Yunshu Zhang

Hao Chen, Haoran Zhou, Yunshu Zhang et al.

In the RGB-D vision community, extensive research has been focused on designing multi-modal learning strategies and fusion structures. However, the complementary and fusion mechanisms in RGB-D models remain a black box. In this paper, we present an analytical framework and a novel score to dissect the RGB-D vision community. Our approach involves measuring proposed semantic variance and feature similarity across modalities and levels, conducting visual and quantitative analyzes on multi-modal learning through comprehensive experiments. Specifically, we investigate the consistency and specialty of features across modalities, evolution rules within each modality, and the collaboration logic used when optimizing a RGB-D model. Our studies reveal/verify several important findings, such as the discrepancy in cross-modal features and the hybrid multi-modal cooperation rule, which highlights consistency and specialty simultaneously for complementary inference. We also showcase the versatility of the proposed RGB-D dissection method and introduce a straightforward fusion strategy based on our findings, which delivers significant enhancements across various tasks and even other multi-modal data.

Naim U. Rashid, Daniel J. Luckett, Jingxiang Chen et al.

The complexity of human cancer often results in significant heterogeneity in response to treatment. Precision medicine offers potential to improve patient outcomes by leveraging this heterogeneity. Individualized treatment rules (ITRs) formalize precision medicine as maps from the patient covariate space into the space of allowable treatments. The optimal ITR is that which maximizes the mean of a clinical outcome in a population of interest. Patient-derived xenograft (PDX) studies permit the evaluation of multiple treatments within a single tumor and thus are ideally suited for estimating optimal ITRs. PDX data are characterized by correlated outcomes, a high-dimensional feature space, and a large number of treatments. Existing methods for estimating optimal ITRs do not take advantage of the unique structure of PDX data or handle the associated challenges well. In this paper, we explore machine learning methods for estimating optimal ITRs from PDX data. We analyze data from a large PDX study to identify biomarkers that are informative for developing personalized treatment recommendations in multiple cancers. We estimate optimal ITRs using regression-based approaches such as Q-learning and direct search methods such as outcome weighted learning. Finally, we implement a superlearner approach to combine a set of estimated ITRs and show that the resulting ITR performs better than any of the input ITRs, mitigating uncertainty regarding user choice of any particular ITR estimation methodology. Our results indicate that PDX data are a valuable resource for developing individualized treatment strategies in oncology.