Niyousha Hosseinichimeh

Ross Williams, Niyousha Hosseinichimeh, Aritra Majumdar et al.

This study offers a new paradigm of individual-level modeling to address the grand challenge of incorporating human behavior in epidemic models. Using generative artificial intelligence in an agent-based epidemic model, each agent is empowered to make its own reasonings and decisions via connecting to a large language model such as ChatGPT. Through various simulation experiments, we present compelling evidence that generative agents mimic real-world behaviors such as quarantining when sick and self-isolation when cases rise. Collectively, the agents demonstrate patterns akin to multiple waves observed in recent pandemics followed by an endemic period. Moreover, the agents successfully flatten the epidemic curve. This study creates potential to improve dynamic system modeling by offering a way to represent human brain, reasoning, and decision making.

Navid Ghaffarzadegan, Aritra Majumdar, Ross Williams et al.

We discuss the emerging new opportunity for building feedback-rich computational models of social systems using generative artificial intelligence. Referred to as Generative Agent-Based Models (GABMs), such individual-level models utilize large language models such as ChatGPT to represent human decision-making in social settings. We provide a GABM case in which human behavior can be incorporated in simulation models by coupling a mechanistic model of human interactions with a pre-trained large language model. This is achieved by introducing a simple GABM of social norm diffusion in an organization. For educational purposes, the model is intentionally kept simple. We examine a wide range of scenarios and the sensitivity of the results to several changes in the prompt. We hope the article and the model serve as a guide for building useful diffusion models that include realistic human reasoning and decision-making.

Elham Nasarian, Abhilash Neog, Kwok-Leung Tsui et al.

Integrating large language models (LLMs) into patient-facing healthcare systems offers significant potential to improve access to medical information. However, ensuring clinical safety and factual reliability remains a critical challenge. In practice, AI-generated responses may be conditionally correct yet medically inappropriate, as models often fail to interpret patient context and tend to produce agreeable responses rather than challenge unsafe assumptions. Unlike clinicians, who infer risk from incomplete information, LLMs frequently lack contextual awareness. Moreover, real-world patient interactions are open-ended and underspecified, unlike structured benchmark settings. We present CareGuardAI, a risk-aware safety framework for patient-facing medical question answering that addresses two key failure modes: clinical safety risk and hallucination risk. The framework introduces Clinical Safety Risk Assessment (SRA), inspired by ISO 14971, and Hallucination Risk Assessment (HRA) to evaluate medical risk and factual reliability. At inference time, CareGuardAI employs a multi-stage pipeline consisting of a controller agent, safety-constrained generation, and dual risk evaluation, followed by iterative refinement when necessary. Responses are released only when both SRA and HRA are less than or equal to 2, ensuring clinically acceptable outputs with bounded latency. We evaluate CareGuardAI on PatientSafeBench, MedSafetyBench, and MedHallu, covering both safety and hallucination detection. Across these benchmarks, the framework consistently outperforms strong baseline models, including GPT-4o-mini, demonstrating the importance of context-aware, risk-based, inference-time safety mechanisms for reliable deployment in healthcare.