Yoshito Otake

Mazen Soufi, Yoshito Otake, Makoto Iwasa et al.

Deep learning-based image segmentation has allowed for the fully automated, accurate, and rapid analysis of musculoskeletal (MSK) structures from medical images. However, current approaches were either applied only to 2D cross-sectional images, addressed few structures, or were validated on small datasets, which limit the application in large-scale databases. This study aimed to validate an improved deep learning model for volumetric MSK segmentation of the hip and thigh with uncertainty estimation from clinical computed tomography (CT) images. Databases of CT images from multiple manufacturers/scanners, disease status, and patient positioning were used. The segmentation accuracy, and accuracy in estimating the structures volume and density, i.e., mean HU, were evaluated. An approach for segmentation failure detection based on predictive uncertainty was also investigated. The model has shown an overall improvement with respect to all segmentation accuracy and structure volume/density evaluation metrics. The predictive uncertainty yielded large areas under the receiver operating characteristic (AUROC) curves (AUROCs>=.95) in detecting inaccurate and failed segmentations. The high segmentation and muscle volume/density estimation accuracy, along with the high accuracy in failure detection based on the predictive uncertainty, exhibited the model's reliability for analyzing individual MSK structures in large-scale CT databases.

Yi Gu, Yoshito Otake, Keisuke Uemura et al.

While most vision tasks are essentially visual in nature (for recognition), some important tasks, especially in the medical field, also require quantitative analysis (for quantification) using quantitative images. Unlike in visual analysis, pixel values in quantitative images correspond to physical metrics measured by specific devices (e.g., a depth image). However, recent work has shown that it is sometimes possible to synthesize accurate quantitative values from visual ones (e.g., depth from visual cues or defocus). This research aims to improve quantitative image synthesis (QIS) by exploring pretraining and image resolution scaling. We propose a benchmark for evaluating pretraining performance using the task of QIS-based bone mineral density (BMD) estimation from plain X-ray images, where the synthesized quantitative image is used to derive BMD. Our results show that appropriate pretraining can improve QIS performance, significantly raising the correlation of BMD estimation from 0.820 to 0.898, while others do not help or even hinder it. Scaling-up the resolution can further boost the correlation up to 0.923, a significant enhancement over conventional methods. Future work will include exploring more pretraining strategies and validating them on other image synthesis tasks.