Hao Huang

Jie Feng, Hao Huang, Junpeng Zhang et al.

Mainstreamed weakly supervised road extractors rely on highly confident pseudo-labels propagated from scribbles, and their performance often degrades gradually as the image scenes tend various. We argue that such degradation is due to the poor model's invariance to scenes with different complexities, whereas existing solutions to this problem are commonly based on crafted priors that cannot be derived from scribbles. To eliminate the reliance on such priors, we propose a novel Structure-aware Mixup and Invariance Learning framework (SA-MixNet) for weakly supervised road extraction that improves the model invariance in a data-driven manner. Specifically, we design a structure-aware Mixup scheme to paste road regions from one image onto another for creating an image scene with increased complexity while preserving the road's structural integrity. Then an invariance regularization is imposed on the predictions of constructed and origin images to minimize their conflicts, which thus forces the model to behave consistently on various scenes. Moreover, a discriminator-based regularization is designed for enhancing the connectivity meanwhile preserving the structure of roads. Combining these designs, our framework demonstrates superior performance on the DeepGlobe, Wuhan, and Massachusetts datasets outperforming the state-of-the-art techniques by 1.47%, 2.12%, 4.09% respectively in IoU metrics, and showing its potential of plug-and-play. The code will be made publicly available.

Sovesh Mohapatra, Minhui Ouyang, Shufang Tan et al.

Precise parcellation of functional networks (FNs) of early developing human brain is the fundamental basis for identifying biomarker of developmental disorders and understanding functional development. Resting-state fMRI (rs-fMRI) enables in vivo exploration of functional changes, but adult FN parcellations cannot be directly applied to the neonates due to incomplete network maturation. No standardized neonatal functional atlas is currently available. To solve this fundamental issue, we propose TReND, a novel and fully automated self-supervised transformer-autoencoder framework that integrates regularized nonnegative matrix factorization (RNMF) to unveil the FNs in neonates. TReND effectively disentangles spatiotemporal features in voxel-wise rs-fMRI data. The framework integrates confidence-adaptive masks into transformer self-attention layers to mitigate noise influence. A self supervised decoder acts as a regulator to refine the encoder's latent embeddings, which serve as reliable temporal features. For spatial coherence, we incorporate brain surface-based geodesic distances as spatial encodings along with functional connectivity from temporal features. The TReND clustering approach processes these features under sparsity and smoothness constraints, producing robust and biologically plausible parcellations. We extensively validated our TReND framework on three different rs-fMRI datasets: simulated, dHCP and HCP-YA against comparable traditional feature extraction and clustering techniques. Our results demonstrated the superiority of the TReND framework in the delineation of neonate FNs with significantly better spatial contiguity and functional homogeneity. Collectively, we established TReND, a novel and robust framework, for neonatal FN delineation. TReND-derived neonatal FNs could serve as a neonatal functional atlas for perinatal populations in health and disease.

Risheng Liu, Zi Li, Xin Fan et al.

Conventional deformable registration methods aim at solving an optimization model carefully designed on image pairs and their computational costs are exceptionally high. In contrast, recent deep learning based approaches can provide fast deformation estimation. These heuristic network architectures are fully data-driven and thus lack explicit geometric constraints, e.g., topology-preserving, which are indispensable to generate plausible deformations. We design a new deep learning based framework to optimize a diffeomorphic model via multi-scale propagation in order to integrate advantages and avoid limitations of these two categories of approaches. Specifically, we introduce a generic optimization model to formulate diffeomorphic registration and develop a series of learnable architectures to obtain propagative updating in the coarse-to-fine feature space. Moreover, we propose a novel bilevel self-tuned training strategy, allowing efficient search of task-specific hyper-parameters. This training strategy increases the flexibility to various types of data while reduces computational and human burdens. We conduct two groups of image registration experiments on 3D volume datasets including image-to-atlas registration on brain MRI data and image-to-image registration on liver CT data. Extensive results demonstrate the state-of-the-art performance of the proposed method with diffeomorphic guarantee and extreme efficiency. We also apply our framework to challenging multi-modal image registration, and investigate how our registration to support the down-streaming tasks for medical image analysis including multi-modal fusion and image segmentation.