Abdelrahman Abdelkader

Wasifur Rahman, Masum Hasan, Md Saiful Islam et al.

In this paper, we investigated whether we can 1) detect participants with ataxia-specific gait characteristics (risk-prediction), and 2) assess severity of ataxia from gait (severity-assessment) using computer vision. We created a dataset of 155 videos from 89 participants, 24 controls and 65 diagnosed with (or are pre-manifest) spinocerebellar ataxias (SCAs), performing the gait task of the Scale for the Assessment and Rating of Ataxia (SARA) from 11 medical sites located in 8 different states across the United States. We develop a computer vision pipeline to detect, track, and separate out the participants from their surroundings and construct several features from their body pose coordinates to capture gait characteristics like step width, step length, swing, stability, speed, etc. Our risk-prediction model achieves 83.06% accuracy and an 80.23% F1 score. Similarly, our severity-assessment model achieves a mean absolute error (MAE) score of 0.6225 and a Pearson's correlation coefficient score of 0.7268. Our models still performed competitively when evaluated on data from sites not used during training. Furthermore, through feature importance analysis, we found that our models associate wider steps, decreased walking speed, and increased instability with greater ataxia severity, which is consistent with previously established clinical knowledge. Our models create possibilities for remote ataxia assessment in non-clinical settings in the future, which could significantly improve accessibility of ataxia care. Furthermore, our underlying dataset was assembled from a geographically diverse cohort, highlighting its potential to further increase equity. The code used in this study is open to the public, and the anonymized body pose landmark dataset is also available upon request.

Tariq Adnan, Abdelrahman Abdelkader, Zipei Liu et al.

We present a framework to recognize Parkinson's disease (PD) through an English pangram utterance speech collected using a web application from diverse recording settings and environments, including participants' homes. Our dataset includes a global cohort of 1306 participants, including 392 diagnosed with PD. Leveraging the diversity of the dataset, spanning various demographic properties (such as age, sex, and ethnicity), we used deep learning embeddings derived from semi-supervised models such as Wav2Vec 2.0, WavLM, and ImageBind representing the speech dynamics associated with PD. Our novel fusion model for PD classification, which aligns different speech embeddings into a cohesive feature space, demonstrated superior performance over standard concatenation-based fusion models and other baselines (including models built on traditional acoustic features). In a randomized data split configuration, the model achieved an Area Under the Receiver Operating Characteristic Curve (AUROC) of 88.94% and an accuracy of 85.65%. Rigorous statistical analysis confirmed that our model performs equitably across various demographic subgroups in terms of sex, ethnicity, and age, and remains robust regardless of disease duration. Furthermore, our model, when tested on two entirely unseen test datasets collected from clinical settings and from a PD care center, maintained AUROC scores of 82.12% and 78.44%, respectively. This affirms the model's robustness and it's potential to enhance accessibility and health equity in real-world applications.