Cheng Xue

Cheng Xue, Lequan Yu, Pengfei Chen et al.

Deep neural networks have achieved remarkable success in a wide variety of natural image and medical image computing tasks. However, these achievements indispensably rely on accurately annotated training data. If encountering some noisy-labeled images, the network training procedure would suffer from difficulties, leading to a sub-optimal classifier. This problem is even more severe in the medical image analysis field, as the annotation quality of medical images heavily relies on the expertise and experience of annotators. In this paper, we propose a novel collaborative training paradigm with global and local representation learning for robust medical image classification from noisy-labeled data to combat the lack of high quality annotated medical data. Specifically, we employ the self-ensemble model with a noisy label filter to efficiently select the clean and noisy samples. Then, the clean samples are trained by a collaborative training strategy to eliminate the disturbance from imperfect labeled samples. Notably, we further design a novel global and local representation learning scheme to implicitly regularize the networks to utilize noisy samples in a self-supervised manner. We evaluated our proposed robust learning strategy on four public medical image classification datasets with three types of label noise,ie,random noise, computer-generated label noise, and inter-observer variability noise. Our method outperforms other learning from noisy label methods and we also conducted extensive experiments to analyze each component of our method.

Qixiang Zhang, Yi Li, Cheng Xue et al.

Designing deep learning algorithms for gland segmentation is crucial for automatic cancer diagnosis and prognosis, yet the expensive annotation cost hinders the development and application of this technology. In this paper, we make a first attempt to explore a deep learning method for unsupervised gland segmentation, where no manual annotations are required. Existing unsupervised semantic segmentation methods encounter a huge challenge on gland images: They either over-segment a gland into many fractions or under-segment the gland regions by confusing many of them with the background. To overcome this challenge, our key insight is to introduce an empirical cue about gland morphology as extra knowledge to guide the segmentation process. To this end, we propose a novel Morphology-inspired method via Selective Semantic Grouping. We first leverage the empirical cue to selectively mine out proposals for gland sub-regions with variant appearances. Then, a Morphology-aware Semantic Grouping module is employed to summarize the overall information about the gland by explicitly grouping the semantics of its sub-region proposals. In this way, the final segmentation network could learn comprehensive knowledge about glands and produce well-delineated, complete predictions. We conduct experiments on GlaS dataset and CRAG dataset. Our method exceeds the second-best counterpart over 10.56% at mIOU.

Sheng Zhang, Minheng Chen, Junxian Wu et al.

Vertebrae identification in arbitrary fields-of-view plays a crucial role in diagnosing spine disease. Most spine CT contain only local regions, such as the neck, chest, and abdomen. Therefore, identification should not depend on specific vertebrae or a particular number of vertebrae being visible. Existing methods at the spine-level are unable to meet this challenge. In this paper, we propose a three-stage method to address the challenges in 3D CT vertebrae identification at vertebrae-level. By sequentially performing the tasks of vertebrae localization, segmentation, and identification, the anatomical prior information of the vertebrae is effectively utilized throughout the process. Specifically, we introduce a dual-factor density clustering algorithm to acquire localization information for individual vertebra, thereby facilitating subsequent segmentation and identification processes. In addition, to tackle the issue of interclass similarity and intra-class variability, we pre-train our identification network by using a supervised contrastive learning method. To further optimize the identification results, we estimated the uncertainty of the classification network and utilized the message fusion module to combine the uncertainty scores, while aggregating global information about the spine. Our method achieves state-of-the-art results on the VerSe19 and VerSe20 challenge benchmarks. Additionally, our approach demonstrates outstanding generalization performance on an collected dataset containing a wide range of abnormal cases.

Cheng Xue, Qiao Deng, Xiaomeng Li et al.

The superior performance of CNN on medical image analysis heavily depends on the annotation quality, such as the number of labeled image, the source of image, and the expert experience. The annotation requires great expertise and labour. To deal with the high inter-rater variability, the study of imperfect label has great significance in medical image segmentation tasks. In this paper, we present a novel cascaded robust learning framework for chest X-ray segmentation with imperfect annotation. Our model consists of three independent network, which can effectively learn useful information from the peer networks. The framework includes two stages. In the first stage, we select the clean annotated samples via a model committee setting, the networks are trained by minimizing a segmentation loss using the selected clean samples. In the second stage, we design a joint optimization framework with label correction to gradually correct the wrong annotation and improve the network performance. We conduct experiments on the public chest X-ray image datasets collected by Shenzhen Hospital. The results show that our methods could achieve a significant improvement on the accuracy in segmentation tasks compared to the previous methods.

Cheng Xue, Lei Zhu, Huazhu Fu et al.

Automatic breast lesion segmentation in ultrasound helps to diagnose breast cancer, which is one of the dreadful diseases that affect women globally. Segmenting breast regions accurately from ultrasound image is a challenging task due to the inherent speckle artifacts, blurry breast lesion boundaries, and inhomogeneous intensity distributions inside the breast lesion regions. Recently, convolutional neural networks (CNNs) have demonstrated remarkable results in medical image segmentation tasks. However, the convolutional operations in a CNN often focus on local regions, which suffer from limited capabilities in capturing long-range dependencies of the input ultrasound image, resulting in degraded breast lesion segmentation accuracy. In this paper, we develop a deep convolutional neural network equipped with a global guidance block (GGB) and breast lesion boundary detection (BD) modules for boosting the breast ultrasound lesion segmentation. The GGB utilizes the multi-layer integrated feature map as a guidance information to learn the long-range non-local dependencies from both spatial and channel domains. The BD modules learn additional breast lesion boundary map to enhance the boundary quality of a segmentation result refinement. Experimental results on a public dataset and a collected dataset show that our network outperforms other medical image segmentation methods and the recent semantic segmentation methods on breast ultrasound lesion segmentation. Moreover, we also show the application of our network on the ultrasound prostate segmentation, in which our method better identifies prostate regions than state-of-the-art networks.

Xueying Shi, Qi Dou, Cheng Xue et al.

Automated skin lesion analysis is very crucial in clinical practice, as skin cancer is among the most common human malignancy. Existing approaches with deep learning have achieved remarkable performance on this challenging task, however, heavily relying on large-scale labelled datasets. In this paper, we present a novel active learning framework for cost-effective skin lesion analysis. The goal is to effectively select and utilize much fewer labelled samples, while the network can still achieve state-of-the-art performance. Our sample selection criteria complementarily consider both informativeness and representativeness, derived from decoupled aspects of measuring model certainty and covering sample diversity. To make wise use of the selected samples, we further design a simple yet effective strategy to aggregate intra-class images in pixel space, as a new form of data augmentation. We validate our proposed method on data of ISIC 2017 Skin Lesion Classification Challenge for two tasks. Using only up to 50% of samples, our approach can achieve state-of-the-art performances on both tasks, which are comparable or exceeding the accuracies with full-data training, and outperform other well-known active learning methods by a large margin.

Cheng Xue, Qi Dou, Xueying Shi et al.

Deep neural networks (DNNs) have achieved great success in a wide variety of medical image analysis tasks. However, these achievements indispensably rely on the accurately-annotated datasets. If with the noisy-labeled images, the training procedure will immediately encounter difficulties, leading to a suboptimal classifier. This problem is even more crucial in the medical field, given that the annotation quality requires great expertise. In this paper, we propose an effective iterative learning framework for noisy-labeled medical image classification, to combat the lacking of high quality annotated medical data. Specifically, an online uncertainty sample mining method is proposed to eliminate the disturbance from noisy-labeled images. Next, we design a sample re-weighting strategy to preserve the usefulness of correctly-labeled hard samples. Our proposed method is validated on skin lesion classification task, and achieved very promising results.