Frank H. P. Fitzek

Jorge Torres Gómez, Pit Hofmann, Lisa Y. Debus et al.

Recent developments in the Internet of Bio-Nano-Things (IoBNT) are laying the foundation for innovative healthcare applications that envision a network of remotely coordinated nanodevices within the human body to monitor and actuate over potential diseases. However, interconnecting such nanodevices requires communication strategies that can cope with molecular communication (MC) channels, whose complex, stochastic, and dynamic behavior often makes accurate physical modeling infeasible. To explore the limits of nanodevice interconnectivity under these conditions, this survey focuses on data-driven communication strategies for MC systems, with particular emphasis on machine learning (ML) methods and neural network (NN) architectures for a robust and adaptive communication scheme at the nanoscale. Research on NN-enabled MC spans several aspects covered in this survey, including NNs for communication in IoBNT networks, the feasibility of biocompatible NN realization, explainable approaches, and the generation of training datasets. We also include open-source code examples to support reproducible research across key MC scenarios. Finally, we identify emerging challenges, including the need for robust NN architectures, biologically integrated NN modules, and scalable training strategies.

Rodrigo Hernangómez, Philipp Geuer, Alexandros Palaios et al.

The evolution of wireless communications into 6G and beyond is expected to rely on new machine learning (ML)-based capabilities. These can enable proactive decisions and actions from wireless-network components to sustain quality-of-service (QoS) and user experience. Moreover, new use cases in the area of vehicular and industrial communications will emerge. Specifically in the area of vehicle communication, vehicle-to-everything (V2X) schemes will benefit strongly from such advances. With this in mind, we have conducted a detailed measurement campaign that paves the way to a plethora of diverse ML-based studies. The resulting datasets offer GPS-located wireless measurements across diverse urban environments for both cellular (with two different operators) and sidelink radio access technologies, thus enabling a variety of different studies towards V2X. The datasets are labeled and sampled with a high time resolution. Furthermore, we make the data publicly available with all the necessary information to support the onboarding of new researchers. We provide an initial analysis of the data showing some of the challenges that ML needs to overcome and the features that ML can leverage, as well as some hints at potential research studies.

Alexandros Palaios, Christian L. Vielhaus, Daniel F. Külzer et al.

As cellular networks evolve towards the 6th generation, machine learning is seen as a key enabling technology to improve the capabilities of the network. Machine learning provides a methodology for predictive systems, which can make networks become proactive. This proactive behavior of the network can be leveraged to sustain, for example, a specific quality of service requirement. With predictive quality of service, a wide variety of new use cases, both safety- and entertainment-related, are emerging, especially in the automotive sector. Therefore, in this work, we consider maximum throughput prediction enhancing, for example, streaming or high-definition mapping applications. We discuss the entire machine learning workflow highlighting less regarded aspects such as the detailed sampling procedures, the in-depth analysis of the dataset characteristics, the effects of splits in the provided results, and the data availability. Reliable machine learning models need to face a lot of challenges during their lifecycle. We highlight how confidence can be built on machine learning technologies by better understanding the underlying characteristics of the collected data. We discuss feature engineering and the effects of different splits for the training processes, showcasing that random splits might overestimate performance by more than twofold. Moreover, we investigate diverse sets of input features, where network information proved to be most effective, cutting the error by half. Part of our contribution is the validation of multiple machine learning models within diverse scenarios. We also use explainable AI to show that machine learning can learn underlying principles of wireless networks without being explicitly programmed. Our data is collected from a deployed network that was under full control of the measurement team and covered different vehicular scenarios and radio environments.

Johannes V. S. Busch, Robert Voelckner, Peter Sossalla et al.

Traffic congestion in dense urban centers presents an economical and environmental burden. In recent years, the availability of vehicle-to-anything communication allows for the transmission of detailed vehicle states to the infrastructure that can be used for intelligent traffic light control. The other way around, the infrastructure can provide vehicles with advice on driving behavior, such as appropriate velocities, which can improve the efficacy of the traffic system. Several research works applied deep reinforcement learning to either traffic light control or vehicle speed advice. In this work, we propose a first attempt to jointly learn the control of both. We show this to improve the efficacy of traffic systems. In our experiments, the joint control approach reduces average vehicle trip delays, w.r.t. controlling only traffic lights, in eight out of eleven benchmark scenarios. Analyzing the qualitative behavior of the vehicle speed advice policy, we observe that this is achieved by smoothing out the velocity profile of vehicles nearby a traffic light. Learning joint control of traffic signaling and speed advice in the real world could help to reduce congestion and mitigate the economical and environmental repercussions of today's traffic systems.

Hosein K. Nazari, Stefan Senk, Peyman Pahlevani et al.

Network Coding (NC) is a compelling solution for increasing network efficiency. However, it discards corrupted packets and cannot achieve optimal performance in noisy communications. Since most of the information in corrupted packets is error-free, discarding them is not the best strategy. Several packet recovery techniques such as PRAC and S-PRAC were proposed to exploit corrupted packets. Yet, they are slow and only practical when the packet size is small and communication channels are not very noisy. We propose a packet recovery scheme called Fly-PRAC to address these issues. Fly-PRAC exploits algebraic relations between a group of coded packets to estimate their corrupted parts and recovers them. Unlike previous schemes, Fly-PRAC can recover coded packets at the intermediate node without decoding them. We have compared Fly-PRAC against S-PRAC. Results show when the bit error rate (ε) is 10^-4, Fly-PRAC outperforms S-PRAC by two folds for a payload of 900B. In two-hop communication with ε = 10^-4 and a payload size of 500B, by enabling the recovery in the intermediate node, Fly-PRAC reduces transmissions by 16%. In a Sparse Network Coding (SNC) scenario, with two non-zero elements in the coefficient vectors and a payload of 800B, there is a reduction by 31% on average for decoding delay.

Ruifeng Zheng, Zhihan Xu, Veronika Volkova et al.

In this paper, we study DNA-based molecular communication with microarray-style reception under reversible hybridization, where the bound-state observation exhibits both inter-symbol interference and colored counting noise. To capture these effects in a communication-oriented form, we develop a Markov state-space framework based on a voxelized reaction--diffusion model, in which a block-structured transition matrix describes molecular transport and binding/unbinding dynamics. For the microarray specialization, this representation yields the channel impulse response, the equilibrium gain, and a settling-time-based characterization of the effective channel memory. Building on the resulting symbol-rate observation model for on--off keying, we derive a grouped-binomial counting model and obtain a closed-form expression for the covariance of the counting noise. Based on these statistics, we further develop a differential-threshold detector and a finite-memory decision-feedback equalizer. Numerical results validate the theoretical correlation behavior and show that the relative performance of the proposed receivers depends strongly on the channel-memory regime.

Juan A. Cabrera, Pit Hofmann, Jonas Schulz et al.

The Shared Prosperity Internet (SPI) is a network-computing architecture that makes the benefits of automation and Artificial Intelligence (AI) broadly accessible to the society. To ground its design, this paper maps the physical constraints of Shannon, Landauer, Turing, and Einstein to three design principles: trustworthiness, sustainability, and technological sovereignty, and maps them into three technical pillars: i) post-Shannon, goal-oriented communication that transmits only what the task requires; ii) anticipatory decision-making ("negative latency") with confidence-bounded pre-action and correction; and iii) beyond-digital computing that selects energy-optimal substrates under deadline and computability constraints. The SPI is grounded in three societal use cases: remote teaching for pupils, remote teaching of robots and cyber-physical systems, and elder care. Furthermore, this paper defines measurable outcomes for an SPI, including latency decomposition, bits per event, energy and CO2 per task, safety and privacy indicators, and robustness.

Shangqing Wang, Abhirup Sain, Christopher Lehmann et al.

This paper presents the real-world implementation and field validation of a user-aware bidirectional electric vehicle (EV) charging system developed within the Mobilities for EU and DymoBat projects in Dresden. Building on earlier simulation frameworks, the system enables transition from conceptual models to operational deployment in urban environments. To support grid flexibility and sustainable mobility, the solution combines real-time vehicle and user data with a centralized optimization platform to enable dynamic charging and discharging decisions. The architecture integrates a wireless On-Board Diagnostic II (OBD-II) interface and an open middleware node connected via a 5G campus network, allowing early access to vehicle state-of-charge before plug-in. A tablet-based interface captures user preferences such as departure time and energy demand, which are incorporated into the optimization together with grid conditions. A key contribution is a multi-level communication architecture linking the EV, charging station, user interface, and grid control center using the Open Charge Point Protocol (OCPP). The system integrates software, embedded hardware, and network communication for real-time charging management. Field deployment at Ostra Sport Park in Dresden demonstrates feasibility, improved load balancing, and robust vehicle-to-grid operation. The results show that early data acquisition and predictive control can enhance system efficiency. This work provides a practical benchmark for positive energy districts and future urban e-mobility systems.

Ruifeng Zheng, Pengjie Zhou, Martín Schottlender et al.

This paper develops a molecular integrated sensing and communication (ISAC) framework that exploits the same molecular observations for physical-parameter sensing and data detection. As a representative instantiation, we consider a microfluidic molecular communication (MC) channel and study transmitter--receiver (TX--RX) distance sensing, where the distance affects the propagation delay, transient response, and inter-symbol interference structure. A distance-parameterized Markov state--space model is established to obtain distance-dependent channel impulse responses and a block observation model for on-off keying signaling. Based on this model, we design a pilot-assisted low-complexity receiver that combines distance initialization, decision-feedback equalization (DFE), and iterative joint refinement. Numerical results show accurate distance sensing and improved bit error ratio (BER), demonstrating the mutual benefit between sensing and communication and highlighting microfluidic MC as a representative platform for molecular ISAC.

Martin Schottlender, Pengjie Zhou, Veronika Volkova et al.

Concurrent advances across fields such as organoid technology, Microelectrode Arrays (MEAs), neuromorphic computing, and machine learning have given rise to a groundbreaking research paradigm: Synthetic Biological Intelligence (SBI). SBI refers to engineered systems in which living Biological Neural Networks (BNNs) are interfaced with hardware and software to perform task-oriented information processing in a closed loop. This cutting-edge technology, while still in its infancy, has the potential to deliver highly efficient performance across both computing capabilities and energy consumption. The early stage of this field underscores the need for reliable multi-scale and cross-domain interaction interfaces to support applications in robotics, biomedicine, signal processing, and neuroscience research. The hitherto lack of commercially available SBI platforms has slowed the development, as the conditions to produce a testbed are expensive and cumbersome. The introduction of standardized, platform- and cloud-integrated BNNs has been a crucial catalyst for the scientific community, improving the accessibility of SBI and leading the way to further developments. In this survey, we summarize the innovations that contributed to the emergence of SBI and the first testbed interfaces that enabled its embodiment. This work reframes SBI as a bio-digital interaction system and introduces a unified protocol across encoding, decoding, system engineering, and benchmarking.