Mehul A. Shah

Supriya Nagesh, Nina Mishra, Yonatan Naamad et al.

Machine learning models perform well on several healthcare tasks and can help reduce the burden on the healthcare system. However, the lack of explainability is a major roadblock to their adoption in hospitals. \textit{How can the decision of an ML model be explained to a physician?} The explanations considered in this paper are counterfactuals (CFs), hypothetical scenarios that would have resulted in the opposite outcome. Specifically, time-series CFs are investigated, inspired by the way physicians converse and reason out decisions `I would have given the patient a vasopressor if their blood pressure was lower and falling'. Key properties of CFs that are particularly meaningful in clinical settings are outlined: physiological plausibility, relevance to the task and sparse perturbations. Past work on CF generation does not satisfy these properties, specifically plausibility in that realistic time-series CFs are not generated. A variational autoencoder (VAE)-based approach is proposed that captures these desired properties. The method produces CFs that improve on prior approaches quantitatively (more plausible CFs as evaluated by their likelihood w.r.t original data distribution, and 100$\times$ faster at generating CFs) and qualitatively (2$\times$ more plausible and relevant) as evaluated by three physicians.

Eric Anderson, Jonathan Fritz, Austin Lee et al.

LLMs demonstrate an uncanny ability to process unstructured data, and as such, have the potential to go beyond search and run complex, semantic analyses at scale. We describe the design of an unstructured analytics system, Aryn, and the tenets and use cases that motivate its design. With Aryn, users specify queries in natural language and the system automatically determines a semantic plan and executes it to compute an answer from a large collection of unstructured documents. At the core of Aryn is Sycamore, a declarative document processing engine, that provides a reliable distributed abstraction called DocSets. Sycamore allows users to analyze, enrich, and transform complex documents at scale. Aryn includes Luna, a query planner that translates natural language queries to Sycamore scripts, and DocParse, which takes raw PDFs and document images, and converts them to DocSets for downstream processing. We show how these pieces come together to achieve better accuracy than RAG on analytics queries over real world reports from the National Transportation Safety Board (NTSB). Also, given current limitations of LLMs, we argue that an analytics system must provide explainability to be practical, and show how Aryn's user interface does this to help build trust.