Ya-Qin Zhang

Pengfei Li, Beiwen Tian, Yongliang Shi et al.

Current referring expression comprehension algorithms can effectively detect or segment objects indicated by nouns, but how to understand verb reference is still under-explored. As such, we study the challenging problem of task oriented detection, which aims to find objects that best afford an action indicated by verbs like sit comfortably on. Towards a finer localization that better serves downstream applications like robot interaction, we extend the problem into task oriented instance segmentation. A unique requirement of this task is to select preferred candidates among possible alternatives. Thus we resort to the transformer architecture which naturally models pair-wise query relationships with attention, leading to the TOIST method. In order to leverage pre-trained noun referring expression comprehension models and the fact that we can access privileged noun ground truth during training, a novel noun-pronoun distillation framework is proposed. Noun prototypes are generated in an unsupervised manner and contextual pronoun features are trained to select prototypes. As such, the network remains noun-agnostic during inference. We evaluate TOIST on the large-scale task oriented dataset COCO-Tasks and achieve +10.9% higher $\rm{mAP^{box}}$ than the best-reported results. The proposed noun-pronoun distillation can boost $\rm{mAP^{box}}$ and $\rm{mAP^{mask}}$ by +2.8% and +3.8%. Codes and models are publicly available at https://github.com/AIR-DISCOVER/TOIST.

Yoshua Bengio, Geoffrey Hinton, Andrew Yao et al. · mila

Artificial Intelligence (AI) is progressing rapidly, and companies are shifting their focus to developing generalist AI systems that can autonomously act and pursue goals. Increases in capabilities and autonomy may soon massively amplify AI's impact, with risks that include large-scale social harms, malicious uses, and an irreversible loss of human control over autonomous AI systems. Although researchers have warned of extreme risks from AI, there is a lack of consensus about how exactly such risks arise, and how to manage them. Society's response, despite promising first steps, is incommensurate with the possibility of rapid, transformative progress that is expected by many experts. AI safety research is lagging. Present governance initiatives lack the mechanisms and institutions to prevent misuse and recklessness, and barely address autonomous systems. In this short consensus paper, we describe extreme risks from upcoming, advanced AI systems. Drawing on lessons learned from other safety-critical technologies, we then outline a comprehensive plan combining technical research and development with proactive, adaptive governance mechanisms for a more commensurate preparation.

Keyue Qiu, Yixin Wu, Lihao Wang et al.

We present AMix-2, a protein-text foundation model that establishes protein as a native modality in large language models (LLMs), unifying protein understanding and sequence design within a single foundation model. AMix-2 is built upon two key ideas: (1) a unified protein-text formulation that embeds natural language and protein sequence in a shared token space, enabling one model to perform biological reasoning and conditional design instead of separate downstream task-specialized models; and (2) a block-wise diffusion language modeling backbone that combines causal generation across blocks with bidirectional context and iterative refinement within blocks. This scheme better matches the intrinsic nature of proteins than a strict left-to-right factorization. To evaluate protein foundation models under realistic generalization settings, we further introduce ProteinArena, a comprehensive benchmark with time-aware and homology-aware protocols across various understanding and design tasks, and with baselines covering classical bioinformatics tools, protein-specialized models and LLMs. On ProteinArena, AMix-2 outperforms frontier LLMs and demonstrates competitive performance to task-specific protein models. Controlled experiments further show that the diffusion-based paradigm generally surpasses its autoregressive counterpart, highlighting the advantage of flexible generation order for protein sequences. We release both AMix-2 and ProteinArena to facilitate open research in protein foundation models.

Tongda Xu, Han Gao, Chenjian Gao et al.

In this paper, we consider the problem of bit allocation in Neural Video Compression (NVC). First, we reveal a fundamental relationship between bit allocation in NVC and Semi-Amortized Variational Inference (SAVI). Specifically, we show that SAVI with GoP (Group-of-Picture)-level likelihood is equivalent to pixel-level bit allocation with precise rate \& quality dependency model. Based on this equivalence, we establish a new paradigm of bit allocation using SAVI. Different from previous bit allocation methods, our approach requires no empirical model and is thus optimal. Moreover, as the original SAVI using gradient ascent only applies to single-level latent, we extend the SAVI to multi-level such as NVC by recursively applying back-propagating through gradient ascent. Finally, we propose a tractable approximation for practical implementation. Our method can be applied to scenarios where performance outweights encoding speed, and serves as an empirical bound on the R-D performance of bit allocation. Experimental results show that current state-of-the-art bit allocation algorithms still have a room of $\approx 0.5$ dB PSNR to improve compared with ours. Code is available at \url{https://github.com/tongdaxu/Bit-Allocation-Using-Optimization}.

Pengfei Li, Ruowen Zhao, Yongliang Shi et al.

Scene completion refers to obtaining dense scene representation from an incomplete perception of complex 3D scenes. This helps robots detect multi-scale obstacles and analyse object occlusions in scenarios such as autonomous driving. Recent advances show that implicit representation learning can be leveraged for continuous scene completion and achieved through physical constraints like Eikonal equations. However, former Eikonal completion methods only demonstrate results on watertight meshes at a scale of tens of meshes. None of them are successfully done for non-watertight LiDAR point clouds of open large scenes at a scale of thousands of scenes. In this paper, we propose a novel Eikonal formulation that conditions the implicit representation on localized shape priors which function as dense boundary value constraints, and demonstrate it works on SemanticKITTI and SemanticPOSS. It can also be extended to semantic Eikonal scene completion with only small modifications to the network architecture. With extensive quantitative and qualitative results, we demonstrate the benefits and drawbacks of existing Eikonal methods, which naturally leads to the new locally conditioned formulation. Notably, we improve IoU from 31.7% to 51.2% on SemanticKITTI and from 40.5% to 48.7% on SemanticPOSS. We extensively ablate our methods and demonstrate that the proposed formulation is robust to a wide spectrum of implementation hyper-parameters. Codes and models are publicly available at https://github.com/AIR-DISCOVER/LODE.

Xiaoxue Chen, Junchen Liu, Hao Zhao et al.

Neural radiance fields (NeRF) have revolutionized the field of image-based view synthesis. However, NeRF uses straight rays and fails to deal with complicated light path changes caused by refraction and reflection. This prevents NeRF from successfully synthesizing transparent or specular objects, which are ubiquitous in real-world robotics and A/VR applications. In this paper, we introduce the refractive-reflective field. Taking the object silhouette as input, we first utilize marching tetrahedra with a progressive encoding to reconstruct the geometry of non-Lambertian objects and then model refraction and reflection effects of the object in a unified framework using Fresnel terms. Meanwhile, to achieve efficient and effective anti-aliasing, we propose a virtual cone supersampling technique. We benchmark our method on different shapes, backgrounds and Fresnel terms on both real-world and synthetic datasets. We also qualitatively and quantitatively benchmark the rendering results of various editing applications, including material editing, object replacement/insertion, and environment illumination estimation. Codes and data are publicly available at https://github.com/dawning77/NeRRF.

Yang Liu, Yan Kang, Tianyuan Zou et al.

Vertical Federated Learning (VFL) is a federated learning setting where multiple parties with different features about the same set of users jointly train machine learning models without exposing their raw data or model parameters. Motivated by the rapid growth in VFL research and real-world applications, we provide a comprehensive review of the concept and algorithms of VFL, as well as current advances and challenges in various aspects, including effectiveness, efficiency, and privacy. We provide an exhaustive categorization for VFL settings and privacy-preserving protocols and comprehensively analyze the privacy attacks and defense strategies for each protocol. In the end, we propose a unified framework, termed VFLow, which considers the VFL problem under communication, computation, privacy, as well as effectiveness and fairness constraints. Finally, we review the most recent advances in industrial applications, highlighting open challenges and future directions for VFL.

Xiaoxue Chen, Yuhang Zheng, Yupeng Zheng et al.

Nowadays, many visual scene understanding problems are addressed by dense prediction networks. But pixel-wise dense annotations are very expensive (e.g., for scene parsing) or impossible (e.g., for intrinsic image decomposition), motivating us to leverage cheap point-level weak supervision. However, existing pointly-supervised methods still use the same architecture designed for full supervision. In stark contrast to them, we propose a new paradigm that makes predictions for point coordinate queries, as inspired by the recent success of implicit representations, like distance or radiance fields. As such, the method is named as dense prediction fields (DPFs). DPFs generate expressive intermediate features for continuous sub-pixel locations, thus allowing outputs of an arbitrary resolution. DPFs are naturally compatible with point-level supervision. We showcase the effectiveness of DPFs using two substantially different tasks: high-level semantic parsing and low-level intrinsic image decomposition. In these two cases, supervision comes in the form of single-point semantic category and two-point relative reflectance, respectively. As benchmarked by three large-scale public datasets PASCALContext, ADE20K and IIW, DPFs set new state-of-the-art performance on all of them with significant margins. Code can be accessed at https://github.com/cxx226/DPF.

Jianxiong Li, Xianyuan Zhan, Haoran Xu et al. · tsinghua

In offline reinforcement learning (RL), one detrimental issue to policy learning is the error accumulation of deep Q function in out-of-distribution (OOD) areas. Unfortunately, existing offline RL methods are often over-conservative, inevitably hurting generalization performance outside data distribution. In our study, one interesting observation is that deep Q functions approximate well inside the convex hull of training data. Inspired by this, we propose a new method, DOGE (Distance-sensitive Offline RL with better GEneralization). DOGE marries dataset geometry with deep function approximators in offline RL, and enables exploitation in generalizable OOD areas rather than strictly constraining policy within data distribution. Specifically, DOGE trains a state-conditioned distance function that can be readily plugged into standard actor-critic methods as a policy constraint. Simple yet elegant, our algorithm enjoys better generalization compared to state-of-the-art methods on D4RL benchmarks. Theoretical analysis demonstrates the superiority of our approach to existing methods that are solely based on data distribution or support constraints.

Jianxiong Li, Xiao Hu, Haoran Xu et al. · tsinghua

Reward function is essential in reinforcement learning (RL), serving as the guiding signal to incentivize agents to solve given tasks, however, is also notoriously difficult to design. In many cases, only imperfect rewards are available, which inflicts substantial performance loss for RL agents. In this study, we propose a unified offline policy optimization approach, \textit{RGM (Reward Gap Minimization)}, which can smartly handle diverse types of imperfect rewards. RGM is formulated as a bi-level optimization problem: the upper layer optimizes a reward correction term that performs visitation distribution matching w.r.t. some expert data; the lower layer solves a pessimistic RL problem with the corrected rewards. By exploiting the duality of the lower layer, we derive a tractable algorithm that enables sampled-based learning without any online interactions. Comprehensive experiments demonstrate that RGM achieves superior performance to existing methods under diverse settings of imperfect rewards. Further, RGM can effectively correct wrong or inconsistent rewards against expert preference and retrieve useful information from biased rewards.

Jingliang Duan, Wenxuan Wang, Liming Xiao et al.

Reinforcement learning (RL) has shown remarkable success in solving complex decision-making and control tasks. However, many model-free RL algorithms experience performance degradation due to inaccurate value estimation, particularly the overestimation of Q-values, which can lead to suboptimal policies. To address this issue, we previously proposed the Distributional Soft Actor-Critic (DSAC or DSACv1), an off-policy RL algorithm that enhances value estimation accuracy by learning a continuous Gaussian value distribution. Despite its effectiveness, DSACv1 faces challenges such as training instability and sensitivity to reward scaling, caused by high variance in critic gradients due to return randomness. In this paper, we introduce three key refinements to DSACv1 to overcome these limitations and further improve Q-value estimation accuracy: expected value substitution, twin value distribution learning, and variance-based critic gradient adjustment. The enhanced algorithm, termed DSAC with Three refinements (DSAC-T or DSACv2), is systematically evaluated across a diverse set of benchmark tasks. Without the need for task-specific hyperparameter tuning, DSAC-T consistently matches or outperforms leading model-free RL algorithms, including SAC, TD3, DDPG, TRPO, and PPO, in all tested environments. Additionally, DSAC-T ensures a stable learning process and maintains robust performance across varying reward scales. Its effectiveness is further demonstrated through real-world application in controlling a wheeled robot, highlighting its potential for deployment in practical robotic tasks.

Tianyuan Zou, Zixuan Gu, Yu He et al.

Vertical Federated Learning (VFL) has emerged as a collaborative training paradigm that allows participants with different features of the same group of users to accomplish cooperative training without exposing their raw data or model parameters. VFL has gained significant attention for its research potential and real-world applications in recent years, but still faces substantial challenges, such as in defending various kinds of data inference and backdoor attacks. Moreover, most of existing VFL projects are industry-facing and not easily used for keeping track of the current research progress. To address this need, we present an extensible and lightweight VFL framework VFLAIR (available at https://github.com/FLAIR-THU/VFLAIR), which supports VFL training with a variety of models, datasets and protocols, along with standardized modules for comprehensive evaluations of attacks and defense strategies. We also benchmark 11 attacks and 8 defenses performance under different communication and model partition settings and draw concrete insights and recommendations on the choice of defense strategies for different practical VFL deployment scenarios.

Tongda Xu, Qian Zhang, Yanghao Li et al.

We propose conditional perceptual quality, an extension of the perceptual quality defined in \citet{blau2018perception}, by conditioning it on user defined information. Specifically, we extend the original perceptual quality $d(p_{X},p_{\hat{X}})$ to the conditional perceptual quality $d(p_{X|Y},p_{\hat{X}|Y})$, where $X$ is the original image, $\hat{X}$ is the reconstructed, $Y$ is side information defined by user and $d(.,.)$ is divergence. We show that conditional perceptual quality has similar theoretical properties as rate-distortion-perception trade-off \citep{blau2019rethinking}. Based on these theoretical results, we propose an optimal framework for conditional perceptual quality preserving compression. Experimental results show that our codec successfully maintains high perceptual quality and semantic quality at all bitrate. Besides, by providing a lowerbound of common randomness required, we settle the previous arguments on whether randomness should be incorporated into generator for (conditional) perceptual quality compression. The source code is provided in supplementary material.

Zhe Wang, Siqi Fan, Xiaoliang Huo et al.

In autonomous driving, Vehicle-Infrastructure Cooperative 3D Object Detection (VIC3D) makes use of multi-view cameras from both vehicles and traffic infrastructure, providing a global vantage point with rich semantic context of road conditions beyond a single vehicle viewpoint. Two major challenges prevail in VIC3D: 1) inherent calibration noise when fusing multi-view images, caused by time asynchrony across cameras; 2) information loss when projecting 2D features into 3D space. To address these issues, We propose a novel 3D object detection framework, Vehicles-Infrastructure Multi-view Intermediate fusion (VIMI). First, to fully exploit the holistic perspectives from both vehicles and infrastructure, we propose a Multi-scale Cross Attention (MCA) module that fuses infrastructure and vehicle features on selective multi-scales to correct the calibration noise introduced by camera asynchrony. Then, we design a Camera-aware Channel Masking (CCM) module that uses camera parameters as priors to augment the fused features. We further introduce a Feature Compression (FC) module with channel and spatial compression blocks to reduce the size of transmitted features for enhanced efficiency. Experiments show that VIMI achieves 15.61% overall AP_3D and 21.44% AP_BEV on the new VIC3D dataset, DAIR-V2X-C, significantly outperforming state-of-the-art early fusion and late fusion methods with comparable transmission cost.

Qiying Yu, Zheng Zhang, Ruofei Zhu et al. · tsinghua

Inference scaling empowers LLMs with unprecedented reasoning ability, with reinforcement learning as the core technique to elicit complex reasoning. However, key technical details of state-of-the-art reasoning LLMs are concealed (such as in OpenAI o1 blog and DeepSeek R1 technical report), thus the community still struggles to reproduce their RL training results. We propose the $\textbf{D}$ecoupled Clip and $\textbf{D}$ynamic s$\textbf{A}$mpling $\textbf{P}$olicy $\textbf{O}$ptimization ($\textbf{DAPO}$) algorithm, and fully open-source a state-of-the-art large-scale RL system that achieves 50 points on AIME 2024 using Qwen2.5-32B base model. Unlike previous works that withhold training details, we introduce four key techniques of our algorithm that make large-scale LLM RL a success. In addition, we open-source our training code, which is built on the verl framework, along with a carefully curated and processed dataset. These components of our open-source system enhance reproducibility and support future research in large-scale LLM RL.

Tongda Xu, Wendi Zheng, Jiajun He et al.

Vector quantized variational autoencoder (VQ-VAE) is a discrete auto-encoder that compresses images into discrete tokens. It is difficult to train due to discretization. In this paper, we propose a simple yet effective technique, dubbed Gaussian Quant (GQ), that converts a Gaussian VAE with certain constraint into a VQ-VAE without training. GQ generates random Gaussian noise as a codebook and finds the closest noise to the posterior mean. Theoretically, we prove that when the logarithm of the codebook size exceeds the bits-back coding rate of the Gaussian VAE, a small quantization error is guaranteed. Practically, we propose a heuristic to train Gaussian VAE for effective GQ, named target divergence constraint (TDC). Empirically, we show that GQ outperforms previous VQ-VAEs, such as VQGAN, FSQ, LFQ, and BSQ, on both UNet and ViT architectures. Furthermore, TDC also improves upon previous Gaussian VAE discretization methods, such as TokenBridge. The source code is provided in https://github.com/tongdaxu/VQ-VAE-from-Gaussian-VAE.

Hao Wen, Yuanchun Li, Zunshuai Zhang et al.

Deep learning models are increasingly deployed to edge devices for real-time applications. To ensure stable service quality across diverse edge environments, it is highly desirable to generate tailored model architectures for different conditions. However, conventional pre-deployment model generation approaches are not satisfactory due to the difficulty of handling the diversity of edge environments and the demand for edge information. In this paper, we propose to adapt the model architecture after deployment in the target environment, where the model quality can be precisely measured and private edge data can be retained. To achieve efficient and effective edge model generation, we introduce a pretraining-assisted on-cloud model elastification method and an edge-friendly on-device architecture search method. Model elastification generates a high-quality search space of model architectures with the guidance of a developer-specified oracle model. Each subnet in the space is a valid model with different environment affinity, and each device efficiently finds and maintains the most suitable subnet based on a series of edge-tailored optimizations. Extensive experiments on various edge devices demonstrate that our approach is able to achieve significantly better accuracy-latency tradeoffs (e.g. 46.74\% higher on average accuracy with a 60\% latency budget) than strong baselines with minimal overhead (13 GPU hours in the cloud and 2 minutes on the edge server).

Jiazhi Yang, Kunyang Lin, Jinwei Li et al.

Despite the sustained scaling on model capacity and data acquisition, Vision-Language-Action (VLA) models remain brittle in contact-rich and dynamic manipulation tasks, where minor execution deviations can compound into failures. While reinforcement learning (RL) offers a principled path to robustness, on-policy RL in the physical world is constrained by safety risk, hardware cost, and environment reset. To bridge this gap, we present RISE, a scalable framework of robotic reinforcement learning via imagination. At its core is a Compositional World Model that (i) predicts multi-view future via a controllable dynamics model, and (ii) evaluates imagined outcomes with a progress value model, producing informative advantages for the policy improvement. Such compositional design allows state and value to be tailored by best-suited yet distinct architectures and objectives. These components are integrated into a closed-loop self-improving pipeline that continuously generates imaginary rollouts, estimates advantages, and updates the policy in imaginary space without costly physical interaction. Across three challenging real-world tasks, RISE yields significant improvement over prior art, with more than +35% absolute performance increase in dynamic brick sorting, +45% for backpack packing, and +35% for box closing, respectively.

Tianyuan Zou, Yang Liu, Ya-Qin Zhang

Vertical Federated Learning (VFL) is widely utilized in real-world applications to enable collaborative learning while protecting data privacy and safety. However, previous works show that parties without labels (passive parties) in VFL can infer the sensitive label information owned by the party with labels (active party) or execute backdoor attacks to VFL. Meanwhile, active party can also infer sensitive feature information from passive party. All these pose new privacy and security challenges to VFL systems. We propose a new general defense method which limits the mutual information between private raw data, including both features and labels, and intermediate outputs to achieve a better trade-off between model utility and privacy. We term this defense Mutual Information Regularization Defense (MID). We theoretically and experimentally testify the effectiveness of our MID method in defending existing attacks in VFL, including label inference attacks, backdoor attacks and feature reconstruction attacks.

Xuanyu Lei, Chenliang Li, Yuning Wu et al.

Recent advances in Large Language Models(LLMs) have enabled strong performance in long-form writing, but current training paradigms remain limited: Supervised Fine-Tuning (SFT) remains constrained by data saturation and performance ceilings, while Reinforcement Learning with Verifiable Reward (RLVR), though successful in verifiable domains like math and code, cannot be directly migrated to open-ended long-form writing due to a lack of ground-truths. To further advance long-form writing, we present Writing-RL: an Adaptive Curriculum Reinforcement Learning framework to advance long-form writing capabilities beyond SFT. The framework consists of three key components: Margin-aware Data Selection strategy that prioritizes samples with high learning potential, Pairwise Comparison Reward mechanism that provides discriminative learning signals in the absence of verifiable rewards, and Dynamic Reference Scheduling approach, which plays a critical role by adaptively adjusting task difficulty based on evolving model performance. Experiments on 7B-scale writer models show that Writing-RL effectively improves long-form writing performance over strong SFT baselines. Furthermore, we observe that models trained with long-output RL generalize surprisingly well to long-input reasoning tasks, potentially offering a promising perspective for rethinking long-context training.

Yinan Zheng, Tianyi Tan, Bin Huang et al.

Diffusion models have become a popular choice for decision-making tasks in robotics, and more recently, are also being considered for solving autonomous driving tasks. However, their applications and evaluations in autonomous driving remain limited to simulation-based or laboratory settings. The full strength of diffusion models for large-scale, complex real-world settings, such as End-to-End Autonomous Driving (E2E AD), remains underexplored. In this study, we conducted a systematic and large-scale investigation to unleash the potential of the diffusion models as planners for E2E AD, based on a tremendous amount of real-vehicle data and road testing. Through comprehensive and carefully controlled studies, we identify key insights into the diffusion loss space, trajectory representation, and data scaling that significantly impact E2E planning performance. Moreover, we also provide an effective reinforcement learning post-training strategy to further enhance the safety of the learned planner. The resulting diffusion-based learning framework, Hyper Diffusion Planner} (HDP), is deployed on a real-vehicle platform and evaluated across 6 urban driving scenarios and 200 km of real-world testing, achieving a notable 10x performance improvement over the base model. Our work demonstrates that diffusion models, when properly designed and trained, can serve as effective and scalable E2E AD planners for complex, real-world autonomous driving tasks.

Yujie Yang, Zhilong Zheng, Shengbo Eben Li et al.

Safety is the priority concern when applying reinforcement learning (RL) algorithms to real-world control problems. While policy iteration provides a fundamental algorithm for standard RL, an analogous theoretical algorithm for safe RL remains absent. In this paper, we propose feasible policy iteration (FPI), the first foundational dynamic programming algorithm for safe RL. FPI alternates between policy evaluation, region identification and policy improvement. This follows actor-critic-scenery (ACS) framework where scenery refers to a feasibility function that represents a feasible region. A region-wise update rule is developed for the policy improvement step, which maximizes state-value function inside the feasible region and minimizes feasibility function outside it. With this update rule, FPI guarantees monotonic expansion of feasible region, monotonic improvement of state-value function, and geometric convergence to the optimal safe policy. Experimental results demonstrate that FPI achieves strictly zero constraint violation on low-dimensional tasks and outperforms existing methods in constraint adherence and reward performance on high-dimensional tasks.

Tongda Xu, Han Gao, Yuanyuan Wang et al.

In this paper, we investigate the problem of bit allocation in Neural Video Compression (NVC). First, we reveal that a recent bit allocation approach claimed to be optimal is, in fact, sub-optimal due to its implementation. Specifically, we find that its sub-optimality lies in the improper application of semi-amortized variational inference (SAVI) on latent with non-factorized variational posterior. Then, we show that the corrected version of SAVI on non-factorized latent requires recursively applying back-propagating through gradient ascent, based on which we derive the corrected optimal bit allocation algorithm. Due to the computational in-feasibility of the corrected bit allocation, we design an efficient approximation to make it practical. Empirical results show that our proposed correction significantly improves the incorrect bit allocation in terms of R-D performance and bitrate error, and outperforms all other bit allocation methods by a large margin. The source code is provided in the supplementary material.

Xiang Li, Yupeng Zheng, Pengfei Li et al.

Occupancy prediction provides critical geometric and semantic understanding for robotics but faces efficiency-accuracy trade-offs. Current dense methods suffer computational waste on empty voxels, while sparse query-based approaches lack robustness in diverse and complex indoor scenes. In this paper, we propose DiScene, a novel sparse query-based framework that leverages multi-level distillation to achieve efficient and robust occupancy prediction. In particular, our method incorporates two key innovations: (1) a Multi-level Consistent Knowledge Distillation strategy, which transfers hierarchical representations from large teacher models to lightweight students through coordinated alignment across four levels, including encoder-level feature alignment, query-level feature matching, prior-level spatial guidance, and anchor-level high-confidence knowledge transfer and (2) a Teacher-Guided Initialization policy, employing optimized parameter warm-up to accelerate model convergence. Validated on the Occ-Scannet benchmark, DiScene achieves 23.2 FPS without depth priors while outperforming our baseline method, OPUS, by 36.1% and even better than the depth-enhanced version, OPUS†. With depth integration, DiScene† attains new SOTA performance, surpassing EmbodiedOcc by 3.7% with 1.62$\times$ faster inference speed. Furthermore, experiments on the Occ3D-nuScenes benchmark and in-the-wild scenarios demonstrate the versatility of our approach in various environments. Code and models can be accessed at https://github.com/getterupper/DiScene.

Tongda Xu, Mingwei He, Shady Abu-Hussein et al.

It is well known that the reconstruction FID (rFID) of a VAE is poorly correlated with the generation FID (gFID) of a latent diffusion model. We propose interpolated FID (iFID), a simple variant of rFID that exhibits a strong correlation with gFID. Specifically, for each dataset element, we retrieve its nearest neighbor in latent space, interpolate between their latent representations, decode the interpolated latent, and compute the FID between the decoded samples and the original dataset. We provide an intuitive explanation for why iFID correlates well with gFID, and why reconstruction metrics can be negatively correlated with gFID, by connecting iFID to recent results on diffusion generalization and hallucination. Theoretically, we show that iFID evaluates decoded interpolations aligned with the ridge set around which diffusion samples concentrate, thereby measuring a quantity closely related to diffusion sample quality. Empirically, iFID is the first metric shown to strongly correlate with diffusion gFID across diverse VAEs, achieving Pearson and Spearman correlations of approximately $0.85$. The project page is available at https://tongdaxu.github.io/pages/ifid.html.

Jinliang Zheng, Jianxiong Li, Dongxiu Liu et al. · tsinghua

Training on diverse, internet-scale data is a key factor in the success of recent large foundation models. Yet, using the same recipe for building embodied agents has faced noticeable difficulties. Despite the availability of many crowd-sourced embodied datasets, their action spaces often exhibit significant heterogeneity due to distinct physical embodiment and control interfaces for different robots, causing substantial challenges in developing embodied foundation models using cross-domain data. In this paper, we introduce UniAct, a new embodied foundation modeling framework operating in a Universal Action Space. Our learned universal actions capture the generic atomic behaviors across diverse robots by exploiting their shared structural features, and enable enhanced cross-domain data utilization and cross-embodiment generalizations by eliminating the notorious heterogeneity. The universal actions can be efficiently translated back to heterogeneous actionable commands by simply adding embodiment-specific details, from which fast adaptation to new robots becomes simple and straightforward. Our 0.5B instantiation of UniAct outperforms 14X larger SOTA embodied foundation models in extensive evaluations on various real-world and simulation robots, showcasing exceptional cross-embodiment control and adaptation capability, highlighting the crucial benefit of adopting universal actions. Project page: https://github.com/2toinf/UniAct

Tongda Xu, Ziran Zhu, Dailan He et al.

Idempotence is the stability of image codec to re-compression. At the first glance, it is unrelated to perceptual image compression. However, we find that theoretically: 1) Conditional generative model-based perceptual codec satisfies idempotence; 2) Unconditional generative model with idempotence constraint is equivalent to conditional generative codec. Based on this newfound equivalence, we propose a new paradigm of perceptual image codec by inverting unconditional generative model with idempotence constraints. Our codec is theoretically equivalent to conditional generative codec, and it does not require training new models. Instead, it only requires a pre-trained mean-square-error codec and unconditional generative model. Empirically, we show that our proposed approach outperforms state-of-the-art methods such as HiFiC and ILLM, in terms of Fréchet Inception Distance (FID). The source code is provided in https://github.com/tongdaxu/Idempotence-and-Perceptual-Image-Compression.

Binghan Wu, Shoufeng Wang, Yunxin Liu et al.

Realizing Level 4/5 Autonomous Networks (AN) demands a shift from static automation to agent-native intelligence. Current operations, reliant on rigid scripts, lack the cognitive agency to handle off-nominal conditions. To address this, this letter proposes a hierarchical multi-agent reference architecture enabling high-level autonomy. The framework features a Dual-Driven Orchestrator that coordinates specialized Executive Agents, supported by a shared Public Memory for unified domain knowledge. A key innovation is the integration of agent self-awareness, which empowers the system to harmonize deliberative strategic governance with reflexive fault recovery. We instantiate and validate this architecture within a 5G Core environment. Case studies demonstrate that the system sustains critical throughput under congestion and reduces Mean Time to Repair (MTTR) by 86%, confirming its efficacy in unifying strategic planning with operational resilience.

Hao Wen, Shizuo Tian, Borislav Pavlov et al.

Large language models (LLMs) have brought exciting new advances to mobile UI agents, a long-standing research field that aims to complete arbitrary natural language tasks through mobile UI interactions. However, existing UI agents usually demand powerful large language models that are difficult to be deployed locally on end-users' devices, raising huge concerns about user privacy and centralized serving cost. Inspired by the remarkable coding abilities of recent small language models (SLMs), we propose to convert the UI task automation problem to a code generation problem, which can be effectively solved by an on-device SLM and efficiently executed with an on-device code interpreter. Unlike normal coding tasks that can be extensively pre-trained with public datasets, generating UI automation code is challenging due to the diversity, complexity, and variability of target apps. Therefore, we adopt a document-centered approach that automatically builds fine-grained API documentation for each app and generates diverse task samples based on this documentation. By guiding the agent with the synthetic documents and task samples, it learns to generate precise and efficient scripts to complete unseen tasks. Based on detailed comparisons with state-of-the-art mobile UI agents, our approach effectively improves the mobile task automation with significantly higher success rates and lower latency/token consumption. Code is open-sourced at https://github.com/MobileLLM/AutoDroid-V2.

Tongda Xu, Xiyan Cai, Xinjie Zhang et al.

Recent advancements in diffusion models have been leveraged to address inverse problems without additional training, and Diffusion Posterior Sampling (DPS) (Chung et al., 2022a) is among the most popular approaches. Previous analyses suggest that DPS accomplishes posterior sampling by approximating the conditional score. While in this paper, we demonstrate that the conditional score approximation employed by DPS is not as effective as previously assumed, but rather aligns more closely with the principle of maximizing a posterior (MAP). This assertion is substantiated through an examination of DPS on 512x512 ImageNet images, revealing that: 1) DPS's conditional score estimation significantly diverges from the score of a well-trained conditional diffusion model and is even inferior to the unconditional score; 2) The mean of DPS's conditional score estimation deviates significantly from zero, rendering it an invalid score estimation; 3) DPS generates high-quality samples with significantly lower diversity. In light of the above findings, we posit that DPS more closely resembles MAP than a conditional score estimator, and accordingly propose the following enhancements to DPS: 1) we explicitly maximize the posterior through multi-step gradient ascent and projection; 2) we utilize a light-weighted conditional score estimator trained with only 100 images and 8 GPU hours. Extensive experimental results indicate that these proposed improvements significantly enhance DPS's performance. The source code for these improvements is provided in https://github.com/tongdaxu/Rethinking-Diffusion-Posterior-Sampling-From-Conditional-Score-Estimator-to-Maximizing-a-Posterior.

Tianyuan Zou, Yang Liu, Peng Li et al. · tsinghua

Substantial quantity and high quality are the golden rules of making a good training dataset with sample privacy protection equally important. Generating synthetic samples that resemble high-quality private data while ensuring Differential Privacy (DP), a formal privacy guarantee, promises scalability and practicality. However, existing methods relying on pre-trained models for data synthesis %that avoid fine-tuning large pre-trained generative models often struggle in data-deficient scenarios, suffering from limited sample size, inevitable generation noise and existing pre-trained model bias. To address these challenges, we propose a novel contrAstive private data Synthesis via Weighted multiple Pre-trained language models (PLM) framework, named as WASP. WASP utilizes limited private samples for more accurate private data distribution estimation via a Top-Q voting mechanism, and leverages low-quality synthetic samples for contrastive generation via collaboration among dynamically weighted multiple pre-trained models.Extensive experiments on 6 well-developed datasets with 6 open-source and 3 closed-source PLMs demonstrate the superiority of WASP in improving model performance over diverse downstream tasks. Code is available at https://anonymous.4open.science/r/WASP.

Bowei He, Bowen Gao, Yankai Chen et al.

Virtual screening (VS) is an essential task in drug discovery, focusing on the identification of small-molecule ligands that bind to specific protein pockets. Existing deep learning methods, from early regression models to recent contrastive learning approaches, primarily rely on structural data while overlooking protein sequences, which are more accessible and can enhance generalizability. However, directly integrating protein sequences poses challenges due to the redundancy and noise in large-scale protein-ligand datasets. To address these limitations, we propose \textbf{S$^2$Drug}, a two-stage framework that explicitly incorporates protein \textbf{S}equence information and 3D \textbf{S}tructure context in protein-ligand contrastive representation learning. In the first stage, we perform protein sequence pretraining on ChemBL using an ESM2-based backbone, combined with a tailored data sampling strategy to reduce redundancy and noise on both protein and ligand sides. In the second stage, we fine-tune on PDBBind by fusing sequence and structure information through a residue-level gating module, while introducing an auxiliary binding site prediction task. This auxiliary task guides the model to accurately localize binding residues within the protein sequence and capture their 3D spatial arrangement, thereby refining protein-ligand matching. Across multiple benchmarks, S$^2$Drug consistently improves virtual screening performance and achieves strong results on binding site prediction, demonstrating the value of bridging sequence and structure in contrastive learning.

Zhicheng Cai, Xinyuan Guo, Yu Pei et al.

Autonomous agents driven by Large Language Models (LLMs) have revolutionized reasoning and problem-solving but remain static after training, unable to grow with experience as intelligent beings do during deployment. We introduce Forward Learning with EXperience (FLEX), a gradient-free learning paradigm that enables LLM agents to continuously evolve through accumulated experience. Specifically, FLEX cultivates scalable and inheritable evolution by constructing a structured experience library through continual reflection on successes and failures during interaction with the environment. FLEX delivers substantial improvements on mathematical reasoning, chemical retrosynthesis, and protein fitness prediction (up to 23% on AIME25, 10% on USPTO50k, and 14% on ProteinGym). We further identify a clear scaling law of experiential growth and the phenomenon of experience inheritance across agents, marking a step toward scalable and inheritable continuous agent evolution. Project Page: https://flex-gensi-thuair.github.io.

Xiaoxue Chen, Ziyi Xiong, Yuantao Chen et al.

Autonomous driving needs fast, scalable 4D reconstruction and re-simulation for training and evaluation, yet most methods for dynamic driving scenes still rely on per-scene optimization, known camera calibration, or short frame windows, making them slow and impractical. We revisit this problem from a feedforward perspective and introduce \textbf{Driving Gaussian Grounded Transformer (DGGT)}, a unified framework for pose-free dynamic scene reconstruction. We note that the existing formulations, treating camera pose as a required input, limit flexibility and scalability. Instead, we reformulate pose as an output of the model, enabling reconstruction directly from sparse, unposed images and supporting an arbitrary number of views for long sequences. Our approach jointly predicts per-frame 3D Gaussian maps and camera parameters, disentangles dynamics with a lightweight dynamic head, and preserves temporal consistency with a lifespan head that modulates visibility over time. A diffusion-based rendering refinement further reduces motion/interpolation artifacts and improves novel-view quality under sparse inputs. The result is a single-pass, pose-free algorithm that achieves state-of-the-art performance and speed. Trained and evaluated on large-scale driving benchmarks (Waymo, nuScenes, Argoverse2), our method outperforms prior work both when trained on each dataset and in zero-shot transfer across datasets, and it scales well as the number of input frames increases.

Yuanchun Li, Hao Wen, Weijun Wang et al. · tsinghua

Since the advent of personal computing devices, intelligent personal assistants (IPAs) have been one of the key technologies that researchers and engineers have focused on, aiming to help users efficiently obtain information and execute tasks, and provide users with more intelligent, convenient, and rich interaction experiences. With the development of smartphones and IoT, computing and sensing devices have become ubiquitous, greatly expanding the boundaries of IPAs. However, due to the lack of capabilities such as user intent understanding, task planning, tool using, and personal data management etc., existing IPAs still have limited practicality and scalability. Recently, the emergence of foundation models, represented by large language models (LLMs), brings new opportunities for the development of IPAs. With the powerful semantic understanding and reasoning capabilities, LLM can enable intelligent agents to solve complex problems autonomously. In this paper, we focus on Personal LLM Agents, which are LLM-based agents that are deeply integrated with personal data and personal devices and used for personal assistance. We envision that Personal LLM Agents will become a major software paradigm for end-users in the upcoming era. To realize this vision, we take the first step to discuss several important questions about Personal LLM Agents, including their architecture, capability, efficiency and security. We start by summarizing the key components and design choices in the architecture of Personal LLM Agents, followed by an in-depth analysis of the opinions collected from domain experts. Next, we discuss several key challenges to achieve intelligent, efficient and secure Personal LLM Agents, followed by a comprehensive survey of representative solutions to address these challenges.

Junkai Li, Yunghwei Lai, Weitao Li et al.

The recent rapid development of large language models (LLMs) has sparked a new wave of technological revolution in medical artificial intelligence (AI). While LLMs are designed to understand and generate text like a human, autonomous agents that utilize LLMs as their "brain" have exhibited capabilities beyond text processing such as planning, reflection, and using tools by enabling their "bodies" to interact with the environment. We introduce a simulacrum of hospital called Agent Hospital that simulates the entire process of treating illness, in which all patients, nurses, and doctors are LLM-powered autonomous agents. Within the simulacrum, doctor agents are able to evolve by treating a large number of patient agents without the need to label training data manually. After treating tens of thousands of patient agents in the simulacrum (human doctors may take several years in the real world), the evolved doctor agents outperform state-of-the-art medical agent methods on the MedQA benchmark comprising US Medical Licensing Examination (USMLE) test questions. Our methods of simulacrum construction and agent evolution have the potential in benefiting a broad range of applications beyond medical AI.

Tianyuan Zou, Liang Yue, Yang Liu et al.

With the growing prevalence of always-on hardware such as smart glasses, body cameras, and home security systems, life-logging visual sensing is becoming inevitable, forming the backbone of persistent, always-on AI systems. Meanwhile, recent advances in proactive agents and world models signal a fundamental shift from episodic, prompt-driven tools to next-generation AI systems that continuously perceive and react to the physical world. Although life-logging video streams can substantially improve utility of these promising systems, they also introduce significant privacy risks by revealing sensitive information, such as behavioral patterns, emotional states, and social interactions, beyond what isolated images expose. If unresolved, these risks may undermine public trust and hinder the sustainable development of always-on AI technologies. Existing privacy protections are either attack-specific or incur substantial utility loss, and fail to consider the entire data exploitation pipeline. We therefore posit that the privacy-utility trade-off in life-logging video streams is a foundational challenge for next-generation AI systems that demands further investigation. We call for novel pipeline-aware privacy-preserving designs that jointly optimize utility and privacy for long-horizon life-logging visual data. In parallel, formal privacy leakage metrics and standardized benchmarks remain important open directions for future research.

Tianyuan Zou, Yang Liu, Peng Li et al.

Data generation-based zero-shot learning, although effective in training Small Task-specific Models (STMs) via synthetic datasets generated by Pre-trained Language Models (PLMs), is often limited by the low quality of such synthetic datasets. Previous solutions have primarily focused on single PLM settings, where synthetic datasets are typically restricted to specific sub-spaces and often deviate from real-world distributions, leading to severe distribution bias. To mitigate such bias, we propose FuseGen, a novel data generation-based zero-shot learning framework that introduces a new criteria for subset selection from synthetic datasets via utilizing multiple PLMs and trained STMs. The chosen subset provides in-context feedback to each PLM, enhancing dataset quality through iterative data generation. Trained STMs are then used for sample re-weighting as well, further improving data quality. Extensive experiments across diverse tasks demonstrate that FuseGen substantially outperforms existing methods, highly effective in boosting STM performance in a PLM-agnostic way. Code is provided in https://github.com/LindaLydia/FuseGen.

Pengfei Li, Yongliang Shi, Tianyu Liu et al.

Recent advances show that semi-supervised implicit representation learning can be achieved through physical constraints like Eikonal equations. However, this scheme has not yet been successfully used for LiDAR point cloud data, due to its spatially varying sparsity. In this paper, we develop a novel formulation that conditions the semi-supervised implicit function on localized shape embeddings. It exploits the strong representation learning power of sparse convolutional networks to generate shape-aware dense feature volumes, while still allows semi-supervised signed distance function learning without knowing its exact values at free space. With extensive quantitative and qualitative results, we demonstrate intrinsic properties of this new learning system and its usefulness in real-world road scenes. Notably, we improve IoU from 26.3% to 51.0% on SemanticKITTI. Moreover, we explore two paradigms to integrate semantic label predictions, achieving implicit semantic completion. Code and models can be accessed at https://github.com/OPEN-AIR-SUN/SISC.

Xiaoxue Chen, Tianyu Liu, Hao Zhao et al.

Multi-task indoor scene understanding is widely considered as an intriguing formulation, as the affinity of different tasks may lead to improved performance. In this paper, we tackle the new problem of joint semantic, affordance and attribute parsing. However, successfully resolving it requires a model to capture long-range dependency, learn from weakly aligned data and properly balance sub-tasks during training. To this end, we propose an attention-based architecture named Cerberus and a tailored training framework. Our method effectively addresses the aforementioned challenges and achieves state-of-the-art performance on all three tasks. Moreover, an in-depth analysis shows concept affinity consistent with human cognition, which inspires us to explore the possibility of weakly supervised learning. Surprisingly, Cerberus achieves strong results using only 0.1%-1% annotation. Visualizations further confirm that this success is credited to common attention maps across tasks. Code and models can be accessed at https://github.com/OPEN-AIR-SUN/Cerberus.

Yuxuan Song, Zheng Zhang, Cheng Luo et al.

We present Seed Diffusion Preview, a large-scale language model based on discrete-state diffusion, offering remarkably fast inference speed. Thanks to non-sequential, parallel generation, discrete diffusion models provide a notable speedup to mitigate the inherent latency of token-by-token decoding, as demonstrated recently (e.g., Mercury Coder, Gemini Diffusion). Seed Diffusion Preview achieves an inference speed of 2,146 token/s over H20 GPUs while maintaining competitive performance across a sweep of standard code evaluation benchmarks, significantly faster than contemporary Mercury and Gemini Diffusion, establishing new state of the art on the speed-quality Pareto frontier for code models.

Yoshua Bengio, Sören Mindermann, Daniel Privitera et al. · eth-zurich, mit

The first International AI Safety Report comprehensively synthesizes the current evidence on the capabilities, risks, and safety of advanced AI systems. The report was mandated by the nations attending the AI Safety Summit in Bletchley, UK. Thirty nations, the UN, the OECD, and the EU each nominated a representative to the report's Expert Advisory Panel. A total of 100 AI experts contributed, representing diverse perspectives and disciplines. Led by the report's Chair, these independent experts collectively had full discretion over the report's content.

Yoshua Bengio, Sören Mindermann, Daniel Privitera et al. · eth-zurich

This is the interim publication of the first International Scientific Report on the Safety of Advanced AI. The report synthesises the scientific understanding of general-purpose AI -- AI that can perform a wide variety of tasks -- with a focus on understanding and managing its risks. A diverse group of 75 AI experts contributed to this report, including an international Expert Advisory Panel nominated by 30 countries, the EU, and the UN. Led by the Chair, these independent experts collectively had full discretion over the report's content. The final report is available at arXiv:2501.17805

Hongli Yu, Tinghong Chen, Jiangtao Feng et al.

Despite improvements by length extrapolation, efficient attention and memory modules, handling infinitely long documents with linear complexity without performance degradation during extrapolation remains the ultimate challenge in long-text processing. We directly optimize for long-text tasks in an end-to-end fashion and introduce a novel agent workflow, MemAgent, which reads text in segments and updates the memory using an overwrite strategy. We extend the DAPO algorithm to facilitate training via independent-context multi-conversation generation. MemAgent has demonstrated superb long-context capabilities, being able to extrapolate from an 8K context trained on 32K text to a 3.5M QA task with performance loss < 5% and achieves 95%+ in 512K RULER test.

Jianxiong Li, Jinliang Zheng, Yinan Zheng et al. · tsinghua

Multimodal pretraining is an effective strategy for the trinity of goals of representation learning in autonomous robots: 1) extracting both local and global task progressions; 2) enforcing temporal consistency of visual representation; 3) capturing trajectory-level language grounding. Most existing methods approach these via separate objectives, which often reach sub-optimal solutions. In this paper, we propose a universal unified objective that can simultaneously extract meaningful task progression information from image sequences and seamlessly align them with language instructions. We discover that via implicit preferences, where a visual trajectory inherently aligns better with its corresponding language instruction than mismatched pairs, the popular Bradley-Terry model can transform into representation learning through proper reward reparameterizations. The resulted framework, DecisionNCE, mirrors an InfoNCE-style objective but is distinctively tailored for decision-making tasks, providing an embodied representation learning framework that elegantly extracts both local and global task progression features, with temporal consistency enforced through implicit time contrastive learning, while ensuring trajectory-level instruction grounding via multimodal joint encoding. Evaluation on both simulated and real robots demonstrates that DecisionNCE effectively facilitates diverse downstream policy learning tasks, offering a versatile solution for unified representation and reward learning. Project Page: https://2toinf.github.io/DecisionNCE/

Haozhi Han, Ruge Zhang, Haoquan Chen et al.

Lifetime prediction of reactor pressure vessel (RPV) steel requires bridging atomistic degradation mechanisms with service-scale spatial and temporal regimes, from Angstroms and picoseconds to meters and decades. Existing engineering-scale models provide long-range reach but rely on fitted degradation laws, while recent atomistic kinetic Monte Carlo (AKMC) advances still fail to achieve year-and-meter-scale coverage. We present AtomWorld, an atomistic world-modeling framework for RPV steel lifetime simulation co-designed with leadership-scale supercomputing through three tightly coupled layers: (1) algorithm: AtomWorld recasts classical AKMC as an atomistic world model that learns consequence-aware state transitions over the ab initio energy landscape; (2) HPC: it co-designs this formulation with modern supercomputers, yielding a compute-dense, synchronization-light, and communication-efficient execution pipeline; and (3) application: it extends atomistic world modeling to engineering-scale simulation through a physically grounded voxel-parallel framework, offering a scalable pathway from local atomistic dynamics to engineering-scale degradation evolution. We demonstrate a paradigm shift in atomistic simulation: AtomWorld enables atomistic simulation of RPV steel across year-and-meter scales for the first time, extending direct atomistic modeling to ten-quintillion-atom systems and achieving a time-to-solution of 1.71 days for one simulated service year. These capabilities are sustained across five leadership supercomputers with 92-97% scaling efficiency and peak performance up to 1.27 EFLOP/s, corresponding to 48% of the Lineshine peak FP64 performance.

Zhe Wang, Siqi Fan, Xiaoliang Huo et al.

In autonomous driving, cooperative perception makes use of multi-view cameras from both vehicles and infrastructure, providing a global vantage point with rich semantic context of road conditions beyond a single vehicle viewpoint. Currently, two major challenges persist in vehicle-infrastructure cooperative 3D (VIC3D) object detection: $1)$ inherent pose errors when fusing multi-view images, caused by time asynchrony across cameras; $2)$ information loss in transmission process resulted from limited communication bandwidth. To address these issues, we propose a novel camera-based 3D detection framework for VIC3D task, Enhanced Multi-scale Image Feature Fusion (EMIFF). To fully exploit holistic perspectives from both vehicles and infrastructure, we propose Multi-scale Cross Attention (MCA) and Camera-aware Channel Masking (CCM) modules to enhance infrastructure and vehicle features at scale, spatial, and channel levels to correct the pose error introduced by camera asynchrony. We also introduce a Feature Compression (FC) module with channel and spatial compression blocks for transmission efficiency. Experiments show that EMIFF achieves SOTA on DAIR-V2X-C datasets, significantly outperforming previous early-fusion and late-fusion methods with comparable transmission costs.

Bowen Gao, Yanwen Huang, Yiqiao Liu et al.

The discovery of novel small molecule drugs remains a critical scientific challenge with far-reaching implications for treating diseases and advancing human health. Traditional drug development--especially for small molecule therapeutics--is a highly complex, resource-intensive, and time-consuming process that requires multidisciplinary collaboration. Recent breakthroughs in artificial intelligence (AI), particularly the rise of large language models (LLMs), present a transformative opportunity to streamline and accelerate this process. In this paper, we introduce PharmAgents, a virtual pharmaceutical ecosystem driven by LLM-based multi-agent collaboration. PharmAgents simulates the full drug discovery workflow--from target discovery to preclinical evaluation--by integrating explainable, LLM-driven agents equipped with specialized machine learning models and computational tools. Through structured knowledge exchange and automated optimization, PharmAgents identifies potential therapeutic targets, discovers promising lead compounds, enhances binding affinity and key molecular properties, and performs in silico analyses of toxicity and synthetic feasibility. Additionally, the system supports interpretability, agent interaction, and self-evolvement, enabling it to refine future drug designs based on prior experience. By showcasing the potential of LLM-powered multi-agent systems in drug discovery, this work establishes a new paradigm for autonomous, explainable, and scalable pharmaceutical research, with future extensions toward comprehensive drug lifecycle management.

Hao Wen, Yifan Su, Feifei Zhang et al.

Recent advances in Large Language Models (LLMs) have been driven by test-time compute scaling - a strategy that improves reasoning by generating longer, sequential thought processes. While effective, this approach encounters a significant bottleneck as computation increases, where further computation offers only marginal performance gains. We argue this ceiling is not an inherent limit of the model's capability but a flaw in the scaling strategy itself, a phenomenon we term "Tunnel Vision", where a model's imperfect initial steps lock it into a suboptimal reasoning path. To overcome this, we introduce a new scaling paradigm: native thought parallelism. We present ParaThinker, an end-to-end framework that trains an LLM to generate multiple, diverse reasoning paths in parallel and synthesize them into a superior final answer. By exploring different lines of thoughts simultaneously, ParaThinker effectively sidesteps the Tunnel Vision issue and unlocks the model's latent reasoning potential. Our approach demonstrates that scaling compute in parallel (width) is a more effective and efficient way to superior reasoning than simply scaling sequentially (depth). On challenging reasoning benchmarks, ParaThinker achieves substantial accuracy improvements over sequential LLMs (12.3% for 1.5B and 7.5% for 7B models on average with 8 parallel paths), while adding only negligible latency overhead (7.1%). This enables smaller models to surpass much larger counterparts and establishes parallel thinking as a critical, efficient dimension for scaling future LLMs.

Tongda Xu, Ziran Zhu, Jian Li et al.

Diffusion Inverse Solvers (DIS) are designed to sample from the conditional distribution $p_θ(X_0|y)$, with a predefined diffusion model $p_θ(X_0)$, an operator $f(\cdot)$, and a measurement $y=f(x'_0)$ derived from an unknown image $x'_0$. Existing DIS estimate the conditional score function by evaluating $f(\cdot)$ with an approximated posterior sample drawn from $p_θ(X_0|X_t)$. However, most prior approximations rely on the posterior means, which may not lie in the support of the image distribution, thereby potentially diverge from the appearance of genuine images. Such out-of-support samples may significantly degrade the performance of the operator $f(\cdot)$, particularly when it is a neural network. In this paper, we introduces a novel approach for posterior approximation that guarantees to generate valid samples within the support of the image distribution, and also enhances the compatibility with neural network-based operators $f(\cdot)$. We first demonstrate that the solution of the Probability Flow Ordinary Differential Equation (PF-ODE) with an initial value $x_t$ yields an effective posterior sample $p_θ(X_0|X_t=x_t)$. Based on this observation, we adopt the Consistency Model (CM), which is distilled from PF-ODE, for posterior sampling. Furthermore, we design a novel family of DIS using only CM. Through extensive experiments, we show that our proposed method for posterior sample approximation substantially enhance the effectiveness of DIS for neural network operators $f(\cdot)$ (e.g., in semantic segmentation). Additionally, our experiments demonstrate the effectiveness of the new CM-based inversion techniques. The source code is provided in the supplementary material.