Mohammad Shirazi

Yukiko Kawakami, Mohammad Shirazi, Ryo Shimizuwa et al.

Veterinary pharmacovigilance systems are essential for monitoring adverse drug events (ADEs), yet existing approaches often fail to capture region-specific toxicity patterns shaped by local biological and regulatory contexts. In Japan, these challenges are amplified by species-specific metabolic differences and reporting practices defined by the Ministry of Agriculture, Forestry, and Fisheries (MAFF). Most prior work relies on prediction-oriented models, limiting mechanistic interpretability. This study proposes a regulatory-integrated unsupervised framework for pattern discovery using the National Veterinary Assay Laboratory (NVAL) database. ADEs are encoded into organ system-aligned representations and adjusted for species-specific reporting biases, enabling cross-species comparison. Similarity-based clustering and dimensionality reduction are applied to identify latent toxicity structures. Analysis of 4,120 high-confidence ADE reports (9,080 drug-ADE combinations) identified three significant species clusters (p < 0.01), including hepatic-dominant patterns in companion animals (0.42 $\pm$ 0.06), renal toxicity in ruminants (0.39 $\pm$ 0.07), and dermatological sensitivity in sheep (0.35 $\pm$ 0.07). Drug-level clustering achieved 83% alignment with pharmacological classes, while cosine similarity outperformed alternative metrics (silhouette score: 0.48; cluster precision: 87%). Regulatory validation showed strong agreement with established classifications. These findings demonstrate that regulation-aligned unsupervised analysis can uncover biologically meaningful, region-specific toxicity patterns, providing an interpretable and scalable framework for veterinary drug safety assessment.

Danial Ahangarani, Mohammad Shirazi, Navid Ashraf

The extensive ubiquitous availability of sensors in smart devices and the Internet of Things (IoT) has opened up the possibilities for implementing sensor-based activity recognition. As opposed to traditional sensor time-series processing and hand-engineered feature extraction, in light of deep learning's proven effectiveness across various domains, numerous deep methods have been explored to tackle the challenges in activity recognition, outperforming the traditional signal processing and traditional machine learning approaches. In this work, by performing extensive experimental studies on two human activity recognition datasets, we investigate the performance of common deep learning and machine learning approaches as well as different training mechanisms (such as contrastive learning), and various feature representations extracted from the sensor time-series data and measure their effectiveness for the human activity recognition task.