Sixian Shen

Minzhang Li, Kuixiang Shao, Xuebing Li et al.

Automated 3D scene generation is pivotal for applications spanning virtual reality, digital content creation, and Embodied AI. While computer graphics prioritizes aesthetic layouts, vision and robotics demand scenes that mirror real-world complexity which current data-driven methods struggle to achieve due to limited unstructured training data and insufficient spatial and physical modeling. We propose SPREAD, a diffusion-based framework that jointly learns spatial and physical relationships through a graph transformer, explicitly conditioning on posed scene point clouds for geometric awareness. Moreover, our model integrates differentiable guidance for collision avoidance, relational constraint, and gravity, ensuring physically coherent scenes without sacrificing relational context. Our experiments on 3D-FRONT and ProcTHOR datasets demonstrate state-of-the-art performance in spatial-relational reasoning and physical metrics. Moreover, \ours{} outperforms baselines in scene consistency and stability during pre- and post-physics simulation, proving its capability to generate simulation-ready environments for embodied AI agents.

Minzhang Li, Mingrui Li, Weichen Qin et al.

Protein automodeling from cryo-EM density maps faces unique challenges in enforcing physicochemical validity and managing conformational heterogeneity. Current solvers are often limited to static predictions or require computationally intensive heuristic searches. We present CryoACE, an end-to-end framework that reconstructs precise atomic graphs for both homogeneous and heterogeneous structures. Our method features two key innovations: an atom-centric reconstruction paradigm, where density features are sampled directly at atomic coordinates and iteratively recycled to refine structures, replacing expensive voxel convolutions for efficient multimodal fusion; and a training-free guidance mechanism that leverages predicted local resolution priors to resolve dynamic ambiguity. Validated on a newly constructed high-quality dataset, CryoACE significantly outperforms existing baselines on static benchmarks and, for the first time, unveils atomic-level dynamic conformations on complex real-world datasets like EMPIAR-10345 without relying on pre-built static structures.