Ottavio de Cobelli

Jorge F. Lazo, Benoit Rosa, Michele Catellani et al.

Objective: Accurate visual classification of bladder tissue during Trans-Urethral Resection of Bladder Tumor (TURBT) procedures is essential to improve early cancer diagnosis and treatment. During TURBT interventions, White Light Imaging (WLI) and Narrow Band Imaging (NBI) techniques are used for lesion detection. Each imaging technique provides diverse visual information that allows clinicians to identify and classify cancerous lesions. Computer vision methods that use both imaging techniques could improve endoscopic diagnosis. We address the challenge of tissue classification when annotations are available only in one domain, in our case WLI, and the endoscopic images correspond to an unpaired dataset, i.e. there is no exact equivalent for every image in both NBI and WLI domains. Method: We propose a semi-surprised Generative Adversarial Network (GAN)-based method composed of three main components: a teacher network trained on the labeled WLI data; a cycle-consistency GAN to perform unpaired image-to-image translation, and a multi-input student network. To ensure the quality of the synthetic images generated by the proposed GAN we perform a detailed quantitative, and qualitative analysis with the help of specialists. Conclusion: The overall average classification accuracy, precision, and recall obtained with the proposed method for tissue classification are 0.90, 0.88, and 0.89 respectively, while the same metrics obtained in the unlabeled domain (NBI) are 0.92, 0.64, and 0.94 respectively. The quality of the generated images is reliable enough to deceive specialists. Significance: This study shows the potential of using semi-supervised GAN-based bladder tissue classification when annotations are limited in multi-domain data. The dataset is available at https://zenodo.org/record/7741476#.ZBQUK7TMJ6k

Jorge F. Lazo, Sara Moccia, Aldo Marzullo et al.

Ureteroscopy and cystoscopy are the gold standard methods to identify and treat tumors along the urinary tract. It has been reported that during a normal procedure a rate of 10-20 % of the lesions could be missed. In this work we study the implementation of 3 different Convolutional Neural Networks (CNNs), using a 2-steps training strategy, to classify images from the urinary tract with and without lesions. A total of 6,101 images from ureteroscopy and cystoscopy procedures were collected. The CNNs were trained and tested using transfer learning in a two-steps fashion on 3 datasets. The datasets used were: 1) only ureteroscopy images, 2) only cystoscopy images and 3) the combination of both of them. For cystoscopy data, VGG performed better obtaining an Area Under the ROC Curve (AUC) value of 0.846. In the cases of ureteroscopy and the combination of both datasets, ResNet50 achieved the best results with AUC values of 0.987 and 0.940. The use of a training dataset that comprehends both domains results in general better performances, but performing a second stage of transfer learning achieves comparable ones. There is no single model which performs better in all scenarios, but ResNet50 is the network that achieves the best performances in most of them. The obtained results open the opportunity for further investigation with a view for improving lesion detection in endoscopic images of the urinary system.