Xiang Zou

Zhangde Song, Jieyu Lu, Yuanqi Du et al.

Large language models (LLMs) are increasingly applied to scientific research, yet prevailing science benchmarks probe decontextualized knowledge and overlook the iterative reasoning, hypothesis generation, and observation interpretation that drive scientific discovery. We introduce a scenario-grounded benchmark that evaluates LLMs across biology, chemistry, materials, and physics, where domain experts define research projects of genuine interest and decompose them into modular research scenarios from which vetted questions are sampled. The framework assesses models at two levels: (i) question-level accuracy on scenario-tied items and (ii) project-level performance, where models must propose testable hypotheses, design simulations or experiments, and interpret results. Applying this two-phase scientific discovery evaluation (SDE) framework to state-of-the-art LLMs reveals a consistent performance gap relative to general science benchmarks, diminishing return of scaling up model sizes and reasoning, and systematic weaknesses shared across top-tier models from different providers. Large performance variation in research scenarios leads to changing choices of the best performing model on scientific discovery projects evaluated, suggesting all current LLMs are distant to general scientific "superintelligence". Nevertheless, LLMs already demonstrate promise in a great variety of scientific discovery projects, including cases where constituent scenario scores are low, highlighting the role of guided exploration and serendipity in discovery. This SDE framework offers a reproducible benchmark for discovery-relevant evaluation of LLMs and charts practical paths to advance their development toward scientific discovery.

Junqi Gao, Xiang Zou, YIng Ai et al.

Graph Retrieval Augmented Generation (GraphRAG) effectively enhances external knowledge integration capabilities by explicitly modeling knowledge relationships, thereby improving the factual accuracy and generation quality of Large Language Models (LLMs) in specialized domains. However, existing methods suffer from two inherent limitations: 1) Inefficient Information Aggregation: They rely on a single agent and fixed iterative patterns, making it difficult to adaptively capture multi-level textual, structural, and degree information within graph data. 2) Rigid Reasoning Mechanism: They employ preset reasoning schemes, which cannot dynamically adjust reasoning depth nor achieve precise semantic correction. To overcome these limitations, we propose Graph Counselor, an GraphRAG method based on multi-agent collaboration. This method uses the Adaptive Graph Information Extraction Module (AGIEM), where Planning, Thought, and Execution Agents work together to precisely model complex graph structures and dynamically adjust information extraction strategies, addressing the challenges of multi-level dependency modeling and adaptive reasoning depth. Additionally, the Self-Reflection with Multiple Perspectives (SR) module improves the accuracy and semantic consistency of reasoning results through self-reflection and backward reasoning mechanisms. Experiments demonstrate that Graph Counselor outperforms existing methods in multiple graph reasoning tasks, exhibiting higher reasoning accuracy and generalization ability. Our code is available at https://github.com/gjq100/Graph-Counselor.git.

Tan Pan, Shuhao Mei, Yixuan Sun et al.

Self-supervised pre-training methods in medical imaging typically treat each individual as an isolated instance, learning representations through augmentation-based objectives or masked reconstruction. They often do not adequately capitalize on a key characteristic of physiological features: anatomical structures maintain consistent spatial relationships across individuals (instances), such as the thalamus being medial to the basal ganglia, regardless of variations in brain size, shape, or pathology. We propose leveraging this cross-instance topological consistency as a supervisory signal. The challenge arises from the inherent variability in medical imaging, which can differ significantly across instances and modalities. To tackle this, we focus on two alignment regimes. (i) Intra-instance: with pixel-level correspondences available, a cross-modal triplet objective explicitly preserves local neighborhood topology. (ii) Inter-instance: without such supervision, we derive pseudo-correspondences to control partial neighborhood alignment and prevent topology collapse across modalities. We validate our approach across 7 downstream multi-modal tasks, achieving average improvements of 1.1% and 5.94% in segmentation and classification tasks, respectively, and demonstrating significantly better robustness when modalities are missing at test time.

Dong Li, Yichen Niu, Ying Ai et al.

Large language models (LLMs) have demonstrated strong performance in natural language generation but remain limited in knowle- dge-intensive tasks due to outdated or incomplete internal knowledge. Retrieval-Augmented Generation (RAG) addresses this by incorporating external retrieval, with GraphRAG further enhancing performance through structured knowledge graphs and multi-hop reasoning. However, existing GraphRAG methods largely ignore the temporal dynamics of knowledge, leading to issues such as temporal ambiguity, time-insensitive retrieval, and semantic redundancy. To overcome these limitations, we propose Temporal GraphRAG (T-GRAG), a dynamic, temporally-aware RAG framework that models the evolution of knowledge over time. T-GRAG consists of five key components: (1) a Temporal Knowledge Graph Generator that creates time-stamped, evolving graph structures; (2) a Temporal Query Decomposition mechanism that breaks complex temporal queries into manageable sub-queries; (3) a Three-layer Interactive Retriever that progressively filters and refines retrieval across temporal subgraphs; (4) a Source Text Extractor to mitigate noise; and (5) a LLM-based Generator that synthesizes contextually and temporally accurate responses. We also introduce Time-LongQA, a novel benchmark dataset based on real-world corporate annual reports, designed to test temporal reasoning across evolving knowledge. Extensive experiments show that T-GRAG significantly outperforms prior RAG and GraphRAG baselines in both retrieval accuracy and response relevance under temporal constraints, highlighting the necessity of modeling knowledge evolution for robust long-text question answering. Our code is publicly available on the T-GRAG

Mohammad Behnia, Prateek Sahu, Riccardo Paccagnella et al.

Recent security vulnerabilities that target speculative execution (e.g., Spectre) present a significant challenge for processor design. The highly publicized vulnerability uses speculative execution to learn victim secrets by changing cache state. As a result, recent computer architecture research has focused on invisible speculation mechanisms that attempt to block changes in cache state due to speculative execution. Prior work has shown significant success in preventing Spectre and other vulnerabilities at modest performance costs. In this paper, we introduce speculative interference attacks, which show that prior invisible speculation mechanisms do not fully block these speculation-based attacks. We make two key observations. First, misspeculated younger instructions can change the timing of older, bound-to-retire instructions, including memory operations. Second, changing the timing of a memory operation can change the order of that memory operation relative to other memory operations, resulting in persistent changes to the cache state. Using these observations, we demonstrate (among other attack variants) that secret information accessed by mis-speculated instructions can change the order of bound-to-retire loads. Load timing changes can therefore leave secret-dependent changes in the cache, even in the presence of invisible speculation mechanisms. We show that this problem is not easy to fix: Speculative interference converts timing changes to persistent cache-state changes, and timing is typically ignored by many cache-based defenses. We develop a framework to understand the attack and demonstrate concrete proof-of-concept attacks against invisible speculation mechanisms. We provide security definitions sufficient to block speculative interference attacks; describe a simple defense mechanism with a high performance cost; and discuss how future research can improve its performance.

Xiang Zou, Lie Yao, Donghua Zhao et al.

Objective: Brain is a fantastic organ that helps creature adapting to the environment. Network is the most essential structure of brain, but the capability of a simple network is still not very clear. In this study, we try to expound some brain functions only by the network property. Methods: Every network can be equivalent to a simplified network, which is expressed by an equation set. The dynamic of the equation set can be described by some basic equations, which is based on the mathematical derivation. Results (1) In a closed network, the stability is based on the excitatory/inhibitory synapse proportion. Spike probabilities in the assembly can meet the solution of a nonlinear equation set. (2) Network activity can spontaneously evolve into a certain distribution under different stimulation, which is closely related to decision making. (3) Short memory can be formed by coupling of network assemblies. Conclusion: The essential property of a network may contribute to some important brain functions.