Yilong Yang

Marcel Beetz, Yilong Yang, Abhirup Banerjee et al. · oxford

Myocardial infarction (MI) is one of the most prevalent cardiovascular diseases with associated clinical decision-making typically based on single-valued imaging biomarkers. However, such metrics only approximate the complex 3D structure and physiology of the heart and hence hinder a better understanding and prediction of MI outcomes. In this work, we investigate the utility of complete 3D cardiac shapes in the form of point clouds for an improved detection of MI events. To this end, we propose a fully automatic multi-step pipeline consisting of a 3D cardiac surface reconstruction step followed by a point cloud classification network. Our method utilizes recent advances in geometric deep learning on point clouds to enable direct and efficient multi-scale learning on high-resolution surface models of the cardiac anatomy. We evaluate our approach on 1068 UK Biobank subjects for the tasks of prevalent MI detection and incident MI prediction and find improvements of ~13% and ~5% respectively over clinical benchmarks. Furthermore, we analyze the role of each ventricle and cardiac phase for 3D shape-based MI detection and conduct a visual analysis of the morphological and physiological patterns typically associated with MI outcomes.

Yilong Yang, Srinandan Dasmahapatra, Sasan Mahmoodi

Incorporating either rotation equivariance or scale equivariance into CNNs has proved to be effective in improving models' generalization performance. However, jointly integrating rotation and scale equivariance into CNNs has not been widely explored. Digital histology imaging of biopsy tissue can be captured at arbitrary orientation and magnification and stored at different resolutions, resulting in cells appearing in different scales. When conventional CNNs are applied to histopathology image analysis, the generalization performance of models is limited because 1) a part of the parameters of filters are trained to fit rotation transformation, thus decreasing the capability of learning other discriminative features; 2) fixed-size filters trained on images at a given scale fail to generalize to those at different scales. To deal with these issues, we propose the Rotation-Scale Equivariant Steerable Filter (RSESF), which incorporates steerable filters and scale-space theory. The RSESF contains copies of filters that are linear combinations of Gaussian filters, whose direction is controlled by directional derivatives and whose scale parameters are trainable but constrained to span disjoint scales in successive layers of the network. Extensive experiments on two gland segmentation datasets demonstrate that our method outperforms other approaches, with much fewer trainable parameters and fewer GPU resources required. The source code is available at: https://github.com/ynulonger/RSESF.

Haowei Wang, Jiayi Ji, Tianyu Guo et al.

Panoptic Narrative Detection (PND) and Segmentation (PNS) are two challenging tasks that involve identifying and locating multiple targets in an image according to a long narrative description. In this paper, we propose a unified and effective framework called NICE that can jointly learn these two panoptic narrative recognition tasks. Existing visual grounding tasks use a two-branch paradigm, but applying this directly to PND and PNS can result in prediction conflict due to their intrinsic many-to-many alignment property. To address this, we introduce two cascading modules based on the barycenter of the mask, which are Coordinate Guided Aggregation (CGA) and Barycenter Driven Localization (BDL), responsible for segmentation and detection, respectively. By linking PNS and PND in series with the barycenter of segmentation as the anchor, our approach naturally aligns the two tasks and allows them to complement each other for improved performance. Specifically, CGA provides the barycenter as a reference for detection, reducing BDL's reliance on a large number of candidate boxes. BDL leverages its excellent properties to distinguish different instances, which improves the performance of CGA for segmentation. Extensive experiments demonstrate that NICE surpasses all existing methods by a large margin, achieving 4.1% for PND and 2.9% for PNS over the state-of-the-art. These results validate the effectiveness of our proposed collaborative learning strategy. The project of this work is made publicly available at https://github.com/Mr-Neko/NICE.

Yani Wang, Yilong Yang, Yang Liu et al.

Multimodal Large Language Models (MLLMs) have recently demonstrated remarkable capabilities in content synthesis and autonomous reasoning. Previous safety guardrails are primarily designed for unimodal textual input interception, leaving them vulnerable to cross-modal jailbreak attacks. However, regardless unimodal textual attack or cross-modal jailbreak, typically inclusive part of explicit harmful or sensitive content at the input level, which is called Harm-Bearing. It allow the model's safety filters to detect and block such content easily. To address this limitations, we propose Distributed Semantic Recomposition (DSR), a novel cross-modal jailbreak framework that decomposes harmful intent into a set of benign textual and visual primitives. By exploiting the model's reasoning ability, DSR enables the latent fusion of these seemingly innocent components into harmful outputs during the cross-modal inference phase. Extensive experiments on multiple commercial MLLMs pipelines demonstrate that DSR achieves superior attack success rates while maintaining an extremely low or even negligible input toxicity rate. Our findings uncover a critical Utility-Safety Paradox in MLLMs, where the model's instruction-following proficiency facilitates its own cognitive exploitation. Content Warning: This paper contains harmful model responses.

Yilong Yang, Srinandan Dasmahapatra, Sasan Mahmoodi

The UNet model consists of fully convolutional network (FCN) layers arranged as contracting encoder and upsampling decoder maps. Nested arrangements of these encoder and decoder maps give rise to extensions of the UNet model, such as UNete and UNet++. Other refinements include constraining the outputs of the convolutional layers to discriminate between segment labels when trained end to end, a property called deep supervision. This reduces feature diversity in these nested UNet models despite their large parameter space. Furthermore, for texture segmentation, pixel correlations at multiple scales contribute to the classification task; hence, explicit deep supervision of shallower layers is likely to enhance performance. In this paper, we propose ADS UNet, a stage-wise additive training algorithm that incorporates resource-efficient deep supervision in shallower layers and takes performance-weighted combinations of the sub-UNets to create the segmentation model. We provide empirical evidence on three histopathology datasets to support the claim that the proposed ADS UNet reduces correlations between constituent features and improves performance while being more resource efficient. We demonstrate that ADS_UNet outperforms state-of-the-art Transformer-based models by 1.08 and 0.6 points on CRAG and BCSS datasets, and yet requires only 37% of GPU consumption and 34% of training time as that required by Transformers.

Yilong Yang, Srinandan Dasmahapatra, Sasan Mahmoodi

Digital histopathology slides are scanned and viewed under different magnifications and stored as images at different resolutions. Convolutional Neural Networks (CNNs) trained on such images at a given scale fail to generalise to those at different scales. This inability is often addressed by augmenting training data with re-scaled images, allowing a model with sufficient capacity to learn the requisite patterns. Alternatively, designing CNN filters to be scale-equivariant frees up model capacity to learn discriminative features. In this paper, we propose the Scale-Equivariant UNet (SEUNet) for image segmentation by building on scale-space theory. The SEUNet contains groups of filters that are linear combinations of Gaussian basis filters, whose scale parameters are trainable but constrained to span disjoint scales through the layers of the network. Extensive experiments on a nuclei segmentation dataset and a tissue type segmentation dataset demonstrate that our method outperforms other approaches, with much fewer trainable parameters.

Yule Liu, Yilong Yang, Jiale Teng et al.

Recent advances in image-to-3D models have significantly improved the fidelity and accessibility of 3D content creation. Such a powerful reconstruction capability that enables creative design can also be misused by the adversary to generate harmful geometries, which can be further fabricated via 3D printers and pose real-world risks. However, such risks are largely underexplored: it remains unclear how well current image-to-3D models can produce these harmful geometries, and whether existing safeguards can reliably prevent such generation. To fill this gap, we conduct a systematic measurement study of harmful geometry generation and mitigation. We first describe this risk through three kinds of unsafe categories: direct-use physical hazards, risky templates or components, and deceptive replicas. Each category is instantiated with representative objects. We evaluate both open-source and commercial image-to-3D models under original, degraded, viewpoint-shifted, and semantically camouflaged inputs. We consider different evaluation metrics, including geometric validity, multi-view VLM-based semantic scoring, targeted human validation, and controlled physical fabrication. The results reveal a concerning reality that current image-to-3D models can effectively reconstruct the harmful geometries, while fewer than 0.3% of such geometries trigger commercial moderation flags. As a first step toward mitigation, we evaluate three representative safeguard families, including input moderation, model-level benign alignment, and output-level filtering. We find that existing safeguards have distinct weaknesses. We further develop a stacked defense that can reduce harmful retention to <1%, but still at 11% overall false-positive cost. Taken together, our findings demonstrate that the risk in current system and encourage better geometry-aware safeguards for moderation.

Hao Yang, Zhuo Ma, Yang Liu et al.

Large vision-language models (LVLMs) have emerged as a powerful paradigm for multimodal intelligence, but their growing deployment also expands the attack surface of prompt injection. Despite this growing concern, existing attacks still suffer from a critical limitation: the injected prompt for one modality only steers the model's interpretation of that singular input. Alternatively, these attacks remain multimodal but fail to achieve cross-modal prompt perturbation. To bridge this gap, we introduce a novel cross-modal prompt injection attack CrossMPI, which can steer the model's interpretation of both textual and visual inputs via image-only prompt injection. Our design is underpinned by the following key breakthroughs. First, we turn the focus of the injected prompt perturbation optimization from the visual embedding space (typically with only $10^5$ parameters) to the model hidden state space (for multimodal information integration and with $10^7$ parameters). Then, two strategies are adopted to mitigate the optimization challenges posed by the larger parameter space. To constrain the optimized model parameter space, we introduce a layer selection strategy that identifies the layers most critical to multimodal integration. Interestingly, deviating from the past experience, our analysis reveals that the optimal layers for LVLM prompt perturbation reside in the middle of the model rather than the last. To constrain the image perturbation space, we propose a new distance-decremental perturbation budget assignment strategy that allocates budgets decrementally as the pixel distance to semantic-critical regions increases. Extensive experiments across multiple LVLMs and datasets show that our method significantly outperforms baseline approaches.

Taifeng Liu, Xinjing Liu, Liangqiu Dong et al.

Current adversarial examples (AEs) are typically designed for static models. However, with the wide application of Class-Incremental Learning (CIL), models are no longer static and need to be updated with new data distributed and labeled differently from the old ones. As a result, existing AEs often fail after CIL updates due to significant domain drift. In this paper, we propose SAE to enhance the sustainability of AEs against CIL. The core idea of SAE is to enhance the robustness of AE semantics against domain drift by making them more similar to the target class while distinguishing them from all other classes. Achieving this is challenging, as relying solely on the initial CIL model to optimize AE semantics often leads to overfitting. To resolve the problem, we propose a Semantic Correction Module. This module encourages the AE semantics to be generalized, based on a visual-language model capable of producing universal semantics. Additionally, it incorporates the CIL model to correct the optimization direction of the AE semantics, guiding them closer to the target class. To further reduce fluctuations in AE semantics, we propose a Filtering-and-Augmentation Module, which first identifies non-target examples with target-class semantics in the latent space and then augments them to foster more stable semantics. Comprehensive experiments demonstrate that SAE outperforms baselines by an average of 31.28% when updated with a 9-fold increase in the number of classes.

Yilong Yang, Jianxin Tian, Shengchuan Zhang et al.

Current zero-shot Camouflaged Object Segmentation methods typically employ a two-stage pipeline (discover-then-segment): using MLLMs to obtain visual prompts, followed by SAM segmentation. However, relying solely on MLLMs for camouflaged object discovery often leads to inaccurate localization, false positives, and missed detections. To address these issues, we propose the \textbf{D}iscover-\textbf{S}egment-\textbf{S}elect (\textbf{DSS}) mechanism, a progressive framework designed to refine segmentation step by step. The proposed method contains a Feature-coherent Object Discovery (FOD) module that leverages visual features to generate diverse object proposals, a segmentation module that refines these proposals through SAM segmentation, and a Semantic-driven Mask Selection (SMS) module that employs MLLMs to evaluate and select the optimal segmentation mask from multiple candidates. Without requiring any training or supervision, DSS achieves state-of-the-art performance on multiple COS benchmarks, especially in multiple-instance scenes.

Zhen Sun, Zongmin Zhang, Deqi Liang et al.

As LLMs become more common, non-expert users can pose risks, prompting extensive research into jailbreak attacks. However, most existing black-box jailbreak attacks rely on hand-crafted heuristics or narrow search spaces, which limit scalability. Compared with prior attacks, we propose Game-Theory Attack (GTA), an scalable black-box jailbreak framework. Concretely, we formalize the attacker's interaction against safety-aligned LLMs as a finite-horizon, early-stoppable sequential stochastic game, and reparameterize the LLM's randomized outputs via quantal response. Building on this, we introduce a behavioral conjecture "template-over-safety flip": by reshaping the LLM's effective objective through game-theoretic scenarios, the originally safety preference may become maximizing scenario payoffs within the template, which weakens safety constraints in specific contexts. We validate this mechanism with classical game such as the disclosure variant of the Prisoner's Dilemma, and we further introduce an Attacker Agent that adaptively escalates pressure to increase the ASR. Experiments across multiple protocols and datasets show that GTA achieves over 95% ASR on LLMs such as Deepseek-R1, while maintaining efficiency. Ablations over components, decoding, multilingual settings, and the Agent's core model confirm effectiveness and generalization. Moreover, scenario scaling studies further establish scalability. GTA also attains high ASR on other game-theoretic scenarios, and one-shot LLM-generated variants that keep the model mechanism fixed while varying background achieve comparable ASR. Paired with a Harmful-Words Detection Agent that performs word-level insertions, GTA maintains high ASR while lowering detection under prompt-guard models. Beyond benchmarks, GTA jailbreaks real-world LLM applications and reports a longitudinal safety monitoring of popular HuggingFace LLMs.

Yule Liu, Heyi Zhang, Jinyi Zheng et al.

Membership inference attacks (MIAs) on large language models (LLMs) pose significant privacy risks across various stages of model training. Recent advances in Reinforcement Learning with Verifiable Rewards (RLVR) have brought a profound paradigm shift in LLM training, particularly for complex reasoning tasks. However, the on-policy nature of RLVR introduces a unique privacy leakage pattern: since training relies on self-generated responses without fixed ground-truth outputs, membership inference must now determine whether a given prompt (independent of any specific response) is used during fine-tuning. This creates a threat where leakage arises not from answer memorization. To audit this novel privacy risk, we propose Divergence-in-Behavior Attack (DIBA), the first membership inference framework specifically designed for RLVR. DIBA shifts the focus from memorization to behavioral change, leveraging measurable shifts in model behavior across two axes: advantage-side improvement (e.g., correctness gain) and logit-side divergence (e.g., policy drift). Through comprehensive evaluations, we demonstrate that DIBA significantly outperforms existing baselines, achieving around 0.8 AUC and an order-of-magnitude higher TPR@0.1%FPR. We validate DIBA's superiority across multiple settings--including in-distribution, cross-dataset, cross-algorithm, black-box scenarios, and extensions to vision-language models. Furthermore, our attack remains robust under moderate defensive measures. To the best of our knowledge, this is the first work to systematically analyze privacy vulnerabilities in RLVR, revealing that even in the absence of explicit supervision, training data exposure can be reliably inferred through behavioral traces.

Zhuzhu Wang, Yilong Yang, Yang Liu et al.

The application of federated extreme gradient boosting to mobile crowdsensing apps brings several benefits, in particular high performance on efficiency and classification. However, it also brings a new challenge for data and model privacy protection. Besides it being vulnerable to Generative Adversarial Network (GAN) based user data reconstruction attack, there is not the existing architecture that considers how to preserve model privacy. In this paper, we propose a secret sharing based federated learning architecture FedXGB to achieve the privacy-preserving extreme gradient boosting for mobile crowdsensing. Specifically, we first build a secure classification and regression tree (CART) of XGBoost using secret sharing. Then, we propose a secure prediction protocol to protect the model privacy of XGBoost in mobile crowdsensing. We conduct a comprehensive theoretical analysis and extensive experiments to evaluate the security, effectiveness, and efficiency of FedXGB. The results indicate that FedXGB is secure against the honest-but-curious adversaries and attains less than 1% accuracy loss compared with the original XGBoost model.

Zhuyifan Ye, Yilong Yang, Xiaoshan Li et al.

Background: Pharmacokinetic evaluation is one of the key processes in drug discovery and development. However, current absorption, distribution, metabolism, excretion prediction models still have limited accuracy. Aim: This study aims to construct an integrated transfer learning and multitask learning approach for developing quantitative structure-activity relationship models to predict four human pharmacokinetic parameters. Methods: A pharmacokinetic dataset included 1104 U.S. FDA approved small molecule drugs. The dataset included four human pharmacokinetic parameter subsets (oral bioavailability, plasma protein binding rate, apparent volume of distribution at steady-state and elimination half-life). The pre-trained model was trained on over 30 million bioactivity data. An integrated transfer learning and multitask learning approach was established to enhance the model generalization. Results: The pharmacokinetic dataset was split into three parts (60:20:20) for training, validation and test by the improved Maximum Dissimilarity algorithm with the representative initial set selection algorithm and the weighted distance function. The multitask learning techniques enhanced the model predictive ability. The integrated transfer learning and multitask learning model demonstrated the best accuracies, because deep neural networks have the general feature extraction ability, transfer learning and multitask learning improved the model generalization. Conclusions: The integrated transfer learning and multitask learning approach with the improved dataset splitting algorithm was firstly introduced to predict the pharmacokinetic parameters. This method can be further employed in drug discovery and development.

Yilong Yang, Zhuyifan Ye, Yan Su et al.

Current pharmaceutical formulation development still strongly relies on the traditional trial-and-error approach by individual experiences of pharmaceutical scientists, which is laborious, time-consuming and costly. Recently, deep learning has been widely applied in many challenging domains because of its important capability of automatic feature extraction. The aim of this research is to use deep learning to predict pharmaceutical formulations. In this paper, two different types of dosage forms were chosen as model systems. Evaluation criteria suitable for pharmaceutics were applied to assessing the performance of the models. Moreover, an automatic dataset selection algorithm was developed for selecting the representative data as validation and test datasets. Six machine learning methods were compared with deep learning. The result shows the accuracies of both two deep neural networks were above 80% and higher than other machine learning models, which showed good prediction in pharmaceutical formulations. In summary, deep learning with the automatic data splitting algorithm and the evaluation criteria suitable for pharmaceutical formulation data was firstly developed for the prediction of pharmaceutical formulations. The cross-disciplinary integration of pharmaceutics and artificial intelligence may shift the paradigm of pharmaceutical researches from experience-dependent studies to data-driven methodologies.

Yilong Yang, Xiaoshan Li, Zhiming Liu et al.

Prototyping is an effective and efficient way of requirement validation to avoid introducing errors in the early stage of software development. However, manually developing a prototype of a software system requires additional efforts, which would increase the overall cost of software development. In this paper, we present an approach with a developed tool to automatic generation of prototypes from formal requirements models. A requirements model consists of a use case diagram, a conceptual class diagram, use case definitions specified by system sequence diagrams and the contracts of their system operations. We propose a method to decompose a contract into executable parts and non-executable parts. A set of transformation rules is given to decompose the executable part into pre-implemented primitive operations. A non-executable part is usually realized by significant algorithms such as sorting a list, finding the shortest path or domain-specific computation. It can be implemented manually or by using existing code. A CASE tool is developed that provides an interface for developers to develop a program for each non-executable part of a contract, and automatically transforms the executables into sequences of pre-implemented primitive operations. We have conducted four cases studies with over 50 use cases. The experimental result shows that the 93.65% of requirement specifications are executable, and only 6.35% are non-executable such as sorting and event-call, which can be implemented by developers manually or invoking the APIs of advanced algorithms in Java library. The one second generated the prototype of a case study requires approximate nine hours manual implementation by a skilled programmer. Overall, the result is satisfiable, and the proposed approach with the developed CASE tool can be applied to the software industry for requirements engineering.

Yilong Yang, Nafees Qamar, Peng Liu et al.

Automated service classification plays a crucial role in service discovery, selection, and composition. Machine learning has been widely used for service classification in recent years. However, the performance of conventional machine learning methods highly depends on the quality of manual feature engineering. In this paper, we present a novel deep neural network to automatically abstract low-level representation of both service name and service description to high-level merged features without feature engineering and the length limitation, and then predict service classification on 50 service categories. To demonstrate the effectiveness of our approach, we conduct a comprehensive experimental study by comparing 10 machine learning methods on 10,000 real-world web services. The result shows that the proposed deep neural network can achieve higher accuracy in classification and more robust than other machine learning methods.

Yilong Yang, Quan Zu, Peng Liu et al.

This paper takes up the problem of medical resource sharing through MicroService architecture without compromising patient privacy. To achieve this goal, we suggest refactoring the legacy EHR systems into autonomous MicroServices communicating by the unified techniques such as RESTFul web service. This lets us handle clinical data queries directly and far more efficiently for both internal and external queries. The novelty of the proposed approach lies in avoiding the data de-identification process often used as a means of preserving patient privacy. The implemented toolkit combines software engineering technologies such as Java EE, RESTful web services, JSON Web Tokens to allow exchanging medical data in an unidentifiable XML and JSON format as well as restricting users to the need-to-know principle. Our technique also inhibits retrospective processing of data such as attacks by an adversary on a medical dataset using advanced computational methods to reveal Protected Health Information (PHI). The approach is validated on an endoscopic reporting application based on openEHR and MST standards. From the usability perspective, the approach can be used to query datasets by clinical researchers, governmental or non-governmental organizations in monitoring health care and medical record services to improve quality of care and treatment.

Yilong Yang, Jing Yang, Xiaoshan Li

Unified Modeling Language (UML) is the de facto standard for requirements modeling and system design. UML as a visual language can tremendously help customers, project managers, and developers to specify the requirements of a target system. However, UML lacks the ability to specify the requirements precisely such as the contracts of the system operation, and verify the consistency and refinement of the requirements. These disadvantages result in that the potential faults of software are hard to be discovered in the early stage of software development process, and then requiring more efforts in software testing to find the bugs. Service refinement is a formal method, which could be a supplement to enhance the UML. In this paper, we show how to integrate UML with service refinement to specify requirements, and verify the consistency and refinements of the requirements through a case study of online shopping system. Particularly, requirements are modeled through UML diagrams, which includes a) use case diagram, b) system sequence diagrams and c) conceptual class diagram. Service refinement enhances the requirements model by introducing the contracts. Furthermore, the consistency and refinements of requirement model can be verified through service refinement. Our approach demonstrates integrating UML with service refinement can require fewer efforts to achieve the consistency requirements than only using UML for requirement modeling.

Yilong Yang, Xiaoshan Li, Quan Zu

With the advancement of software engineering in recent years, the model checking techniques are widely applied in various areas to do the verification for the system model. However, it is difficult to apply the model checking to verify requirements due to lacking the details of the design. Unlike other model checking tools, LTSA provides the structure diagram, which can bridge the gap between the requirements and the design. In this paper, we demonstrate the abilities of LTSA shipped with the classic case study of the steam boiler system. The structure diagram of LTSA can specify the interactions between the controller and the steam boiler, which can be derived from UML requirements model such as system sequence diagram of the steam boiler system. The start-up design model of LTSA can be generated from the structure diagram. Furthermore, we provide a variation law of the steam rate to avoid the issue of state space explosion and show how explicitly and implicitly model the time that reflects the difference between system modeling and the physical world. Finally, the derived model is verified against the required properties. Our work demonstrates the potential power of integrating UML with model checking tools in requirement elicitation, system design, and verification.

Yilong Yang, Xiaoshan Li, Nafees Qamar et al.

Legacy Electronic Health Records (EHRs) systems were not developed with the level of connectivity expected from them nowadays. Therefore, interoperability weakness inherent in the legacy systems can result in poor patient care and waste of financial resources. Large hospitals are less likely to share their data with external hospitals due to economic and political reasons. Motivated by these facts, we aim to provide a set of software implementation guidelines, i.e., MedShare to deal with interoperability issues among disconnected healthcare systems. The proposed integrated architecture includes: 1) a data extractor to fetch legacy medical data from a hemodialysis center, 2) converting it to a common data model, 3) indexing patient information using the HashMap technique, and 4) a set of services and tools that can be installed as a coherent environment on top of stand-alone EHRs systems. Our work enabled three cooperating but autonomous hospitals to mutually exchange medical data and helped them develop a common reference architecture. It lets stakeholders retain control over their patient data, winning the trust and confidence much needed towards a successful deployment of MedShare. Security concerns were effectively addressed that also included patient consent in the data exchange process. Thereby, the implemented toolset offered a collaborative environment to share EHRs by the healthcare providers.

Run Han, Yilong Yang, Xiaoshan Li et al.

Oral Disintegrating Tablets (ODTs) is a novel dosage form that can be dissolved on the tongue within 3min or less especially for geriatric and pediatric patients. Current ODT formulation studies usually rely on the personal experience of pharmaceutical experts and trial-and-error in the laboratory, which is inefficient and time-consuming. The aim of current research was to establish the prediction model of ODT formulations with direct compression process by Artificial Neural Network (ANN) and Deep Neural Network (DNN) techniques. 145 formulation data were extracted from Web of Science. All data sets were divided into three parts: training set (105 data), validation set (20) and testing set (20). ANN and DNN were compared for the prediction of the disintegrating time. The accuracy of the ANN model has reached 85.60%, 80.00% and 75.00% on the training set, validation set and testing set respectively, whereas that of the DNN model was 85.60%, 85.00% and 80.00%, respectively. Compared with the ANN, DNN showed the better prediction for ODT formulations. It is the first time that deep neural network with the improved dataset selection algorithm is applied to formulation prediction on small data. The proposed predictive approach could evaluate the critical parameters about quality control of formulation, and guide research and process development. The implementation of this prediction model could effectively reduce drug product development timeline and material usage, and proactively facilitate the development of a robust drug product.

Yilong Yang

Enterprise applications can be automatically generated from a sophisticated OO design model based on model-driven approach. The design model contains information about how to decompose the system into components, how to encapsulate the system operations into classes, and how the objects of classes collaborate to fulfill the functionality of the system operations. However, the efforts to build the design model from a validated requirements model are not proportional to the return. In practice, it is very desirable to have an approach that can automatically generate standardized enterprise applications directly from the validated requirements models. In this paper, we propose an approach named RM2EA, which can reach this goal based on the contract-based requirements model. We demonstrate the proposed approach through 13 case studies. The evaluation result shows that the quality and efficiency of the generated applications are almost equal to the applications implemented by developers: firstly, we demonstrate that a popular type of enterprise applications (i.e., a Jakarta EE application) can be successfully generated by customizing and improving the set of rules; secondly, RM2EA can generate more readable or maintainable code; thirdly, the enterprise applications generated by RM2EA achieve similar performance in test results. Overall, the result is satisfactory, and the implementation of the proposed approach can be further enhanced and applied to software development in the industry.

Nafees Qamar, Yilong Yang, Andras Nadas et al.

This paper takes on the problem of automatically identifying clinically-relevant patterns in medical datasets without compromising patient privacy. To achieve this goal, we treat datasets as a black box for both internal and external users of data that lets us handle clinical data queries directly and far more efficiently. The novelty of the approach lies in avoiding the data de-identification process often used as a means of preserving patient privacy. The implemented toolkit combines software engineering technologies such as Java EE and RESTful web services, to allow exchanging medical data in an unidentifiable XML format as well as restricting users to the need-to-know principle. Our technique also inhibits retrospective processing of data, such as attacks by an adversary on a medical dataset using advanced computational methods to reveal Protected Health Information (PHI). The approach is validated on an endoscopic reporting application based on openEHR and MST standards. From the usability perspective, the approach can be used to query datasets by clinical researchers, governmental or non-governmental organizations in monitoring health care services to improve quality of care.