Subhankar Chattoraj

Arunkumar Govindarajan, Arjun Agarwal, Subhankar Chattoraj et al.

Head Non-contrast computed tomography (NCCT) scan remain the preferred primary imaging modality due to their widespread availability and speed. However, the current standard for manual annotations of abnormal brain tissue on head NCCT scans involves significant disadvantages like lack of cutoff standardization and degeneration identification. The recent advancement of deep learning-based computer-aided diagnostic (CAD) models in the multidisciplinary domain has created vast opportunities in neurological medical imaging. Significant literature has been published earlier in the automated identification of brain tissue on different imaging modalities. However, determining Intracranial hemorrhage (ICH) and infarct can be challenging due to image texture, volume size, and scan quality variability. This retrospective validation study evaluated a DL-based algorithm identifying ICH and infarct from head-NCCT scans. The head-NCCT scans dataset was collected consecutively from multiple diagnostic imaging centers across India. The study exhibits the potential and limitations of such DL-based software for introduction in routine workflow in extensive healthcare facilities.

Subhankar Chattoraj, Bhargava Reddy, Manoj Tadepalli et al.

Purpose:Chest X-ray (CXR) is an essential tool and one of the most prescribed imaging to detect pulmonary abnormalities, with a yearly estimate of over 2 billion imaging performed worldwide. However, the accurate and timely diagnosis of TB remains an unmet goal. The prevalence of TB is highest in low-middle-income countries, and the requirement of a portable, automated, and reliable solution is required. In this study, we compared the performance of DL-based devices on digital and analog CXR. The evaluated DL-based device can be used in resource-constraint settings. Methods: A total of 10,000 CXR DICOMs(.dcm) and printed photos of the films acquired with three different cellular phones - Samsung S8, iPhone 8, and iPhone XS along with their radiological report were retrospectively collected from various sites across India from April 2020 to March 2021. Results: 10,000 chest X-rays were utilized to evaluate the DL-based device in identifying radiological signs of TB. The AUC of qXR for detecting signs of tuberculosis on the original DICOMs dataset was 0.928 with a sensitivity of 0.841 at a specificity of 0.806. At an optimal threshold, the difference in the AUC of three cellular smartphones with the original DICOMs is 0.024 (2.55%), 0.048 (5.10%), and 0.038 (1.91%). The minimum difference demonstrates the robustness of the DL-based device in identifying radiological signs of TB in both digital and analog CXR.

Sawon Pratiher, Subhankar Chattoraj, Rajdeep Mukherjee

A novel non-stationarity visualization tool known as StationPlot is developed for deciphering the chaotic behavior of a dynamical time series. A family of analytic measures enumerating geometrical aspects of the non-stationarity & degree of variability is formulated by convex hull geometry (CHG) on StationPlot. In the Euclidean space, both trend-stationary (TS) & difference-stationary (DS) perturbations are comprehended by the asymmetric structure of StationPlot's region of interest (ROI). The proposed method is experimentally validated using EEG signals, where it comprehend the relative temporal evolution of neural dynamics & its non-stationary morphology, thereby exemplifying its diagnostic competence for seizure activity (SA) detection. Experimental results & analysis-of-Variance (ANOVA) on the extracted CHG features demonstrates better classification performances as compared to the existing shallow feature based state-of-the-art & validates its efficacy as geometry-rich discriminative descriptors for signal processing applications.

Sawon Pratiher, Subhankar Chattoraj

Histopathological images (HI) encrypt resolution dependent heterogeneous textures & diverse color distribution variability, manifesting in micro-structural surface tissue convolutions. Also, inherently high coherency of cancerous cells poses significant challenges to breast cancer (BC) multi-classification. As such, multi-class stratification is sparsely explored & prior work mainly focus on benign & malignant tissue characterization only, which forestalls further quantitative analysis of subordinate classes like adenosis, mucinous carcinoma & fibroadenoma etc, for diagnostic competence. In this work, a fully-automated, near-real-time & computationally inexpensive robust multi-classification deep framework from HI is presented. The proposed scheme employs deep neural network (DNN) aided discriminative ensemble of holistic class-specific manifold learning (CSML) for underlying HI sub-space embedding & HI hashing based local shallow signatures. The model achieves 95.8% accuracy pertinent to multi-classification & 2.8% overall performance improvement & 38.2% enhancement for Lobular carcinoma (LC) sub-class recognition rate as compared to the existing state-of-the-art on well known BreakHis dataset is achieved. Also, 99.3% recognition rate at 200X & a sensitivity of 100% for binary grading at all magnification validates its suitability for clinical deployment in hand-held smart devices.

Subhankar Chattoraj, Karan Vishwakarma

In this paper we present a novel method for an automated diagnosis of breast carcinoma through multilevel iterative variational mode decomposition (VMD) and textural features encompassing Zernaike moments, fractal dimension and entropy features namely, Kapoor entropy, Renyi entropy, Yager entropy features are extracted from VMD components. The proposed method considers the histopathological image as a set of multidimensional spatially-evolving signals. ReliefF algorithm is used to select the discriminatory features and statistically most significant features are fed to squares support vector machine (SVM) for classification. We evaluate the efficiency of the proposed methodology on publicly available Breakhis dataset containing 7,909 breast cancer histological images, collected from 82 patients, of both benign and malignant cases. Experimental results shows the efficacy of the proposed method in outperforming the state of the art while achieving an average classification rates of 89.61% and 88:23% using three-fold and ten-fold cross-validation strategies, respectively. This system can aid the pathologist in accurate and reliable diagnosis of biopsy samples. BreaKHis, a publicly dataset available at http://web.inf.ufpr.br/vri/breast-cancer-database.