Zehong Zhang

Zehong Zhang, Fei Lu, Esther Xu Fei et al. · oxford

Statistical optimality benchmarking is crucial for analyzing and designing time series classification (TSC) algorithms. This study proposes to benchmark the optimality of TSC algorithms in distinguishing diffusion processes by the likelihood ratio test (LRT). The LRT is an optimal classifier by the Neyman-Pearson lemma. The LRT benchmarks are computationally efficient because the LRT does not need training, and the diffusion processes can be efficiently simulated and are flexible to reflect the specific features of real-world applications. We demonstrate the benchmarking with three widely-used TSC algorithms: random forest, ResNet, and ROCKET. These algorithms can achieve the LRT optimality for univariate time series and multivariate Gaussian processes. However, these model-agnostic algorithms are suboptimal in classifying high-dimensional nonlinear multivariate time series. Additionally, the LRT benchmark provides tools to analyze the dependence of classification accuracy on the time length, dimension, temporal sampling frequency, and randomness of the time series.

Dongjian Huo, Zehong Zhang, Hanjing Su et al.

Watermarking serves as a widely adopted approach to safeguard media copyright. In parallel, the research focus has extended to watermark removal techniques, offering an adversarial means to enhance watermark robustness and foster advancements in the watermarking field. Existing watermark removal methods mainly rely on UNet with task-specific decoder branches--one for watermark localization and the other for background image restoration. However, watermark localization and background restoration are not isolated tasks; precise watermark localization inherently implies regions necessitating restoration, and the background restoration process contributes to more accurate watermark localization. To holistically integrate information from both branches, we introduce an implicit joint learning paradigm. This empowers the network to autonomously navigate the flow of information between implicit branches through a gate mechanism. Furthermore, we employ cross-channel attention to facilitate local detail restoration and holistic structural comprehension, while harnessing nested structures to integrate multi-scale information. Extensive experiments are conducted on various challenging benchmarks to validate the effectiveness of our proposed method. The results demonstrate our approach's remarkable superiority, surpassing existing state-of-the-art methods by a large margin.

Yuxi Lin, Yaxue Fang, Zehong Zhang et al.

Understanding how 5' untranslated regions (5'UTRs) regulate mRNA translation is critical for controlling protein expression and designing effective therapeutic mRNAs. While recent deep learning models have shown promise in predicting translational efficiency from 5'UTR sequences, most are constrained by fixed input lengths and limited interpretability. We introduce UTR-STCNet, a Transformer-based architecture for flexible and biologically grounded modeling of variable-length 5'UTRs. UTR-STCNet integrates a Saliency-Aware Token Clustering (SATC) module that iteratively aggregates nucleotide tokens into multi-scale, semantically meaningful units based on saliency scores. A Saliency-Guided Transformer (SGT) block then captures both local and distal regulatory dependencies using a lightweight attention mechanism. This combined architecture achieves efficient and interpretable modeling without input truncation or increased computational cost. Evaluated across three benchmark datasets, UTR-STCNet consistently outperforms state-of-the-art baselines in predicting mean ribosome load (MRL), a key proxy for translational efficiency. Moreover, the model recovers known functional elements such as upstream AUGs and Kozak motifs, highlighting its potential for mechanistic insight into translation regulation.