Daniel Szelogowski

Daniel Szelogowski

Music is a complex auditory stimulus capable of eliciting significant changes in brain activity, influencing cognitive processes such as memory, attention, and emotional regulation. However, the underlying mechanisms of music-induced cognitive processes remain largely unknown. Organoid intelligence and deep learning models show promise for simulating and analyzing these neural responses to classical music, an area significantly unexplored in computational neuroscience. Hence, we present the PyOrganoid library, an innovative tool that facilitates the simulation of organoid learning models, integrating sophisticated machine learning techniques with biologically inspired organoid simulations. Our study features the development of the Pianoid model, a "deep organoid learning" model that utilizes a Bidirectional LSTM network to predict EEG responses based on audio features from classical music recordings. This model demonstrates the feasibility of using computational methods to replicate complex neural processes, providing valuable insights into music perception and cognition. Likewise, our findings emphasize the utility of synthetic models in neuroscience research and highlight the PyOrganoid library's potential as a versatile tool for advancing studies in neuroscience and artificial intelligence.

Daniel Szelogowski

Despite substantial research into the biological basis of memory, the precise mechanisms by which experiences are encoded, stored, and retrieved in the brain remain incompletely understood. A growing body of evidence supports the engram theory, which posits that sparse populations of neurons undergo lasting physical and biochemical changes to support long-term memory. Yet, a comprehensive computational framework that integrates biological findings with mechanistic models remains elusive. This work synthesizes insights from cellular neuroscience and computational modeling to address key challenges in engram research: how engram neurons are identified and manipulated; how synaptic plasticity mechanisms contribute to stable memory traces; and how sparsity promotes efficient, interference-resistant representations. Relevant computational approaches -- such as sparse regularization, engram gating, and biologically inspired architectures like Sparse Distributed Memory and spiking neural networks -- are also examined. Together, these findings suggest that memory efficiency, capacity, and stability emerge from the interaction of plasticity and sparsity constraints. By integrating neurobiological and computational perspectives, this paper provides a comprehensive theoretical foundation for engram research and proposes a roadmap for future inquiry into the mechanisms underlying memory, with implications for the diagnosis and treatment of memory-related disorders.

Daniel Szelogowski

Despite success across diverse tasks, current artificial recurrent network architectures rely primarily on implicit hidden-state memories, limiting their interpretability and ability to model long-range dependencies. In contrast, biological neural systems employ explicit, associative memory traces (i.e., engrams) strengthened through Hebbian synaptic plasticity and activated sparsely during recall. Motivated by these neurobiological insights, we introduce the Engram Neural Network (ENN), a novel recurrent architecture incorporating an explicit, differentiable memory matrix with Hebbian plasticity and sparse, attention-driven retrieval mechanisms. The ENN explicitly models memory formation and recall through dynamic Hebbian traces, improving transparency and interpretability compared to conventional RNN variants. We evaluate the ENN architecture on three canonical benchmarks: MNIST digit classification, CIFAR-10 image sequence modeling, and WikiText-103 language modeling. Our empirical results demonstrate that the ENN achieves accuracy and generalization performance broadly comparable to classical RNN, GRU, and LSTM architectures, with all models converging to similar accuracy and perplexity on the large-scale WikiText-103 task. At the same time, the ENN offers significant enhancements in interpretability through observable memory dynamics. Hebbian trace visualizations further reveal biologically plausible, structured memory formation processes, validating the potential of neuroscience-inspired mechanisms to inform the development of more interpretable and robust deep learning models.

Daniel Szelogowski

Current computational-emotion research has focused on applying acoustic properties to analyze how emotions are perceived mathematically or used in natural language processing machine learning models. While recent interest has focused on analyzing emotions from the spoken voice, little experimentation has been performed to discover how emotions are recognized in the singing voice -- both in noiseless and noisy data (i.e., data that is either inaccurate, difficult to interpret, has corrupted/distorted/nonsense information like actual noise sounds in this case, or has a low ratio of usable/unusable information). Not only does this ignore the challenges of training machine learning models on more subjective data and testing them with much noisier data, but there is also a clear disconnect in progress between advancing the development of convolutional neural networks and the goal of emotionally cognizant artificial intelligence. By training a new model to include this type of information with a rich comprehension of psycho-acoustic properties, not only can models be trained to recognize information within extremely noisy data, but advancement can be made toward more complex biofeedback applications -- including creating a model which could recognize emotions given any human information (language, breath, voice, body, posture) and be used in any performance medium (music, speech, acting) or psychological assistance for patients with disorders such as BPD, alexithymia, autism, among others. This paper seeks to reflect and expand upon the findings of related research and present a stepping-stone toward this end goal.

Daniel Szelogowski

Current AI-generated music lacks fundamental principles of good compositional techniques. By narrowing down implementation issues both programmatically and musically, we can create a better understanding of what parameters are necessary for a generated composition nearly indistinguishable from that of a master composer.