Can Li

Song Wang, Zhu Wang, Can Li et al.

In comparison to conventional RGB cameras, the superior temporal resolution of event cameras allows them to capture rich information between frames, making them prime candidates for object tracking. Yet in practice, despite their theoretical advantages, the body of work on event-based multi-object tracking (MOT) remains in its infancy, especially in real-world settings where events from complex background and camera motion can easily obscure the true target motion. In this work, an event-based multi-object tracker, called SpikeMOT, is presented to address these challenges. SpikeMOT leverages spiking neural networks to extract sparse spatiotemporal features from event streams associated with objects. The resulting spike train representations are used to track the object movement at high frequency, while a simultaneous object detector provides updated spatial information of these objects at an equivalent frame rate. To evaluate the effectiveness of SpikeMOT, we introduce DSEC-MOT, the first large-scale event-based MOT benchmark incorporating fine-grained annotations for objects experiencing severe occlusions, frequent trajectory intersections, and long-term re-identification in real-world contexts. Extensive experiments employing DSEC-MOT and another event-based dataset, named FE240hz, demonstrate SpikeMOT's capability to achieve high tracking accuracy amidst challenging real-world scenarios, advancing the state-of-the-art in event-based multi-object tracking.

Can Li, Xiaoqian Jiang, Kai Zhang

Liver transplantation is a life-saving procedure for patients with end-stage liver disease. There are two main challenges in liver transplant: finding the best matching patient for a donor and ensuring transplant equity among different subpopulations. The current MELD scoring system evaluates a patient's mortality risk if not receiving an organ within 90 days. However, the donor-patient matching should also consider post-transplant risk factors, such as cardiovascular disease, chronic rejection, etc., which are all common complications after transplant. Accurate prediction of these risk scores remains a significant challenge. In this study, we used predictive models to solve the above challenges. Specifically, we proposed a deep-learning model to predict multiple risk factors after a liver transplant. By formulating it as a multi-task learning problem, the proposed deep neural network was trained to simultaneously predict the five post-transplant risks and achieve equal good performance by exploiting task-balancing techniques. We also proposed a novel fairness-achieving algorithm to ensure prediction fairness across different subpopulations. We used electronic health records of 160,360 liver transplant patients, including demographic information, clinical variables, and laboratory values, collected from the liver transplant records of the United States from 1987 to 2018. The model's performance was evaluated using various performance metrics such as AUROC and AUPRC. Our experiment results highlighted the success of our multitask model in achieving task balance while maintaining accuracy. The model significantly reduced the task discrepancy by 39%. Further application of the fairness-achieving algorithm substantially reduced fairness disparity among all sensitive attributes (gender, age group, and race/ethnicity) in each risk factor.

Can Li, Dejian Lai, Xiaoqian Jiang et al.

Liver transplantation often faces fairness challenges across subgroups defined by sensitive attributes such as age group, gender, and race/ethnicity. Machine learning models for outcome prediction can introduce additional biases. Therefore, we introduce Fairness through the Equitable Rate of Improvement in Multitask Learning (FERI) algorithm for fair predictions of graft failure risk in liver transplant patients. FERI constrains subgroup loss by balancing learning rates and preventing subgroup dominance in the training process. Our results show that FERI maintained high predictive accuracy with AUROC and AUPRC comparable to baseline models. More importantly, FERI demonstrated an ability to improve fairness without sacrificing accuracy. Specifically, for the gender, FERI reduced the demographic parity disparity by 71.74%, and for the age group, it decreased the equalized odds disparity by 40.46%. Therefore, the FERI algorithm advanced fairness-aware predictive modeling in healthcare and provides an invaluable tool for equitable healthcare systems.

Pulakesh Upadhyaya, Kai Zhang, Can Li et al.

Causal structure learning refers to a process of identifying causal structures from observational data, and it can have multiple applications in biomedicine and health care. This paper provides a practical review and tutorial on scalable causal structure learning models with examples of real-world data to help health care audiences understand and apply them. We reviewed traditional (combinatorial and score-based methods) for causal structure discovery and machine learning-based schemes. We also highlighted recent developments in biomedicine where causal structure learning can be applied to discover structures such as gene networks, brain connectivity networks, and those in cancer epidemiology. We also compared the performance of traditional and machine learning-based algorithms for causal discovery over some benchmark data sets. Machine learning-based approaches, including deep learning, have many advantages over traditional approaches, such as scalability, including a greater number of variables, and potentially being applied in a wide range of biomedical applications, such as genetics, if sufficient data are available. Furthermore, these models are more flexible than traditional models and are poised to positively affect many applications in the future.