Kai Riemer

Kai Riemer, Marcelo Lerendegui, Matthieu Toulemonde et al.

Filtering based on Singular Value Decomposition (SVD) provides substantial separation of clutter, flow and noise in high frame rate ultrasound flow imaging. The use of SVD as a clutter filter has greatly improved techniques such as vector flow imaging, functional ultrasound and super-resolution ultrasound localization microscopy. The removal of clutter and noise relies on the assumption that tissue, flow and noise are each represented by different subsets of singular values, so that their signals are uncorrelated and lay on orthogonal sub-spaces. This assumption fails in the presence of tissue motion, for near-wall or microvascular flow, and can be influenced by an incorrect choice of singular value thresholds. Consequently, separation of flow, clutter and noise is imperfect, which can lead to image artefacts not present in the original data. Temporal and spatial fluctuation in intensity are the commonest artefacts, which vary in appearance and strengths. Ghosting and splitting artefacts are observed in the microvasculature where the flow signal is sparsely distributed. Singular value threshold selection, tissue motion, frame rate, flow signal amplitude and acquisition length affect the prevalence of these artefacts. Understanding what causes artefacts due to SVD clutter and noise removal is necessary for their interpretation.

Su Yan, Clara Rodrigo Gonzalez, Vincent C. H. Leung et al.

Super-resolution ultrasound via microbubble (MB) localisation and tracking, also known as ultrasound localisation microscopy (ULM), can resolve microvasculature beyond the acoustic diffraction limit. However, significant challenges remain in localisation performance and data acquisition and processing time. Deep learning methods for ULM have shown promise to address these challenges, however, they remain limited by in vivo label scarcity and the simulation-to-reality domain gap. We present CycleULM, the first unified label-free deep learning framework for ULM. CycleULM learns a physics-emulating translation between the real contrast-enhanced ultrasound (CEUS) data domain and a simplified MB-only domain, leveraging the power of CycleGAN without requiring paired ground truth data. With this translation, CycleULM removes dependence on high-fidelity simulators or labelled data, and makes MB localisation and tracking substantially easier. Deployed as modular plug-and-play components within existing pipelines or as an end-to-end processing framework, CycleULM delivers substantial performance gains across both in silico and in vivo datasets. Specifically, CycleULM improves image contrast (contrast-to-noise ratio) by up to 15.3 dB and sharpens CEUS resolution with a 2.5{\times} reduction in the full width at half maximum of the point spread function. CycleULM also improves MB localisation performance, with up to +40% recall, +46% precision, and a -14.0 μm mean localisation error, yielding more faithful vascular reconstructions. Importantly, CycleULM achieves real-time processing throughput at 18.3 frames per second with order-of-magnitude speed-ups (up to ~14.5{\times}). By combining label-free learning, performance enhancement, and computational efficiency, CycleULM provides a practical pathway toward robust, real-time ULM and accelerates its translation to clinical applications.

Lenard Strahringer, Sven Eric Prüß, Kai Riemer

Generalized reciprocity -- the tendency to help others after receiving help oneself -- is widely theorized as a mechanism sustaining cooperation on online knowledge-sharing platforms. Yet robust empirical evidence from field settings remains surprisingly scarce. Prior studies relying on survey self-reports struggle to distinguish reciprocity from other prosocial motives, while observational designs confound reciprocity with baseline user activity, producing upward-biased estimates. We address these empirical challenges by developing a matched difference-in-differences survival analysis that leverages the temporal structure of help-seeking and help-giving on Stack Overflow. Using Cox proportional hazards models on over 21 million questions, we find that receiving an answer significantly increases a user's propensity to help others, but this effect is concentrated among newcomers and declines with platform experience. This pattern suggests that reciprocity functions primarily as a contributor-recruitment mechanism, operating before platform-specific incentives such as reputation and status displace the general moral impulse to reciprocate. Response time moderates the effect, but non-linearly: reciprocity peaks for answers arriving within a re-engagement window of roughly thirty to sixty minutes. These findings contribute to the theory of generalized reciprocity and have implications for platform design.