Ting Jin

Ting Jin, Xingran Xie, Renjie Wan et al.

Histology analysis of the tumor micro-environment integrated with genomic assays is the gold standard for most cancers in modern medicine. This paper proposes a Gene-induced Multimodal Pre-training (GiMP) framework, which jointly incorporates genomics and Whole Slide Images (WSIs) for classification tasks. Our work aims at dealing with the main challenges of multi-modality image-omic classification w.r.t. (1) the patient-level feature extraction difficulties from gigapixel WSIs and tens of thousands of genes, and (2) effective fusion considering high-order relevance modeling. Concretely, we first propose a group multi-head self-attention gene encoder to capture global structured features in gene expression cohorts. We design a masked patch modeling paradigm (MPM) to capture the latent pathological characteristics of different tissues. The mask strategy is randomly masking a fixed-length contiguous subsequence of patch embeddings of a WSI. Finally, we combine the classification tokens of paired modalities and propose a triplet learning module to learn high-order relevance and discriminative patient-level information.After pre-training, a simple fine-tuning can be adopted to obtain the classification results. Experimental results on the TCGA dataset show the superiority of our network architectures and our pre-training framework, achieving 99.47% in accuracy for image-omic classification. The code is publicly available at https://github.com/huangwudiduan/GIMP.

Ling Zhang, Boxiang Yun, Ting Jin et al.

Prediction of genetic biomarkers, e.g., microsatellite instability in colorectal cancer is crucial for clinical decision making. But, two primary challenges hamper accurate prediction: (1) It is difficult to construct a pathology-aware representation involving the complex interconnections among pathological components. (2) WSIs contain a large proportion of areas unrelated to genetic biomarkers, which make the model easily overfit simple but irrelative instances. We hereby propose a Dictionary-based hierarchical pathology mining with hard-instance-assisted classifier Debiasing framework to address these challenges, dubbed as D2Bio. Our first module, dictionary-based hierarchical pathology mining, is able to mine diverse and very fine-grained pathological contextual interaction without the limit to the distances between patches. The second module, hard-instance-assisted classfier debiasing, learns a debiased classifier via focusing on hard but task-related features, without any additional annotations. Experimental results on five cohorts show the superiority of our method, with over 4% improvement in AUROC compared with the second best on the TCGA-CRC-MSI cohort. Our analysis further shows the clinical interpretability of D2Bio in genetic biomarker diagnosis and potential clinical utility in survival analysis. Code will be available at https://github.com/DeepMed-Lab-ECNU/D2Bio.

Lu Wang, Tianyuan Zhang, Yikai Han et al.

With recent breakthroughs in deep neural networks, numerous tasks within autonomous driving have exhibited remarkable performance. However, deep learning models are susceptible to adversarial attacks, presenting significant security risks to autonomous driving systems. Presently, end-to-end architectures have emerged as the predominant solution for autonomous driving, owing to their collaborative nature across different tasks. Yet, the implications of adversarial attacks on such models remain relatively unexplored. In this paper, we conduct comprehensive adversarial security research on the modular end-to-end autonomous driving model for the first time. We thoroughly consider the potential vulnerabilities in the model inference process and design a universal attack scheme through module-wise noise injection. We conduct large-scale experiments on the full-stack autonomous driving model and demonstrate that our attack method outperforms previous attack methods. We trust that our research will offer fresh insights into ensuring the safety and reliability of autonomous driving systems.

Jiayu Lin, Guanrong Chen, Bojun Jin et al.

In this paper we present the results of the AI-Debater 2023 Challenge held by the Chinese Conference on Affect Computing (CCAC 2023), and introduce the related datasets. We organize two tracks to handle the argumentative generation tasks in different scenarios, namely, Counter-Argument Generation (Track 1) and Claim-based Argument Generation (Track 2). Each track is equipped with its distinct dataset and baseline model respectively. In total, 32 competing teams register for the challenge, from which we received 11 successful submissions. In this paper, we will present the results of the challenge and a summary of the systems, highlighting commonalities and innovations among participating systems. Datasets and baseline models of the AI-Debater 2023 Challenge have been already released and can be accessed through the official website of the challenge.

Tianyuan Zhang, Ting Jin, Lu Wang et al.

Vision-Language Models (VLMs) have recently emerged as a promising paradigm in autonomous driving (AD). However, current performance evaluation protocols for VLM-based AD systems (ADVLMs) are predominantly confined to open-loop settings with static inputs, neglecting the more realistic and informative closed-loop setting that captures interactive behavior, feedback resilience, and real-world safety. To address this, we introduce Bench2ADVLM, a unified hierarchical closed-loop evaluation framework for real-time, interactive assessment of ADVLMs across both simulation and physical platforms. Inspired by dual-process theories of cognition, we first adapt diverse ADVLMs to simulation environments via a dual-system adaptation architecture. In this design, heterogeneous high-level driving commands generated by target ADVLMs (fast system) are interpreted by a general-purpose VLM (slow system) into standardized mid-level control actions suitable for execution in simulation. To bridge the gap between simulation and reality, we design a physical control abstraction layer that translates these mid-level actions into low-level actuation signals, enabling, for the first time, closed-loop testing of ADVLMs on physical vehicles. To enable more comprehensive evaluation, Bench2ADVLM introduces a self-reflective scenario generation module that automatically explores model behavior and uncovers potential failure modes for safety-critical scenario generation. Overall, Bench2ADVLM establishes a hierarchical evaluation pipeline that seamlessly integrates high-level abstract reasoning, mid-level simulation actions, and low-level real-world execution. Experiments on diverse scenarios across multiple state-of-the-art ADVLMs and physical platforms validate the diagnostic strength of our framework, revealing that existing ADVLMs still exhibit limited performance under closed-loop conditions.