Bruno Sanguinetti

Luis Oala, Marco Aversa, Gabriel Nobis et al.

Camera images are ubiquitous in machine learning research. They also play a central role in the delivery of important services spanning medicine and environmental surveying. However, the application of machine learning models in these domains has been limited because of robustness concerns. A primary failure mode are performance drops due to differences between the training and deployment data. While there are methods to prospectively validate the robustness of machine learning models to such dataset drifts, existing approaches do not account for explicit models of the primary object of interest: the data. This limits our ability to study and understand the relationship between data generation and downstream machine learning model performance in a physically accurate manner. In this study, we demonstrate how to overcome this limitation by pairing traditional machine learning with physical optics to obtain explicit and differentiable data models. We demonstrate how such data models can be constructed for image data and used to control downstream machine learning model performance related to dataset drift. The findings are distilled into three applications. First, drift synthesis enables the controlled generation of physically faithful drift test cases to power model selection and targeted generalization. Second, the gradient connection between machine learning task model and data model allows advanced, precise tolerancing of task model sensitivity to changes in the data generation. These drift forensics can be used to precisely specify the acceptable data environments in which a task model may be run. Third, drift optimization opens up the possibility to create drifts that can help the task model learn better faster, effectively optimizing the data generating process itself. A guide to access the open code and datasets is available at https://github.com/aiaudit-org/raw2logit.

Marco Aversa, Gabriel Nobis, Miriam Hägele et al.

We present DiffInfinite, a hierarchical diffusion model that generates arbitrarily large histological images while preserving long-range correlation structural information. Our approach first generates synthetic segmentation masks, subsequently used as conditions for the high-fidelity generative diffusion process. The proposed sampling method can be scaled up to any desired image size while only requiring small patches for fast training. Moreover, it can be parallelized more efficiently than previous large-content generation methods while avoiding tiling artifacts. The training leverages classifier-free guidance to augment a small, sparsely annotated dataset with unlabelled data. Our method alleviates unique challenges in histopathological imaging practice: large-scale information, costly manual annotation, and protective data handling. The biological plausibility of DiffInfinite data is evaluated in a survey by ten experienced pathologists as well as a downstream classification and segmentation task. Samples from the model score strongly on anti-copying metrics which is relevant for the protection of patient data.

Valeria Pais, Malena Mendilaharzu, Daniele Faccio et al.

Real-world deployment of AI vision models is both fueled and limited by the data available for training and testing. Real datasets are sparse and uneven: long-tailed or unbalanced distributions hinder generalization, and the low number of samples in low density regions makes it hard to run evaluations. Synthetic data can fill these gaps, providing us with a way to sample the input space more continuously and improve data coverage for benchmarks. Focusing on the autonomous driving safety-critical case of pedestrian detection in the dark, we show how synthetic low-light samples can be used to better characterize the performance of a state-of-the-art object detection model as a function of the scene illumination. We use a synthetic RAW image augmentation technique to generate low-light samples that match the noise model of the camera sensor. Performance metrics on real and synthetic low-light data are similar, indicating that the AI model finds it hard to distinguish between them.

Enrico Pomarico, Cédric Schmidt, Florian Chays et al.

The impressive growth of data throughput in optical microscopy has triggered a widespread use of supervised learning (SL) models running on compressed image datasets for efficient automated analysis. However, since lossy image compression risks to produce unpredictable artifacts, quantifying the effect of data compression on SL applications is of pivotal importance to assess their reliability, especially for clinical use. We propose an experimental method to evaluate the tolerability of image compression distortions in 2D and 3D cell segmentation SL tasks: predictions on compressed data are compared to the raw predictive uncertainty, which is numerically estimated from the raw noise statistics measured through sensor calibration. We show that predictions on object- and image-specific segmentation parameters can be altered by up to 15% and more than 10 standard deviations after 16-to-8 bits downsampling or JPEG compression. In contrast, a recently developed lossless compression algorithm provides a prediction spread which is statistically equivalent to that stemming from raw noise, while providing a compression ratio of up to 10:1. By setting a lower bound to the SL predictive uncertainty, our technique can be generalized to validate a variety of data analysis pipelines in SL-assisted fields.

Bruno Sanguinetti, Anthony Martin, Giulia Traverso et al.

We show that the quantum nature of light can be used to hide a secret message within a photograph. Using this physical principle we achieve information-theoretic secure steganography, which had remained elusive until now. The protocol is such that the digital picture in which the secret message is embedded is perfectly undistinguishable from an ordinary photograph. This implies that, on a fundamental level, it is impossible to discriminate a private communication from an exchange of photographs.