Yanjie Wei

Fangyu Zhang, Yanjie Wei, Jin Liu et al.

The development of noninvasive brain imaging such as resting-state functional magnetic resonance imaging (rs-fMRI) and its combination with AI algorithm provides a promising solution for the early diagnosis of Autism spectrum disorder (ASD). However, the performance of the current ASD classification based on rs-fMRI still needs to be improved. This paper introduces a classification framework to aid ASD diagnosis based on rs-fMRI. In the framework, we proposed a novel filter feature selection method based on the difference between step distribution curves (DSDC) to select remarkable functional connectivities (FCs) and utilized a multilayer perceptron (MLP) which was pretrained by a simplified Variational Autoencoder (VAE) for classification. We also designed a pipeline consisting of a normalization procedure and a modified hyperbolic tangent (tanh) activation function to replace the original tanh function, further improving the model accuracy. Our model was evaluated by 10 times 10-fold cross-validation and achieved an average accuracy of 78.12%, outperforming the state-of-the-art methods reported on the same dataset. Given the importance of sensitivity and specificity in disease diagnosis, two constraints were designed in our model which can improve the model's sensitivity and specificity by up to 9.32% and 10.21%, respectively. The added constraints allow our model to handle different application scenarios and can be used broadly.

Ruimin Ma, Yanlin Wang, Yanjie Wei et al.

Accurate diagnosis of autism spectrum disorder (ASD) based on neuroimaging data has significant implications, as extracting useful information from neuroimaging data for ASD detection is challenging. Even though machine learning techniques have been leveraged to improve the information extraction from neuroimaging data, the varying data quality caused by different meta-data conditions (i.e., data collection strategies) limits the effective information that can be extracted, thus leading to data-dependent predictive accuracies in ASD detection, which can be worse than random guess in some cases. In this work, we systematically investigate the impact of three kinds of meta-data on the predictive accuracy of classifying ASD based on structural MRI collected from 20 different sites, where meta-data conditions vary.

Ruimin Ma, Ruitao Xie, Yanlin Wang et al.

Autism spectrum disorder (ASD) is a highly disabling mental disease that brings significant impairments of social interaction ability to the patients, making early screening and intervention of ASD critical. With the development of the machine learning and neuroimaging technology, extensive research has been conducted on machine classification of ASD based on structural Magnetic Resonance Imaging (s-MRI). However, most studies involve with datasets where participants' age are above 5 and lack interpretability. In this paper, we propose a machine learning method for ASD classification in children with age range from 0.92 to 4.83 years, based on s-MRI features extracted using contrastive variational autoencoder (CVAE). 78 s-MRIs, collected from Shenzhen Children's Hospital, are used for training CVAE, which consists of both ASD-specific feature channel and common shared feature channel. The ASD participants represented by ASD-specific features can be easily discriminated from TC participants represented by the common shared features. In case of degraded predictive accuracy when data size is extremely small, a transfer learning strategy is proposed here as a potential solution. Finally, we conduct neuroanatomical interpretation based on the correlation between s-MRI features extracted from CVAE and surface area of different cortical regions, which discloses potential biomarkers that could help target treatments of ASD in the future.

Xiaoqing Zhang, Qiushi Nie, Zunjie Xiao et al.

Spatial pooling (SP) and cross-channel pooling (CCP) operators have been applied to aggregate spatial features and pixel-wise features from feature maps in deep neural networks (DNNs), respectively. Their main goal is to reduce computation and memory overhead without visibly weakening the performance of DNNs. However, SP often faces the problem of losing the subtle feature representations, while CCP has a high possibility of ignoring salient feature representations, which may lead to both miscalibration of confidence issues and suboptimal medical classification results. To address these problems, we propose a novel dual-view framework, the first to systematically investigate the relative roles of SP and CCP by analyzing the difference between spatial features and pixel-wise features. Based on this framework, we propose a new pooling method, termed dual-view pyramid pooling (DVPP), to aggregate multi-scale dual-view features. DVPP aims to boost both medical image classification and confidence calibration performance by fully leveraging the merits of SP and CCP operators from a dual-axis perspective. Additionally, we discuss how to fulfill DVPP with five parameter-free implementations. Extensive experiments on six 2D/3D medical image classification tasks show that our DVPP surpasses state-of-the-art pooling methods in terms of medical image classification results and confidence calibration across different DNNs.

Rui Zhou, Haohui Ma, Tianle Xin et al.

The rapid expansion of enzyme kinetics literature has outpaced the curation capabilities of major biochemical databases, creating a substantial barrier to AI-driven modeling and knowledge discovery. We present zERExtractor, an automated and extensible platform for comprehensive extraction of enzyme-catalyzed reaction and activity data from scientific literature. zERExtractor features a unified, modular architecture that supports plug-and-play integration of state-of-the-art models, including large language models (LLMs), as interchangeable components, enabling continuous system evolution alongside advances in AI. Our pipeline combines domain-adapted deep learning, advanced OCR, semantic entity recognition, and prompt-driven LLM modules, together with human expert corrections, to extract kinetic parameters (e.g., kcat, Km), enzyme sequences, substrate SMILES, experimental conditions, and molecular diagrams from heterogeneous document formats. Through active learning strategies integrating AI-assisted annotation, expert validation, and iterative refinement, the system adapts rapidly to new data sources. We also release a large benchmark dataset comprising over 1,000 annotated tables and 5,000 biological fields from 270 P450-related enzymology publications. Benchmarking demonstrates that zERExtractor consistently outperforms existing baselines in table recognition (Acc 89.9%), molecular image interpretation (up to 99.1%), and relation extraction (accuracy 94.2%). zERExtractor bridges the longstanding data gap in enzyme kinetics with a flexible, plugin-ready framework and high-fidelity extraction, laying the groundwork for future AI-powered enzyme modeling and biochemical knowledge discovery.

Mingyu Yu, Wei Wang, Yanjie Wei et al.

Recent advancements in adversarial jailbreak attacks have exposed critical vulnerabilities in Large Language Models (LLMs), enabling the circumvention of alignment safeguards through increasingly sophisticated prompt manipulations. Based on our experiments, we found that the effectiveness of jailbreak strategies is influenced by the comprehension ability of the attacked LLM. Building on this insight, we propose a capability-aware Multi-Encryption Framework (MEF) for evaluating vulnerabilities in black-box LLMs. Specifically, MEF first categorizes the comprehension ability level of the LLM, then applies different strategies accordingly: For models with limited comprehension ability, MEF adopts the Fu+En1 strategy, which integrates layered semantic mutations with an encryption technique, more effectively contributing to evasion of the LLM's defenses at the input and inference stages. For models with strong comprehension ability, MEF uses a more complex Fu+En1+En2 strategy, in which additional dual-ended encryption techniques are applied to the LLM's responses, further contributing to evasion of the LLM's defenses at the output stage. Experimental results demonstrate the effectiveness of our approach, achieving attack success rates of 98.9% on GPT-4o (29 May 2025 release) and 99.8% on GPT-4.1 (8 July 2025 release). Our work contributes to a deeper understanding of the vulnerabilities in current LLM alignment mechanisms.

Xi Chen, Hongzhi Wang, Yanjie Wei et al.

Time series prediction with missing values is an important problem of time series analysis since complete data is usually hard to obtain in many real-world applications. To model the generation of time series, autoregressive (AR) model is a basic and widely used one, which assumes that each observation in the time series is a noisy linear combination of some previous observations along with a constant shift. To tackle the problem of prediction with missing values, a number of methods were proposed based on various data models. For real application scenarios, how do these methods perform over different types of time series with different levels of data missing remains to be investigated. In this paper, we focus on online methods for AR-model-based time series prediction with missing values. We adapted five mainstream methods to fit in such a scenario. We make detailed discussion on each of them by introducing their core ideas about how to estimate the AR coefficients and their different strategies to deal with missing values. We also present algorithmic implementations for better understanding. In order to comprehensively evaluate these methods and do the comparison, we conduct experiments with various configurations of relative parameters over both synthetic and real data. From the experimental results, we derived several noteworthy conclusions and shows that imputation is a simple but reliable strategy to handle missing values in online prediction tasks.