Shan Zeng

Zijie Fang, Yihan Liu, Yifeng Wang et al.

Biomarker detection is an indispensable part in the diagnosis and treatment of low-grade glioma (LGG). However, current LGG biomarker detection methods rely on expensive and complex molecular genetic testing, for which professionals are required to analyze the results, and intra-rater variability is often reported. To overcome these challenges, we propose an interpretable deep learning pipeline, a Multi-Biomarker Histomorphology Discoverer (Multi-Beholder) model based on the multiple instance learning (MIL) framework, to predict the status of five biomarkers in LGG using only hematoxylin and eosin-stained whole slide images and slide-level biomarker status labels. Specifically, by incorporating the one-class classification into the MIL framework, accurate instance pseudo-labeling is realized for instance-level supervision, which greatly complements the slide-level labels and improves the biomarker prediction performance. Multi-Beholder demonstrates superior prediction performance and generalizability for five LGG biomarkers (AUROC=0.6469-0.9735) in two cohorts (n=607) with diverse races and scanning protocols. Moreover, the excellent interpretability of Multi-Beholder allows for discovering the quantitative and qualitative correlations between biomarker status and histomorphology characteristics. Our pipeline not only provides a novel approach for biomarker prediction, enhancing the applicability of molecular treatments for LGG patients but also facilitates the discovery of new mechanisms in molecular functionality and LGG progression.

Yu Luo, Xiaogang Zhu, Shan Zeng et al.

Accurate crop yield prediction is crucial for sustainable agriculture and global food security. While existing methods are predominantly developed for single-crop prediction, they often struggle to generalize across diverse crop types, without addressing the unique crop phenological responses that are dynamically modulated by complex weather patterns. In this paper, we propose PhenoYieldNet, a multi-crop yield prediction framework that learns crop-specific phenology by explicitly modeling their responses with temporal drivers. Specifically, we develop a crop-aware temporal decoder consisting of a Crop Phenology Bank (CPB) and a Crop Phenology Attention (CPA) module. The CPB integrates a set of learnable embeddings, which leverage a query to guide the CPA module to learn the most relevant phenology patterns for the specific crop. And the CPA module explicitly captures multi-scale trend and variation components to construct temporal contexts, enabling the model to dynamically adjust the attention across different phenological stages. To learn robust and generalizable features for multi-crop prediction, the encoder is initialized with a pre-trained foundation model, and further adapted via a self-supervised Temporal Contrastive Adaptation strategy to align with agricultural temporal dynamics. Extensive experiments conducted on multi-crop datasets indicate that our proposed method significantly outperforms state-of-the-art methods, exhibiting strong generalization capabilities across different regions and crops.

Kun Hu, Zhiyong Wang, Guy Coleman et al.

Weeds are a significant threat to the agricultural productivity and the environment. The increasing demand for sustainable agriculture has driven innovations in accurate weed control technologies aimed at reducing the reliance on herbicides. With the great success of deep learning in various vision tasks, many promising image-based weed detection algorithms have been developed. This paper reviews recent developments of deep learning techniques in the field of image-based weed detection. The review begins with an introduction to the fundamentals of deep learning related to weed detection. Next, recent progresses on deep weed detection are reviewed with the discussion of the research materials including public weed datasets. Finally, the challenges of developing practically deployable weed detection methods are summarized, together with the discussions of the opportunities for future research.We hope that this review will provide a timely survey of the field and attract more researchers to address this inter-disciplinary research problem.