we propose a non-invasive diabetes diagnosis using a Back Propagation Neural Network (BPNN) with batch normalization, incorporating data re-sampling and normalization for class balancing. Our method addresses existing challenges such as limited performance associated with traditional machine learning. Experimental results on three datasets show significant improvements in overall accuracy, sensitivity, and specificity compared to traditional methods. Notably, we achieve accuracies of 89.81% in Pima diabetes dataset, 75.49% in CDC BRFSS2015 dataset, and 95.28% in Mesra Diabetes dataset. This underscores the potential of deep learning models for robust diabetes diagnosis. See project website https://steve-zeyu-zhang.github.io/DiabetesDiagnosis/

Yixiao Chen, Yue Yao, Ruining Yang et al.

This article investigates the critical issue of dataset bias in medical imaging, with a particular emphasis on racial disparities caused by uneven population distribution in dataset collection. Our analysis reveals that medical segmentation datasets are significantly biased, primarily influenced by the demographic composition of their collection sites. For instance, Scanning Laser Ophthalmoscopy (SLO) fundus datasets collected in the United States predominantly feature images of White individuals, with minority racial groups underrepresented. This imbalance can result in biased model performance and inequitable clinical outcomes, particularly for minority populations. To address this challenge, we propose a novel training set search strategy aimed at reducing these biases by focusing on underrepresented racial groups. Our approach utilizes existing datasets and employs a simple greedy algorithm to identify source images that closely match the target domain distribution. By selecting training data that aligns more closely with the characteristics of minority populations, our strategy improves the accuracy of medical segmentation models on specific minorities, i.e., Black. Our experimental results demonstrate the effectiveness of this approach in mitigating bias. We also discuss the broader societal implications, highlighting how addressing these disparities can contribute to more equitable healthcare outcomes.

Md Jobayer, Md. Mehedi Hasan Shawon, Md Rakibul Hasan et al.

Objective: Heart murmurs are abnormal sounds caused by turbulent blood flow within the heart. Several diagnostic methods are available to detect heart murmurs and their severity, such as cardiac auscultation, echocardiography, phonocardiogram (PCG), etc. However, these methods have limitations, including extensive training and experience among healthcare providers, cost and accessibility of echocardiography, as well as noise interference and PCG data processing. This study aims to develop a novel end-to-end real-time heart murmur detection approach using traditional and depthwise separable convolutional networks. Methods: Continuous wavelet transform (CWT) was applied to extract meaningful features from the PCG data. The proposed network has three parts: the Squeeze net, the Bottleneck, and the Expansion net. The Squeeze net generates a compressed data representation, whereas the Bottleneck layer reduces computational complexity using a depthwise-separable convolutional network. The Expansion net is responsible for up-sampling the compressed data to a higher dimension, capturing tiny details of the representative data. Results: For evaluation, we used four publicly available datasets and achieved state-of-the-art performance in all datasets. Furthermore, we tested our proposed network on two resource-constrained devices: a Raspberry PI and an Android device, stripping it down into a tiny machine learning model (TinyML), achieving a maximum of 99.70%. Conclusion: The proposed model offers a deep learning framework for real-time accurate heart murmur detection within limited resources. Significance: It will significantly result in more accessible and practical medical services and reduced diagnosis time to assist medical professionals. The code is publicly available at TBA.

Md Rakibul Hasan, Md Zakir Hossain, Aneesh Krishna et al.

Supervised learning for empathy regression is challenged by noisy self-reported empathy scores. While many algorithms have been proposed for learning with noisy labels in textual classification problems, the regression counterpart is relatively under-explored. We propose UPLME, an uncertainty-aware probabilistic language modelling framework to capture label noise in the regression setting of empathy detection. UPLME includes a probabilistic language model that predicts both empathy score and heteroscedastic uncertainty and is trained using Bayesian concepts with variational model ensembling. We further introduce two novel loss components: one penalises degenerate Uncertainty Quantification (UQ), and another enforces the similarity between the input pairs on which we predict empathy. UPLME provides state-of-the-art performance (Pearson Correlation Coefficient: $0.558\rightarrow0.580$ and $0.629\rightarrow0.634$) in terms of the performance reported in the literature in two public benchmarks, having label noise. Through synthetic label noise injection, we show that UPLME is effective in separating noisy and clean samples based on the predicted uncertainty. UPLME further outperform (Calibration error: $0.571\rightarrow0.376$) a recent variational model ensembling-based UQ method designed for regression problems.

Junliang Ye, Lei Wang, Md Zakir Hossain

Reconstructing natural images from functional magnetic resonance imaging (fMRI) data remains a core challenge in natural decoding due to the mismatch between the richness of visual stimuli and the noisy, low resolution nature of fMRI signals. While recent two-stage models, combining deep variational autoencoders (VAEs) with diffusion models, have advanced this task, they treat all spatial-frequency components of the input equally. This uniform treatment forces the model to extract meaning features and suppress irrelevant noise simultaneously, limiting its effectiveness. We introduce FreqSelect, a lightweight, adaptive module that selectively filters spatial-frequency bands before encoding. By dynamically emphasizing frequencies that are most predictive of brain activity and suppressing those that are uninformative, FreqSelect acts as a content-aware gate between image features and natural data. It integrates seamlessly into standard very deep VAE-diffusion pipelines and requires no additional supervision. Evaluated on the Natural Scenes dataset, FreqSelect consistently improves reconstruction quality across both low- and high-level metrics. Beyond performance gains, the learned frequency-selection patterns offer interpretable insights into how different visual frequencies are represented in the brain. Our method generalizes across subjects and scenes, and holds promise for extension to other neuroimaging modalities, offering a principled approach to enhancing both decoding accuracy and neuroscientific interpretability.

Haodong Yang, Lei Wang, Md Zakir Hossain

Low-Rank Adaptation (LoRA) is a widely adopted parameter-efficient fine-tuning (PEFT) method that injects two trainable low-rank matrices (A and B) into frozen pretrained models. While efficient, LoRA constrains updates to a fixed low-rank subspace (Delta W = BA), which can limit representational capacity and hinder downstream performance. We introduce Subspace Recomposition in Low-Rank Adaptation (SRLoRA) via importance-based fusion and reinitialization, a novel approach that enhances LoRA's expressiveness without compromising its lightweight structure. SRLoRA assigns importance scores to each LoRA pair (a column of B and the corresponding row of A), and dynamically recomposes the subspace during training. Less important pairs are fused into the frozen backbone, freeing capacity to reinitialize new pairs along unused principal directions derived from the pretrained weight's singular value decomposition. This mechanism enables continual subspace refreshment and richer adaptation over time, without increasing the number of trainable parameters. We evaluate SRLoRA on both language and vision tasks, including the GLUE benchmark and various image classification datasets. SRLoRA consistently achieves faster convergence and improved accuracy over standard LoRA, demonstrating its generality, efficiency, and potential for broader PEFT applications.

Yan Yang, Md Zakir Hossain, Xuesong Li et al.

Spatial transcriptomics (ST) captures gene expression within distinct regions (i.e., windows) of a tissue slide. Traditional supervised learning frameworks applied to model ST are constrained to predicting expression from slide image windows for gene types seen during training, failing to generalize to unseen gene types. To overcome this limitation, we propose a semantic guided network (SGN), a pioneering zero-shot framework for predicting gene expression from slide image windows. Considering a gene type can be described by functionality and phenotype, we dynamically embed a gene type to a vector per its functionality and phenotype, and employ this vector to project slide image windows to gene expression in feature space, unleashing zero-shot expression prediction for unseen gene types. The gene type functionality and phenotype are queried with a carefully designed prompt from a pre-trained large language model (LLM). On standard benchmark datasets, we demonstrate competitive zero-shot performance compared to past state-of-the-art supervised learning approaches.

Ruiqi Chen, Atiqul Islam, Tom Gedeon et al.

Pupillary responses (PR) change differently for different types of stimuli. This study aims to check whether observers PR can recognise real and posed smiles from a set of smile images and videos. We showed the smile images and smile videos stimuli to observers, and recorded their pupillary responses considering four different situations, namely paired videos, paired images, single videos, and single images. When the same smiler was viewed by observers in both real and posed smile forms, we refer them as paired; otherwise we use the term single. The primary analysis on pupil data revealed that the differences of pupillary response between real and posed smiles are more significant in case of paired videos compared to others. This result is found from timeline analysis, KS-test, and ANOVA test. Overall, our model can recognise real and posed smiles from observers pupillary responses instead of smilers responses. Our research will be applicable in affective computing and computer-human interaction for measuring emotional authenticity.

Yan Yang, Md Zakir Hossain, Tom Gedeon et al.

Interactive facial image manipulation attempts to edit single and multiple face attributes using a photo-realistic face and/or semantic mask as input. In the absence of the photo-realistic image (only sketch/mask available), previous methods only retrieve the original face but ignore the potential of aiding model controllability and diversity in the translation process. This paper proposes a sketch-to-image generation framework called S2FGAN, aiming to improve users' ability to interpret and flexibility of face attribute editing from a simple sketch. The proposed framework modifies the constrained latent space semantics trained on Generative Adversarial Networks (GANs). We employ two latent spaces to control the face appearance and adjust the desired attributes of the generated face. Instead of constraining the translation process by using a reference image, the users can command the model to retouch the generated images by involving the semantic information in the generation process. In this way, our method can manipulate single or multiple face attributes by only specifying attributes to be changed. Extensive experimental results on CelebAMask-HQ dataset empirically shows our superior performance and effectiveness on this task. Our method successfully outperforms state-of-the-art methods on attribute manipulation by exploiting greater control of attribute intensity.

Yan Yang, Md Zakir Hossain, Tom Gedeon et al.

Smiles play a vital role in the understanding of social interactions within different communities, and reveal the physical state of mind of people in both real and deceptive ways. Several methods have been proposed to recognize spontaneous and posed smiles. All follow a feature-engineering based pipeline requiring costly pre-processing steps such as manual annotation of face landmarks, tracking, segmentation of smile phases, and hand-crafted features. The resulting computation is expensive, and strongly dependent on pre-processing steps. We investigate an end-to-end deep learning model to address these problems, the first end-to-end model for spontaneous and posed smile recognition. Our fully automated model is fast and learns the feature extraction processes by training a series of convolution and ConvLSTM layer from scratch. Our experiments on four datasets demonstrate the robustness and generalization of the proposed model by achieving state-of-the-art performances.