Xujing Yao

Cheng Kang, Xujing Yao

How can the stability and efficiency of Artificial Neural Networks (ANNs) be ensured through a systematic analysis method? This paper seeks to address that query. While numerous factors can influence the learning process of ANNs, utilizing knowledge from control systems allows us to analyze its system function and simulate system responses. Although the complexity of most ANNs is extremely high, we still can analyze each factor (e.g., optimiser, hyperparameters) by simulating their system response. This new method also can potentially benefit the development of new optimiser and learning system, especially when discerning which components adversely affect ANNs. Controlling ANNs can benefit from the design of optimiser and learning system, as (1) all optimisers act as controllers, (2) all learning systems operate as control systems with inputs and outputs, and (3) the optimiser should match the learning system. Please find codes: \url{https://github.com/RandomUserName2023/Control-ANNs}.

Lei Tong, Xujing Yao, Adam Corrigan et al.

High-Content Screening routinely generates massive volumes of cell painting images for phenotypic profiling. However, technical variations across experimental executions inevitably induce biological batch (bio-batch) effects. These cause covariate shifts and degrade the generalization of deep learning models on unseen data. Existing batch correction methods typically rely on additional prior knowledge (e.g., treatment or cell culture information) or struggle to generalize to unseen bio-batches. In this work, we frame bio-batch mitigation as a Domain Generalization (DG) problem and propose Adversarial Batch Representation Augmentation (ABRA). ABRA explicitly models batch-wise statistical fluctuations by parameterizing feature statistics as structured uncertainties. Through a min-max optimization framework, it actively synthesizes worst-case bio-batch perturbations in the representation space, guided by a strict angular geometric margin to preserve fine-grained class discriminability. To prevent representation collapse during this adversarial exploration, we introduce a synergistic distribution alignment objective. Extensive evaluations on the large-scale RxRx1 and RxRx1-WILDS benchmarks demonstrate that ABRA establishes a new state-of-the-art for siRNA perturbation classification.

Cheng Kang, Xinye Chen, Daniel Novak et al.

To explore the feasibility of avoiding the confident error (or hallucination) of generation models (GMs), we formalise the system of GMs as a class of stochastic dynamical systems through the lens of control theory. Numerous factors can be attributed to the hallucination of the learning process of GMs, utilising knowledge of control theory allows us to analyse their system functions and system responses. Due to the high complexity of GMs when using various optimization methods, we cannot figure out their solution of Laplace transform, but from a macroscopic perspective, simulating the source response provides a virtual way to address the hallucination of GMs. We also find that the training progress is consistent with the corresponding system response, which offers us a useful way to develop a better optimization component. Finally, the hallucination problem of GMs is fundamentally optimized by using Laplace transform analysis.