Murilo M. Marinho

Enduo Zhao, Murilo M. Marinho, Kanako Harada

Robotic assistance for experimental manipulation in the life sciences is expected to enable precise manipulation of valuable samples, regardless of the skill of the scientist. Experimental specimens in the life sciences are subject to individual variability and deformation, and therefore require autonomous robotic control. As an example, we are studying the installation of a cranial window in a mouse. This operation requires the removal of the skull, which is approximately 300 um thick, to cut it into a circular shape 8 mm in diameter, but the shape of the mouse skull varies depending on the strain of mouse, sex and week of age. The thickness of the skull is not uniform, with some areas being thin and others thicker. It is also difficult to ensure that the skulls of the mice are kept in the same position for each operation. It is not realistically possible to measure all these features and pre-program a robotic trajectory for individual mice. The paper therefore proposes an autonomous robotic drilling method. The proposed method consists of drilling trajectory planning and image-based task completion level recognition. The trajectory planning adjusts the z-position of the drill according to the task completion level at each discrete point, and forms the 3D drilling path via constrained cubic spline interpolation while avoiding overshoot. The task completion level recognition uses a DSSD-inspired deep learning model to estimate the task completion level of each discrete point. Since an egg has similar characteristics to a mouse skull in terms of shape, thickness and mechanical properties, removing the egg shell without damaging the membrane underneath was chosen as the simulation task. The proposed method was evaluated using a 6-DOF robotic arm holding a drill and achieved a success rate of 80% out of 20 trials.

Enduo Zhao, Murilo M. Marinho, Kanako Harada

Robotic assistance for experimental manipulation in the life sciences is expected to enable favorable outcomes, regardless of the skill of the scientist. Experimental specimens in the life sciences are subject to individual variability and hence require intricate algorithms for successful autonomous robotic control. As a use case, we are studying the cranial window creation in mice. This operation requires the removal of an 8-mm circular patch of the skull, which is approximately 300 um thick, but the shape and thickness of the mouse skull significantly varies depending on the strain of the mouse, sex, and age. In this work, we develop an autonomous robotic drilling system with no offline planning, consisting of a trajectory planner with execution-time feedback with drilling completion level recognition based on image and force information. In the experiments, we first evaluate the image-and-force-based drilling completion level recognition by comparing it with other state-of-the-art deep learning image processing methods and conduct an ablation study in eggshell drilling to evaluate the impact of each module on system performance. Finally, the system performance is further evaluated in postmortem mice, achieving a success rate of 70% (14/20 trials) with an average drilling time of 9.3 min.

Yuki Koyama, Murilo M. Marinho, Mamoru Mitsuishi et al.

Vitreoretinal surgery is challenging even for expert surgeons owing to the delicate target tissues and the diminutive workspace in the retina. In addition to improved dexterity and accuracy, robot assistance allows for (partial) task automation. In this work, we propose a strategy to automate the motion of the light guide with respect to the surgical instrument. This automation allows the instrument's shadow to always be inside the microscopic view, which is an important cue for the accurate positioning of the instrument in the retina. We show simulations and experiments demonstrating that the proposed strategy is effective in a 700-point grid in the retina of a surgical phantom. Furthermore, we integrated the proposed strategy with image processing and succeeded in positioning the surgical instrument's tip in the retina, relying on only the robot's geometric information and microscopic images.

Murilo M. Marinho, Kanako Harada, Kyoichi Deie et al.

Commercially available surgical-robot technology currently addresses many surgical scenarios for adult patients. This same technology cannot be used to the benefit of neonate patients given the considerably smaller workspace. Medically relevant procedures regarding neonate patients include minimally invasive surgery to repair congenital esophagus disorders, which entail the suturing of the fragile esophagus within the narrow neonate cavity. In this work, we explore the use of the SmartArm robotic system in a feasibility study using a neonate chest and esophagus model. We show that a medically inexperienced operator can perform two-throw knots inside the neonate chest model using the robotic system.

Masakazu Yoshimura, Murilo M. Marinho, Kanako Harada et al.

Surgical robots are used to perform minimally invasive surgery and alleviate much of the burden imposed on surgeons. Our group has developed a surgical robot to aid in the removal of tumors at the base of the skull via access through the nostrils. To avoid injuring the patients, a collision-avoidance algorithm that depends on having an accurate model for the poses of the instruments' shafts is used. Given that the model's parameters can change over time owing to interactions between instruments and other disturbances, the online estimation of the poses of the instrument's shaft is essential. In this work, we propose a new method to estimate the pose of the surgical instruments' shafts using a monocular endoscope. Our method is based on the use of an automatically annotated training dataset and an improved pose-estimation deep-learning architecture. In preliminary experiments, we show that our method can surpass state of the art vision-based marker-less pose estimation techniques (providing an error decrease of 55% in position estimation, 64% in pitch, and 69% in yaw) by using artificial images.

Murilo M. Marinho, Bruno V. Adorno, Kanako Harada et al.

In adult laparoscopy, robot-aided surgery is a reality in thousands of operating rooms worldwide, owing to the increased dexterity provided by the robotic tools. Many robots and robot control techniques have been developed to aid in more challenging scenarios, such as pediatric surgery and microsurgery. However, the prevalence of case-specific solutions, particularly those focused on non-redundant robots, reduces the reproducibility of the initial results in more challenging scenarios. In this paper, we propose a general framework for the control of surgical robotics in constrained workspaces under teleoperation, regardless of the robot geometry. Our technique is divided into a slave-side constrained optimization algorithm, which provides virtual fixtures, and with Cartesian impedance on the master side to provide force feedback. Experiments with two robotic systems, one redundant and one non-redundant, show that smooth teleoperation can be achieved in adult laparoscopy and infant surgery.

Murilo M. Marinho, Bruno V. Adorno, Kanako Harada et al.

Robotic assistance allows surgeons to perform dexterous and tremor-free procedures, but robotic aid is still underrepresented in procedures with constrained workspaces, such as deep brain neurosurgery and endonasal surgery. In these procedures, surgeons have restricted vision to areas near the surgical tooltips, which increases the risk of unexpected collisions between the shafts of the instruments and their surroundings. In this work, our vector-field-inequalities method is extended to provide dynamic active-constraints to any number of robots and moving objects sharing the same workspace. The method is evaluated with experiments and simulations in which robot tools have to avoid collisions autonomously and in real-time, in a constrained endonasal surgical environment. Simulations show that with our method the combined trajectory error of two robotic systems is optimal. Experiments using a real robotic system show that the method can autonomously prevent collisions between the moving robots themselves and between the robots and the environment. Moreover, the framework is also successfully verified under teleoperation with tool-tissue interactions.

Murilo M. Marinho, Bruno V. Adorno, Kanako Harada et al.

Robotic assistance allows surgeons to perform dexterous and tremor-free procedures, but is still underrepresented in deep brain neurosurgery and endonasal surgery where the workspace is constrained. In these conditions, the vision of surgeons is restricted to areas near the surgical tool tips, which increases the risk of unexpected collisions between the shafts of the instruments and their surroundings, in particular in areas outside the surgical field-of-view. Active constraints can be used to prevent the tools from entering restricted zones and thus avoid collisions. In this paper, a vector field inequality is proposed that guarantees that tools do not enter restricted zones. Moreover, in contrast with early techniques, the proposed method limits the tool approach velocity in the direction of the forbidden zone boundary, guaranteeing a smooth behavior and that tangential velocities will not be disturbed. The proposed method is evaluated in simulations featuring two eight degrees-of-freedom manipulators that were custom-designed for deep neurosurgery. The results show that both manipulator-manipulator and manipulator-boundary collisions can be avoided using the vector field inequalities.