Yinan Jiang

Shirui Wang, Zhihui Tang, Huaxia Yang et al.

Large language models (LLMs) hold promise in clinical decision support but face major challenges in safety evaluation and effectiveness validation. We developed the Clinical Safety-Effectiveness Dual-Track Benchmark (CSEDB), a multidimensional framework built on clinical expert consensus, encompassing 30 criteria covering critical areas like critical illness recognition, guideline adherence, and medication safety, with weighted consequence measures. Thirty-two specialist physicians developed and reviewed 2,069 open-ended Q&A items aligned with these criteria, spanning 26 clinical departments to simulate real-world scenarios. Benchmark testing of six LLMs revealed moderate overall performance (average total score 57.2%, safety 54.7%, effectiveness 62.3%), with a significant 13.3% performance drop in high-risk scenarios (p < 0.0001). Domain-specific medical LLMs showed consistent performance advantages over general-purpose models, with relatively higher top scores in safety (0.912) and effectiveness (0.861). The findings of this study not only provide a standardized metric for evaluating the clinical application of medical LLMs, facilitating comparative analyses, risk exposure identification, and improvement directions across different scenarios, but also hold the potential to promote safer and more effective deployment of large language models in healthcare environments.

Linjun Zhou, Peng Cui, Yinan Jiang et al.

Black-box adversarial attack has attracted a lot of research interests for its practical use in AI safety. Compared with the white-box attack, a black-box setting is more difficult for less available information related to the attacked model and the additional constraint on the query budget. A general way to improve the attack efficiency is to draw support from a pre-trained transferable white-box model. In this paper, we propose a novel setting of transferable black-box attack: attackers may use external information from a pre-trained model with available network parameters, however, different from previous studies, no additional training data is permitted to further change or tune the pre-trained model. To this end, we further propose a new algorithm, EigenBA to tackle this problem. Our method aims to explore more gradient information of the black-box model, and promote the attack efficiency, while keeping the perturbation to the original attacked image small, by leveraging the Jacobian matrix of the pre-trained white-box model. We show the optimal perturbations are closely related to the right singular vectors of the Jacobian matrix. Further experiments on ImageNet and CIFAR-10 show that even the unlearnable pre-trained white-box model could also significantly boost the efficiency of the black-box attack and our proposed method could further improve the attack efficiency.