Guoshuai Wang

Zhengyong Huang, Sijuan Zou, Guoshuai Wang et al.

Achieving accurate and automated tumor segmentation plays an important role in both clinical practice and radiomics research. Segmentation in medicine is now often performed manually by experts, which is a laborious, expensive and error-prone task. Manual annotation relies heavily on the experience and knowledge of these experts. In addition, there is much intra- and interobserver variation. Therefore, it is of great significance to develop a method that can automatically segment tumor target regions. In this paper, we propose a deep learning segmentation method based on multimodal positron emission tomography-computed tomography (PET-CT), which combines the high sensitivity of PET and the precise anatomical information of CT. We design an improved spatial attention network(ISA-Net) to increase the accuracy of PET or CT in detecting tumors, which uses multi-scale convolution operation to extract feature information and can highlight the tumor region location information and suppress the non-tumor region location information. In addition, our network uses dual-channel inputs in the coding stage and fuses them in the decoding stage, which can take advantage of the differences and complementarities between PET and CT. We validated the proposed ISA-Net method on two clinical datasets, a soft tissue sarcoma(STS) and a head and neck tumor(HECKTOR) dataset, and compared with other attention methods for tumor segmentation. The DSC score of 0.8378 on STS dataset and 0.8076 on HECKTOR dataset show that ISA-Net method achieves better segmentation performance and has better generalization. Conclusions: The method proposed in this paper is based on multi-modal medical image tumor segmentation, which can effectively utilize the difference and complementarity of different modes. The method can also be applied to other multi-modal data or single-modal data by proper adjustment.

Yunyi Xuan, Hao Yi, Fengling Mao et al.

Personalized user understanding from large-scale digital traces remains a fundamental challenge. Traditional user profiling methods rely on discriminative models and manual feature engineering to predict discrete attributes, often producing fragmented and logically inconsistent profiles that generalize poorly to long-tail behaviors. In this work, we study a generative paradigm in which large language models (LLMs) summarize long and noisy behavioral histories into coherent narratives that capture nuanced user evolution. Our experiments show that even strong LLMs remain limited in complex and implicit personalization reasoning. We propose UserGPT, a framework for improving LLM-based persona understanding through both attribute generation and summary generation. To address the scarcity of real-world behavioral data, we develop a User Behavior Simulation Engine that produces realistic and complex user trajectories. We further introduce a Data-Centric Semantization module that transforms heterogeneous behavioral logs into structured and semantically coherent inputs, reducing noise and sparsity. On top of this pipeline, we design a curriculum-driven post-training strategy that combines multi-stage Supervised Fine-Tuning (SFT) with Dual-Filter Group Relative Policy Optimization (DF-GRPO) to strengthen reasoning over long behavioral histories. We also construct HPR-Bench, a benchmark for holistic persona reasoning derived from simulated data. On HPR-Bench, UserGPT achieves an Avg@10 score of 0.7325 on tag prediction and an $Acc_{Ex}$ score of 0.7528 on summary generation, while compressing behavioral records by up to 97.9% with critical information preserved. These results demonstrate the effectiveness of UserGPT for holistic persona reasoning and personalized user-agent interaction.