Dong Xue

Dong Xue, Jicheng Tu, Ming Wang et al.

Large language models (LLMs) have shown promise for mental health support, yet training such models is constrained by the scarcity and sensitivity of real counseling dialogues. In this article, we present MindChat, a privacy-preserving LLM for mental health support, together with MindCorpus, a synthetic multi-turn counseling dataset constructed via a multi-agent role-playing framework. To synthesize high-quality counseling data, the developed dialogue-construction framework employs a dual closed-loop feedback design to integrate psychological expertise and counseling techniques through role-playing: (i) turn-level critique-and-revision to improve coherence and counseling appropriateness within a session, and (ii) session-level strategy refinement to progressively enrich counselor behaviors across sessions. To mitigate privacy risks under decentralized data ownership, we fine-tune the base model using federated learning with parameter-efficient LoRA adapters and incorporate differentially private optimization to reduce membership and memorization risks. Experiments on synthetic-data quality assessment and counseling capability evaluation show that MindCorpus improves training effectiveness and that MindChat is competitive with existing general and counseling-oriented LLM baselines under both automatic LLM-judge and human evaluation protocols, while exhibiting reduced privacy leakage under membership inference attacks.

Dong Xue, Ziyao Shao, Zhaoyang Duan et al.

Large multimodal models (LMMs) have demonstrated significant potential in providing innovative solutions for various biomedical tasks, including pathology analysis, radiology report generation, and biomedical assistance. However, the existing multimodal biomedical AI is typically based on foundation LLMs, thus hindering the understanding of intricate medical concepts with limited medical training data. Moreover, recent LLaVA-induced medical LMMs struggle to effectively capture the intricate relationship between the texts and the images. Therefore, we introduce Doctor Sun, a large multimodal generative model specialized in medicine, developed to encode, integrate, and interpret diverse biomedical data modalities such as text and images. In particular, Doctor Sun integrates a pre-trained vision encoder with a medical LLM and conducts two-stage training on various medical datasets, focusing on feature alignment and instruction tuning. Moreover, we release SunMed-VL, a wide-range bilingual medical multimodal dataset, along with all associated models, code, and resources, to freely support the advancement of biomedical multimodal research.

Ming Wang, Zhaoyang Duan, Dong Xue et al.

The labor-intensive nature of medical data annotation presents a significant challenge for respiratory disease diagnosis, resulting in a scarcity of high-quality labeled datasets in resource-constrained settings. Moreover, patient privacy concerns complicate the direct sharing of local medical data across institutions, and existing centralized data-driven approaches, which rely on amounts of available data, often compromise data privacy. This study proposes a federated few-shot learning framework with privacy-preserving mechanisms to address the issues of limited labeled data and privacy protection in diagnosing respiratory diseases. In particular, a meta-stochastic gradient descent algorithm is proposed to mitigate the overfitting problem that arises from insufficient data when employing traditional gradient descent methods for neural network training. Furthermore, to ensure data privacy against gradient leakage, differential privacy noise from a standard Gaussian distribution is integrated into the gradients during the training of private models with local data, thereby preventing the reconstruction of medical images. Given the impracticality of centralizing respiratory disease data dispersed across various medical institutions, a weighted average algorithm is employed to aggregate local diagnostic models from different clients, enhancing the adaptability of a model across diverse scenarios. Experimental results show that the proposed method yields compelling results with the implementation of differential privacy, while effectively diagnosing respiratory diseases using data from different structures, categories, and distributions.

Ang Chen, Bifeng Song, Zhihe Wang et al.

Flying vertebrates exhibit sophisticated wingbeat kinematics. Their specialized forelimbs allow for the wing morphing motion to couple with the flapping motion during their level flight, Previous flyable bionic platforms have successfully applied bio-inspired wing morphing but cannot yet be propelled by the morphing-coupled wingbeat pattern. Spurred by this, we develop a bio-inspired flapping-wing aerial vehicle (FWAV) entitled RoboFalcon, which is equipped with a novel mechanism to drive the bat-style morphing wings, performs a morphing-coupled wingbeat pattern, and overall manages an appealing flight. The novel mechanism of RoboFalcon allows coupling the morphing and flapping during level flight and decoupling these when maneuvering is required, producing a bilateral asymmetric downstroke affording high rolling agility. The bat-style morphing wing is designed with a tilted mounting angle around the radius at the wrist joint to mimic the wrist supination and pronation effect of flying vertebrates' forelimbs. The agility of RoboFalcon is assessed through several rolling maneuver flight tests, and we demonstrate its well-performing agility capability compared to flying creatures and current flapping-wing platforms. Wind tunnel tests indicate that the roll moment of the asymmetric downstroke is correlated with the flapping frequency, and the wrist mounting angle can be used for tuning the angle of attack and lift-thrust configuration of the equilibrium flight state. We believe that this work yields a well-performing bionic platform and provides a new actuation strategy for the morphing-coupled flapping flight.

Jia Guo, Yuxuan Mu, Dong Xue et al.

Calcaneus is the largest tarsal bone to withstand the daily stresses of weight-bearing. The calcaneal fracture is the most common type in the tarsal bone fractures. After a fracture is suspected, plain radiographs should be taken first. Bohler's Angle (BA) and Critical Angle of Gissane (CAG), measured by four anatomic landmarks in lateral foot radiograph, can guide fracture diagnosis and facilitate operative recovery of the fractured calcaneus. This study aims to develop an analysis system that can automatically locate four anatomic landmarks, measure BA and CAG for fracture assessment, identify fractured calcaneus, and segment fractured regions. For landmark detection, we proposed a coarse-to-fine Rotation-Invariant Regression-Voting (RIRV) landmark detection method based on regressive Multi-Layer Perceptron (MLP) and Scale Invariant Feature Transform (SIFT) patch descriptor, which solves the problem of fickle rotation of calcaneus. By implementing a novel normalization approach, the RIRV method is explicitly rotation-invariance comparing with traditional regressive methods. For fracture identification and segmentation, a convolution neural network (CNN) based on U-Net with auxiliary classification head (U-Net-CH) is designed. The input ROIs of the CNN are normalized by detected landmarks to uniform view, orientation, and scale. The advantage of this approach is the multi-task learning that combines classification and segmentation. Our system can accurately measure BA and CAG with a mean angle error of 3.8 and 6.2 respectively. For fracture identification and fracture region segmentation, our system presents good performance with an F1-score of 96.55%, recall of 94.99%, and segmentation IoU-score of 0.586.