Francisco M. Couto

Pedro Ruas, Diana F. Sousa, André Neves et al.

Biomedical Natural Language Processing (NLP) tends to become cumbersome for most researchers, frequently due to the amount and heterogeneity of text to be processed. To address this challenge, the industry is continuously developing highly efficient tools and creating more flexible engineering solutions. This work presents the integration between industry data engineering solutions for efficient data processing and academic systems developed for Named Entity Recognition (LasigeUnicage\_NER) and Relation Extraction (BiOnt). Our design reflects an integration of those components with external knowledge in the form of additional training data from other datasets and biomedical ontologies. We used this pipeline in the 2022 LitCoin NLP Challenge, where our team LasigeUnicage was awarded the 7th Prize out of approximately 200 participating teams, reflecting a successful collaboration between the academia (LASIGE) and the industry (Unicage). The software supporting this work is available at \url{https://github.com/lasigeBioTM/Litcoin-Lasige_Unicage}.

Pedro Ruas, Fernando Gallego, Francisco J. Veredas et al.

State-of-the-art deep learning entity linking methods rely on extensive human-labelled data, which is costly to acquire. Current datasets are limited in size, leading to inadequate coverage of biomedical concepts and diminished performance when applied to new data. In this work, we propose to automatically generate data to create large-scale training datasets, which allows the exploration of approaches originally developed for the task of extreme multi-label ranking in the biomedical entity linking task. We propose the hybrid X-Linker pipeline that includes different modules to link disease and chemical entity mentions to concepts in the MEDIC and the CTD-Chemical vocabularies, respectively. X-Linker was evaluated on several biomedical datasets: BC5CDR-Disease, BioRED-Disease, NCBI-Disease, BC5CDR-Chemical, BioRED-Chemical, and NLM-Chem, achieving top-1 accuracies of 0.8307, 0.7969, 0.8271, 0.9511, 0.9248, and 0.7895, respectively. X-Linker demonstrated superior performance in three datasets: BC5CDR-Disease, NCBI-Disease, and BioRED-Chemical. In contrast, SapBERT outperformed X-Linker in the remaining three datasets. Both models rely only on the mention string for their operations. The source code of X-Linker and its associated data are publicly available for performing biomedical entity linking without requiring pre-labelled entities with identifiers from specific knowledge organization systems.

Andre Lamurias, Diana Sousa, Francisco M. Couto

Question Answering (QA) is a natural language processing task that aims at obtaining relevant answers to user questions. While some progress has been made in this area, biomedical questions are still a challenge to most QA approaches, due to the complexity of the domain and limited availability of training sets. We present a method to automatically extract question-article pairs from Q\&A web forums, which can be used for document retrieval, a crucial step of most QA systems. The proposed framework extracts from selected forums the questions and the respective answers that contain citations. This way, QA systems based on document retrieval can be developed and evaluated using the question-article pairs annotated by users of these forums. We generated the BiQA corpus by applying our framework to three forums, obtaining 7,453 questions and 14,239 question-article pairs. We evaluated how the number of articles associated with each question and the number of votes on each answer affects the performance of baseline document retrieval approaches. Also, we demonstrated that the articles given as answers are significantly similar to the questions and trained a state-of-the-art deep learning model that obtained similar performance to using a dataset manually annotated by experts. The proposed framework can be used to update the BiQA corpus from the same forums as new posts are made, and from other forums that support their answers with documents. The BiQA corpus and the framework used to generate it are available at \url{https://github.com/lasigeBioTM/BiQA}.

Diana Sousa, Francisco M. Couto

Successful biomedical relation extraction can provide evidence to researchers and clinicians about possible unknown associations between biomedical entities, advancing the current knowledge we have about those entities and their inherent mechanisms. Most biomedical relation extraction systems do not resort to external sources of knowledge, such as domain-specific ontologies. However, using deep learning methods, along with biomedical ontologies, has been recently shown to effectively advance the biomedical relation extraction field. To perform relation extraction, our deep learning system, BiOnt, employs four types of biomedical ontologies, namely, the Gene Ontology, the Human Phenotype Ontology, the Human Disease Ontology, and the Chemical Entities of Biological Interest, regarding gene-products, phenotypes, diseases, and chemical compounds, respectively. We tested our system with three data sets that represent three different types of relations of biomedical entities. BiOnt achieved, in F-score, an improvement of 4.93 percentage points for drug-drug interactions (DDI corpus), 4.99 percentage points for phenotype-gene relations (PGR corpus), and 2.21 percentage points for chemical-induced disease relations (BC5CDR corpus), relatively to the state-of-the-art. The code supporting this system is available at https://github.com/lasigeBioTM/BiOnt.

Sérgio Nunes, Suzanne Little, Sumit Bhatia et al.

ECIR 2020 https://ecir2020.org/ was one of the many conferences affected by the COVID-19 pandemic. The Conference Chairs decided to keep the initially planned dates (April 14-17, 2020) and move to a fully online event. In this report, we describe the experience of organizing the ECIR 2020 Workshops in this scenario from two perspectives: the workshop organizers and the workshop participants. We provide a report on the organizational aspect of these events and the consequences for participants. Covering the scientific dimension of each workshop is outside the scope of this article.

Marcia Barros, André Moitinho, Francisco M. Couto

Recommending Chemical Compounds of interest to a particular researcher is a poorly explored field. The few existent datasets with information about the preferences of the researchers use implicit feedback. The lack of Recommender Systems in this particular field presents a challenge for the development of new recommendations models. In this work, we propose a Hybrid recommender model for recommending Chemical Compounds. The model integrates collaborative-filtering algorithms for implicit feedback (Alternating Least Squares (ALS) and Bayesian Personalized Ranking(BPR)) and semantic similarity between the Chemical Compounds in the ChEBI ontology (ONTO). We evaluated the model in an implicit dataset of Chemical Compounds, CheRM. The Hybrid model was able to improve the results of state-of-the-art collaborative-filtering algorithms, especially for Mean Reciprocal Rank, with an increase of 6.7% when comparing the collaborative-filtering ALS and the Hybrid ALS_ONTO.

Diana Sousa, Andre Lamurias, Francisco M. Couto

Using different sources of information to support automated extracting of relations between biomedical concepts contributes to the development of our understanding of biological systems. The primary comprehensive source of these relations is biomedical literature. Several relation extraction approaches have been proposed to identify relations between concepts in biomedical literature, namely, using neural networks algorithms. The use of multichannel architectures composed of multiple data representations, as in deep neural networks, is leading to state-of-the-art results. The right combination of data representations can eventually lead us to even higher evaluation scores in relation extraction tasks. Thus, biomedical ontologies play a fundamental role by providing semantic and ancestry information about an entity. The incorporation of biomedical ontologies has already been proved to enhance previous state-of-the-art results.

Diana Sousa, Andre Lamurias, Francisco M. Couto

Human phenotype-gene relations are fundamental to fully understand the origin of some phenotypic abnormalities and their associated diseases. Biomedical literature is the most comprehensive source of these relations, however, we need Relation Extraction tools to automatically recognize them. Most of these tools require an annotated corpus and to the best of our knowledge, there is no corpus available annotated with human phenotype-gene relations. This paper presents the Phenotype-Gene Relations (PGR) corpus, a silver standard corpus of human phenotype and gene annotations and their relations. The corpus consists of 1712 abstracts, 5676 human phenotype annotations, 13835 gene annotations, and 4283 relations. We generated this corpus using Named-Entity Recognition tools, whose results were partially evaluated by eight curators, obtaining a precision of 87.01%. By using the corpus we were able to obtain promising results with two state-of-the-art deep learning tools, namely 78.05% of precision. The PGR corpus was made publicly available to the research community.

Miguel J. Rodrigues, Miguel Falé, Andre Lamurias et al.

This paper describes our system, dubbed WS4A (Web Services for All), that participated in the fourth edition of the BioASQ challenge (2016). We used WS4A to perform the Question and Answering (QA) task 4b, which consisted on the retrieval of relevant concepts, documents, snippets, RDF triples, exact answers and ideal answers for each given question. The novelty in our approach consists on the maximum exploitation of existing web services in each step of WS4A, such as the annotation of text, and the retrieval of metadata for each annotation. The information retrieved included concept identifiers, ontologies, ancestors, and most importantly, PubMed identifiers. The paper describes the WS4A pipeline and also presents the precision, recall and f-measure values obtained in task 4b. Our system achieved two second places in two subtasks on one of the five batches.

Diogo Goncalves, Miguel Costa, Francisco M. Couto

Nowadays, Cable TV operators provide their users multiple ways to watch TV content, such as Live TV and Video on Demand (VOD) services. In the last years, Catch-up TV has been introduced, allowing users to watch recent broadcast content whenever they want to. Understanding how the users interact with such services is important to develop solutions that may increase user satisfaction , user engagement and user consumption. In this paper, we characterize, for the first time, how users interact with a large European Cable TV operator that provides Live TV, Catch-up TV and VOD services. We analyzed many characteristics, such as the service usage, user engagement, program type, program genres and time periods. This characterization will help us to have a deeper understanding on how users interact with these different services, that may be used to enhance the recommendation systems of Cable TV providers.

Diogo Goncalves, Miguel Costa, Francisco M. Couto

Recommendation systems are being explored by Cable TV operators to improve user satisfaction with services, such as Live TV and Video on Demand (VOD) services. More recently, Catch-up TV has been introduced, allowing users to watch recent broadcast content whenever they want to. These services give users a large set of options from which they can choose from, creating an information overflow problem. Thus, recommendation systems arise as essential tools to solve this problem by helping users in their selection, which increases not only user satisfaction but also user engagement and content consumption. In this paper we present a learning to rank approach that uses contextual information and implicit feedback to improve recommendation systems for a Cable TV operator that provides Live and Catch-up TV services. We compare our approach with existing state-of-the-art algorithms and show that our approach is superior in accuracy, while maintaining high scores of diversity and serendipity.