Alex Leow

Xuetong Wang, Kanhao Zhao, Rong Zhou et al.

Normative modeling is an emerging and promising approach to effectively study disorder heterogeneity in individual participants. In this study, we propose a novel normative modeling method by combining conditional variational autoencoder with adversarial learning (ACVAE) to identify brain dysfunction in Alzheimer's Disease (AD). Specifically, we first train a conditional VAE on the healthy control (HC) group to create a normative model conditioned on covariates like age, gender and intracranial volume. Then we incorporate an adversarial training process to construct a discriminative feature space that can better generalize to unseen data. Finally, we compute deviations from the normal criterion at the patient level to determine which brain regions were associated with AD. Our experiments on OASIS-3 database show that the deviation maps generated by our model exhibit higher sensitivity to AD compared to other deep normative models, and are able to better identify differences between the AD and HC groups.

Carlo Amodeo, Igor Fortel, Olusola Ajilore et al.

Graph theoretical analyses have become standard tools in modeling functional and anatomical connectivity in the brain. With the advent of connectomics, the primary graphs or networks of interest are structural connectome (derived from DTI tractography) and functional connectome (derived from resting-state fMRI). However, most published connectome studies have focused on either structural or functional connectome, yet complementary information between them, when available in the same dataset, can be jointly leveraged to improve our understanding of the brain. To this end, we propose a function-constrained structural graph variational autoencoder (FCS-GVAE) capable of incorporating information from both functional and structural connectome in an unsupervised fashion. This leads to a joint low-dimensional embedding that establishes a unified spatial coordinate system for comparing across different subjects. We evaluate our approach using the publicly available OASIS-3 Alzheimer's disease (AD) dataset and show that a variational formulation is necessary to optimally encode functional brain dynamics. Further, the proposed joint embedding approach can more accurately distinguish different patient sub-populations than approaches that do not use complementary connectome information.

Haoteng Tang, Xiyao Fu, Lei Guo et al.

MRI-based modeling of brain networks has been widely used to understand functional and structural interactions and connections among brain regions, and factors that affect them, such as brain development and disease. Graph mining on brain networks may facilitate the discovery of novel biomarkers for clinical phenotypes and neurodegenerative diseases. Since brain networks derived from functional and structural MRI describe the brain topology from different perspectives, exploring a representation that combines these cross-modality brain networks is non-trivial. Most current studies aim to extract a fused representation of the two types of brain network by projecting the structural network to the functional counterpart. Since the functional network is dynamic and the structural network is static, mapping a static object to a dynamic object is suboptimal. However, mapping in the opposite direction is not feasible due to the non-negativity requirement of current graph learning techniques. Here, we propose a novel graph learning framework, known as Deep Signed Brain Networks (DSBN), with a signed graph encoder that, from an opposite perspective, learns the cross-modality representations by projecting the functional network to the structural counterpart. We validate our framework on clinical phenotype and neurodegenerative disease prediction tasks using two independent, publicly available datasets (HCP and OASIS). The experimental results clearly demonstrate the advantages of our model compared to several state-of-the-art methods.

Haoteng Tang, Guodong Liu, Siyuan Dai et al.

The MRI-derived brain network serves as a pivotal instrument in elucidating both the structural and functional aspects of the brain, encompassing the ramifications of diseases and developmental processes. However, prevailing methodologies, often focusing on synchronous BOLD signals from functional MRI (fMRI), may not capture directional influences among brain regions and rarely tackle temporal functional dynamics. In this study, we first construct the brain-effective network via the dynamic causal model. Subsequently, we introduce an interpretable graph learning framework termed Spatio-Temporal Embedding ODE (STE-ODE). This framework incorporates specifically designed directed node embedding layers, aiming at capturing the dynamic interplay between structural and effective networks via an ordinary differential equation (ODE) model, which characterizes spatial-temporal brain dynamics. Our framework is validated on several clinical phenotype prediction tasks using two independent publicly available datasets (HCP and OASIS). The experimental results clearly demonstrate the advantages of our model compared to several state-of-the-art methods.

Jun Yu, Zhaoming Kong, Aditya Kendre et al.

This paper presents a novel graph-based kernel learning approach for connectome analysis. Specifically, we demonstrate how to leverage the naturally available structure within the graph representation to encode prior knowledge in the kernel. We first proposed a matrix factorization to directly extract structural features from natural symmetric graph representations of connectome data. We then used them to derive a structure-persevering graph kernel to be fed into the support vector machine. The proposed approach has the advantage of being clinically interpretable. Quantitative evaluations on challenging HIV disease classification (DTI- and fMRI-derived connectome data) and emotion recognition (EEG-derived connectome data) tasks demonstrate the superior performance of our proposed methods against the state-of-the-art. Results showed that relevant EEG-connectome information is primarily encoded in the alpha band during the emotion regulation task.

Ran Xu, Manu Mathew Thomas, Alex Leow et al.

We introduce TempoCave, a novel visualization application for analyzing dynamic brain networks, or connectomes. TempoCave provides a range of functionality to explore metrics related to the activity patterns and modular affiliations of different regions in the brain. These patterns are calculated by processing raw data retrieved functional magnetic resonance imaging (fMRI) scans, which creates a network of weighted edges between each brain region, where the weight indicates how likely these regions are to activate synchronously. In particular, we support the analysis needs of clinical psychologists, who examine these modular affiliations and weighted edges and their temporal dynamics, utilizing them to understand relationships between neurological disorders and brain activity, which could have a significant impact on the way in which patients are diagnosed and treated. We summarize the core functionality of TempoCave, which supports a range of comparative tasks, and runs both in a desktop mode and in an immersive mode. Furthermore, we present a real-world use case that analyzes pre- and post-treatment connectome datasets from 27 subjects in a clinical study investigating the use of cognitive behavior therapy to treat major depression disorder, indicating that TempoCave can provide new insight into the dynamic behavior of the human brain.

Lubna Shibly Mokatren, Rashid Ansari, Ahmet Enis Cetin et al.

Electroencephalography (EEG) serves as an effective diagnostic tool for mental disorders and neurological abnormalities. Enhanced analysis and classification of EEG signals can help improve detection performance. A new approach is examined here for enhancing EEG classification performance by leveraging knowledge of spatial layout of EEG sensors. Performance of two classification models - model 1 that ignores the sensor layout and model 2 that factors it in - is investigated and found to achieve consistently higher detection accuracy. The analysis is based on the information content of these signals represented in two different ways: concatenation of the channels of the frequency bands and an image-like 2D representation of the EEG channel locations. Performance of these models is examined on two tasks, social anxiety disorder (SAD) detection, and emotion recognition using a dataset for emotion analysis using physiological signals (DEAP). We hypothesized that model 2 will significantly outperform model 1 and this was validated in our results as model 2 yielded $5$--$8\%$ higher accuracy in all machine learning algorithms investigated. Convolutional Neural Networks (CNN) provided the best performance far exceeding that of Support Vector Machine (SVM) and k-Nearest Neighbors (kNNs) algorithms.

Lubna Shibly Mokatren, Rashid Ansari, Ahmet Enis Cetin et al.

The problem of detecting the presence of Social Anxiety Disorder (SAD) using Electroencephalography (EEG) for classification has seen limited study and is addressed with a new approach that seeks to exploit the knowledge of EEG sensor spatial configuration. Two classification models, one which ignores the configuration (model 1) and one that exploits it with different interpolation methods (model 2), are studied. Performance of these two models is examined for analyzing 34 EEG data channels each consisting of five frequency bands and further decomposed with a filter bank. The data are collected from 64 subjects consisting of healthy controls and patients with SAD. Validity of our hypothesis that model 2 will significantly outperform model 1 is borne out in the results, with accuracy $6$--$7\%$ higher for model 2 for each machine learning algorithm we investigated. Convolutional Neural Networks (CNN) were found to provide much better performance than SVM and kNNs.

He Huang, Bokai Cao, Philip S. Yu et al.

Mood disorders are common and associated with significant morbidity and mortality. Early diagnosis has the potential to greatly alleviate the burden of mental illness and the ever increasing costs to families and society. Mobile devices provide us a promising opportunity to detect the users' mood in an unobtrusive manner. In this study, we use a custom keyboard which collects keystrokes' meta-data and accelerometer values. Based on the collected time series data in multiple modalities, we propose a deep personalized mood prediction approach, called {\pro}, by integrating convolutional and recurrent deep architectures as well as exploring each individual's circadian rhythm. Experimental results not only demonstrate the feasibility and effectiveness of using smart-phone meta-data to predict the presence and severity of mood disturbances in bipolar subjects, but also show the potential of personalized medical treatment for mood disorders.

Ye Liu, Lifang He, Bokai Cao et al.

Network analysis of human brain connectivity is critically important for understanding brain function and disease states. Embedding a brain network as a whole graph instance into a meaningful low-dimensional representation can be used to investigate disease mechanisms and inform therapeutic interventions. Moreover, by exploiting information from multiple neuroimaging modalities or views, we are able to obtain an embedding that is more useful than the embedding learned from an individual view. Therefore, multi-view multi-graph embedding becomes a crucial task. Currently, only a few studies have been devoted to this topic, and most of them focus on the vector-based strategy which will cause structural information contained in the original graphs lost. As a novel attempt to tackle this problem, we propose Multi-view Multi-graph Embedding (M2E) by stacking multi-graphs into multiple partially-symmetric tensors and using tensor techniques to simultaneously leverage the dependencies and correlations among multi-view and multi-graph brain networks. Extensive experiments on real HIV and bipolar disorder brain network datasets demonstrate the superior performance of M2E on clustering brain networks by leveraging the multi-view multi-graph interactions.

Bokai Cao, Lei Zheng, Chenwei Zhang et al.

The increasing use of electronic forms of communication presents new opportunities in the study of mental health, including the ability to investigate the manifestations of psychiatric diseases unobtrusively and in the setting of patients' daily lives. A pilot study to explore the possible connections between bipolar affective disorder and mobile phone usage was conducted. In this study, participants were provided a mobile phone to use as their primary phone. This phone was loaded with a custom keyboard that collected metadata consisting of keypress entry time and accelerometer movement. Individual character data with the exceptions of the backspace key and space bar were not collected due to privacy concerns. We propose an end-to-end deep architecture based on late fusion, named DeepMood, to model the multi-view metadata for the prediction of mood scores. Experimental results show that 90.31% prediction accuracy on the depression score can be achieved based on session-level mobile phone typing dynamics which is typically less than one minute. It demonstrates the feasibility of using mobile phone metadata to infer mood disturbance and severity.

Lichao Sun, Yuqi Wang, Bokai Cao et al.

With the rapid growth in smartphone usage, more organizations begin to focus on providing better services for mobile users. User identification can help these organizations to identify their customers and then cater services that have been customized for them. Currently, the use of cookies is the most common form to identify users. However, cookies are not easily transportable (e.g., when a user uses a different login account, cookies do not follow the user). This limitation motivates the need to use behavior biometric for user identification. In this paper, we propose DEEPSERVICE, a new technique that can identify mobile users based on user's keystroke information captured by a special keyboard or web browser. Our evaluation results indicate that DEEPSERVICE is highly accurate in identifying mobile users (over 93% accuracy). The technique is also efficient and only takes less than 1 ms to perform identification.

Johnson J. G. Keiriz, Liang Zhan, Morris Chukhman et al.

Visually comparing brain networks, or connectomes, is an essential task in the field of neuroscience. Especially relevant to the field of clinical neuroscience, group studies that examine differences between populations or changes over time within a population enable neuroscientists to reason about effective diagnoses and treatments for a range of neuropsychiatric disorders. In this paper, we specifically explore how visual analytics tools can be used to facilitate various clinical neuroscience tasks, in which observation and analysis of meaningful patterns in the connectome can support patient diagnosis and treatment. We conduct a survey of visualization tasks that enable clinical neuroscience activities, and further explore how existing connectome visualization tools support or fail to support these tasks. Based on our investigation of these tasks, we introduce a novel visualization tool, NeuroCave, to support group studies analyses. We discuss how our design decisions (the use of immersive visualization, the use of hierarchical clustering and dimensionality reduction techniques, and the choice of visual encodings) are motivated by these tasks. We evaluate NeuroCave through two use cases that illustrate the utility of interactive connectome visualization in clinical neuroscience contexts. In the first use case, we study sex differences using functional connectomes and discover hidden connectome patterns associated with well-known cognitive differences in spatial and verbal abilities. In the second use case, we show how the utility of visualizing the brain in different topological space coupled with clustering information can reveal the brain's intrinsic structure.