Lidia Talavera-Martínez

Lidia Talavera-Martinez, Philipp Tschandl

Background: As available medical image datasets increase in size, it becomes infeasible for clinicians to review content manually for knowledge extraction. The objective of this study was to create an automated clustering resulting in human-interpretable pattern discovery. Methods: Images from the public HAM10000 dataset, including 7 common pigmented skin lesion diagnoses, were tiled into 29420 tiles and clustered via k-means using neural network-extracted image features. The final number of clusters per diagnosis was chosen by either the elbow method or a compactness metric balancing intra-lesion variance and cluster numbers. The amount of resulting non-informative clusters, defined as those containing less than six image tiles, was compared between the two methods. Results: Applying k-means, the optimal elbow cutoff resulted in a mean of 24.7 (95%-CI: 16.4-33) clusters for every included diagnosis, including 14.9% (95% CI: 0.8-29.0) non-informative clusters. The optimal cutoff, as estimated by the compactness metric, resulted in significantly fewer clusters (13.4; 95%-CI 11.8-15.1; p=0.03) and less non-informative ones (7.5%; 95% CI: 0-19.5; p=0.017). The majority of clusters (93.6%) from the compactness metric could be manually mapped to previously described dermatoscopic diagnostic patterns. Conclusions: Automatically constraining unsupervised clustering can produce an automated extraction of diagnostically relevant and human-interpretable clusters of visual patterns from a large image dataset.

Lidia Talavera-Martínez, Pedro Bibiloni, Manuel González-Hidalgo

The process of removing occluding hair has a relevant role in the early and accurate diagnosis of skin cancer. It consists of detecting hairs and restore the texture below them, which is sporadically occluded. In this work, we present a model based on convolutional neural networks for hair removal in dermoscopic images. During the network's training, we use a combined loss function to improve the restoration ability of the proposed model. In order to train the CNN and to quantitatively validate their performance, we simulate the presence of skin hair in hairless images extracted from publicly known datasets such as the PH2, dermquest, dermis, EDRA2002, and the ISIC Data Archive. As far as we know, there is no other hair removal method based on deep learning. Thus, we compare our results with six state-of-the-art algorithms based on traditional computer vision techniques by means of similarity measures that compare the reference hairless image and the one with hair simulated. Finally, a statistical test is used to compare the methods. Both qualitative and quantitative results demonstrate the effectiveness of our network.