Brian Tracey

Liming Wang, Yuan Gong, Nauman Dawalatabad et al.

Automatic prediction of amyotrophic lateral sclerosis (ALS) disease progression provides a more efficient and objective alternative than manual approaches. We propose ALS longitudinal speech transformer (ALST), a neural network-based automatic predictor of ALS disease progression from longitudinal speech recordings of ALS patients. By taking advantage of high-quality pretrained speech features and longitudinal information in the recordings, our best model achieves 91.0\% AUC, improving upon the previous best model by 5.6\% relative on the ALS TDI dataset. Careful analysis reveals that ALST is capable of fine-grained and interpretable predictions of ALS progression, especially for distinguishing between rarer and more severe cases. Code is publicly available.

Hamideh Rezaee, Brian Tracey, Eric L. Miller

In this paper we demonstrate the utility of fusing energy-resolved observations of Compton scattered photons with traditional attenuation data for the joint recovery of mass density and photoelectric absorption in the context of limited view tomographic imaging applications. We begin with the development of a physical and associated numerical model for the Compton scatter process. Using this model, we propose a variational approach recovering these two material properties. In addition to the typical data-fidelity terms, the optimization functional includes regularization for both the mass density and photoelectric coefficients. We consider a novel edge-preserving method in the case of mass density. To aid in the recovery of the photoelectric information, we draw on our recent method in \cite{r15} and employ a non-local regularization scheme that builds on the fact that mass density is more stably imaged. Simulation results demonstrate clear advantages associated with the use of both scattered photon data and energy resolved information in mapping the two material properties of interest. Specifically, comparing images obtained using only conventional attenuation data with those where we employ only Compton scatter photons and images formed from the combination of the two, shows that taking advantage of both types of data for reconstruction provides far more accurate results.

Brian H. Tracey, Eric L. Miller

Recent years have seen growing interest in exploiting dual- and multi-energy measurements in computed tomography (CT) in order to characterize material properties as well as object shape. Material characterization is performed by decomposing the scene into constitutive basis functions, such as Compton scatter and photoelectric absorption functions. While well motivated physically, the joint recovery of the spatial distribution of photoelectric and Compton properties is severely complicated by the fact that the data are several orders of magnitude more sensitive to Compton scatter coefficients than to photoelectric absorption, so small errors in Compton estimates can create large artifacts in the photoelectric estimate. To address these issues, we propose a model-based iterative approach which uses patch-based regularization terms to stabilize inversion of photoelectric coefficients, and solve the resulting problem though use of computationally attractive Alternating Direction Method of Multipliers (ADMM) solution techniques. Using simulations and experimental data acquired on a commercial scanner, we demonstrate that the proposed processing can lead to more stable material property estimates which should aid materials characterization in future dual- and multi-energy CT systems.

Yue Wu, Brian Tracey, Premkumar Natarajan et al.

In this letter, we investigate the shrinkage problem for the non-local means (NLM) image denoising. In particular, we derive the closed-form of the optimal blockwise shrinkage for NLM that minimizes the Stein's unbiased risk estimator (SURE). We also propose a constant complexity algorithm allowing fast blockwise shrinkage. Simulation results show that the proposed blockwise shrinkage method improves NLM performance in attaining higher peak signal noise ratio (PSNR) and structural similarity index (SSIM), and makes NLM more robust against parameter changes. Similar ideas can be applicable to other patchwise image denoising techniques.

Yue Wu, Brian Tracey, Premkumar Natarajan et al.

In this paper, we propose a so-called probabilistic non-local means (PNLM) method for image denoising. Our main contributions are: 1) we point out defects of the weight function used in the classic NLM; 2) we successfully derive all theoretical statistics of patch-wise differences for Gaussian noise; and 3) we employ this prior information and formulate the probabilistic weights truly reflecting the similarity between two noisy patches. The probabilistic nature of the new weight function also provides a theoretical basis to choose thresholds rejecting dissimilar patches for fast computations. Our simulation results indicate the PNLM outperforms the classic NLM and many NLM recent variants in terms of peak signal noise ratio (PSNR) and structural similarity (SSIM) index. Encouraging improvements are also found when we replace the NLM weights with the probabilistic weights in tested NLM variants.