LLMs Can Simulate Standardized Patients via Agent CoevolutionZhuoyun Du, Lujie Zheng, Renjun Hu et al.
Training medical personnel using standardized patients (SPs) remains a complex challenge, requiring extensive domain expertise and role-specific practice. Previous research on Large Language Model (LLM)-based SPs mostly focuses on improving data retrieval accuracy or adjusting prompts through human feedback. However, this focus has overlooked the critical need for patient agents to learn a standardized presentation pattern that transforms data into human-like patient responses through unsupervised simulations. To address this gap, we propose EvoPatient, a novel simulated patient framework in which a patient agent and doctor agents simulate the diagnostic process through multi-turn dialogues, simultaneously gathering experience to improve the quality of both questions and answers, ultimately enabling human doctor training. Extensive experiments on various cases demonstrate that, by providing only overall SP requirements, our framework improves over existing reasoning methods by more than 10\% in requirement alignment and better human preference, while achieving an optimal balance of resource consumption after evolving over 200 cases for 10 hours, with excellent generalizability. Our system will be available at https://github.com/ZJUMAI/EvoPatient.
MPU: Towards Secure and Privacy-Preserving Knowledge Unlearning for Large Language ModelsTiantong Wang, Xinyu Yan, Tiantong Wu et al.
Machine unlearning for large language models often faces a privacy dilemma in which strict constraints prohibit sharing either the server's parameters or the client's forget set. To address this dual non-disclosure constraint, we propose MPU, an algorithm-agnostic privacy-preserving Multiple Perturbed Copies Unlearning framework that primarily introduces two server-side modules: Pre-Process for randomized copy generation and Post-Process for update aggregation. In Pre-Process, the server distributes multiple perturbed and reparameterized model instances, allowing the client to execute unlearning locally on its private forget set without accessing the server's exact original parameters. After local unlearning, the server performs Post-Process by inverting the reparameterization and aggregating updates with a harmonic denoising procedure to alleviate the impact of perturbation. Experiments with seven unlearning algorithms show that MPU achieves comparable unlearning performance to noise-free baselines, with most algorithms' average degradation well below 1% under 10% noise, and can even outperform the noise-free baseline for some algorithms under 1% noise. Code is available at https://github.com/Tristan-SHU/MPU.
AutoMLGen: Navigating Fine-Grained Optimization for Coding AgentsShangheng Du, Xiangchao Yan, Dengyang Jiang et al.
Large language models (LLMs) have shown impressive performance in general programming tasks. However, in Machine Learning Engineering (MLE) scenarios such as AutoML and Kaggle competitions, achieving high performance depends heavily on expert intervention and repeated adjustments rather than simply generating correct code. When applied directly to these tasks, LLMs often lack fine-grained domain priors, and existing MLE approaches that use linear or tree-structured searches limit knowledge transfer to adjacent hierarchical links. As a result, they cannot leverage past full trajectories or share information across branches, limiting self-evolving ability and search space diversity. To address these limitations, we introduce AutoMLGen, an LLM-based coding agent that integrates a domain knowledge base for high-quality prior guidance and Monte Carlo Graph Search (MCGS) for efficient exploration. MCGS retains the tree-guided exploration of MCTS while embedding a graph structure into the expansion stage to enable dynamic path reorganization, historical trajectory reuse, and multi-solution fusion to support both self-evolution and collaborative learning. Combined with fine-grained operator sets, this design improves stability and accelerates convergence. Evaluation on the MLE-Bench shows that AutoMLGen achieves state-of-the-art performance in numerous dimensions, such as the average medal rate and the valid submission rate, under a 12-hour budget (half the standard runtime). The code is available at https://github.com/Alpha-Innovator/InternAgent.
FedBKD: Distilled Federated Learning to Embrace Gerneralization and Personalization on Non-IID DataYushan Zhao, Jinyuan He, Donglai Chen et al.
Federated learning (FL) is a decentralized collaborative machine learning (ML) technique. It provides a solution to the issues of isolated data islands and data privacy leakage in industrial ML practices. One major challenge in FL is handling the non-identical and independent distributed (non-IID) data. Current solutions either focus on constructing an all-powerful global model, or customizing personalized local models. Few of them can provide both a well-generalized global model and well-performed local models at the same time. Additionally, many FL solutions to the non-IID problem are benefited from introducing public datasets. However, this will also increase the risk of data leakage. To tackle the problems, we propose a novel data-free distillation framework, Federated Bidirectional Knowledge Distillation (FedBKD). Specifically, we train Generative Adversarial Networks (GAN) for synthetic data. During the GAN training, local models serve as discriminators and their parameters are frozen. The synthetic data is then used for bidirectional distillation between global and local models to achieve knowledge interactions so that performances for both sides are improved. We conduct extensive experiments on 4 benchmarks under different non-IID settings. The results show that FedBKD achieves SOTA performances in every case.