Heng Chen

Xin Zhao, Lin Wang, Qinfei Li et al.

Establishing a realistic three-dimensional (3D) microstructure is a crucial step for studying microstructure development of hardened cement pastes. However, acquiring 3D microstructural images for cement often involves high costs and quality compromises. This paper proposes a generative adversarial networks-based method for generating 3D microstructures from a single two-dimensional (2D) image, capable of producing high-quality and realistic 3D images at low cost. In the method, a framework (CEM3DMG) is designed to synthesize 3D images by learning microstructural information from a 2D cross-sectional image. Experimental results show that CEM3DMG can generate realistic 3D images of large size. Visual observation confirms that the generated 3D images exhibit similar microstructural features to the 2D images, including similar pore distribution and particle morphology. Furthermore, quantitative analysis reveals that reconstructed 3D microstructures closely match the real 2D microstructure in terms of gray level histogram, phase proportions, and pore size distribution. The source code for CEM3DMG is available in the GitHub repository at: https://github.com/NBICLAB/CEM3DMG.

Heng Chen, Michael L. LeBlanc, James Y. Dai

Heterogeneous treatment effects (HTE) based on patients' genetic or clinical factors are of significant interest to precision medicine. Simultaneously modeling HTE and corresponding main effects for randomized clinical trials with high-dimensional predictive markers is challenging. Motivated by the modified covariates approach, we propose a two-stage statistical learning procedure for estimating HTE with optimal efficiency augmentation, generalizing to arbitrary interaction model and exploiting powerful extreme gradient boosting trees (XGBoost). Target estimands for HTE are defined in the scale of mean difference for quantitative outcomes, or risk ratio for binary outcomes, which are the minimizers of specialized loss functions. The first stage is to estimate the main-effect equivalency of the baseline markers on the outcome, which is then used as an augmentation term in the second stage estimation for HTE. The proposed two-stage procedure is robust to model mis-specification of main effects and improves efficiency for estimating HTE through nonparametric function estimation, e.g., XGBoost. A permutation test is proposed for global assessment of evidence for HTE. An analysis of a genetic study in Prostate Cancer Prevention Trial led by the SWOG Cancer Research Network, is conducted to showcase the properties and the utilities of the two-stage method.

Gemini Team, Petko Georgiev, Ving Ian Lei et al. · deepmind, mila

In this report, we introduce the Gemini 1.5 family of models, representing the next generation of highly compute-efficient multimodal models capable of recalling and reasoning over fine-grained information from millions of tokens of context, including multiple long documents and hours of video and audio. The family includes two new models: (1) an updated Gemini 1.5 Pro, which exceeds the February version on the great majority of capabilities and benchmarks; (2) Gemini 1.5 Flash, a more lightweight variant designed for efficiency with minimal regression in quality. Gemini 1.5 models achieve near-perfect recall on long-context retrieval tasks across modalities, improve the state-of-the-art in long-document QA, long-video QA and long-context ASR, and match or surpass Gemini 1.0 Ultra's state-of-the-art performance across a broad set of benchmarks. Studying the limits of Gemini 1.5's long-context ability, we find continued improvement in next-token prediction and near-perfect retrieval (>99%) up to at least 10M tokens, a generational leap over existing models such as Claude 3.0 (200k) and GPT-4 Turbo (128k). Finally, we highlight real-world use cases, such as Gemini 1.5 collaborating with professionals on completing their tasks achieving 26 to 75% time savings across 10 different job categories, as well as surprising new capabilities of large language models at the frontier; when given a grammar manual for Kalamang, a language with fewer than 200 speakers worldwide, the model learns to translate English to Kalamang at a similar level to a person who learned from the same content.

Gheorghe Comanici, Eric Bieber, Mike Schaekermann et al. · amazon-science, baidu

In this report, we introduce the Gemini 2.X model family: Gemini 2.5 Pro and Gemini 2.5 Flash, as well as our earlier Gemini 2.0 Flash and Flash-Lite models. Gemini 2.5 Pro is our most capable model yet, achieving SoTA performance on frontier coding and reasoning benchmarks. In addition to its incredible coding and reasoning skills, Gemini 2.5 Pro is a thinking model that excels at multimodal understanding and it is now able to process up to 3 hours of video content. Its unique combination of long context, multimodal and reasoning capabilities can be combined to unlock new agentic workflows. Gemini 2.5 Flash provides excellent reasoning abilities at a fraction of the compute and latency requirements and Gemini 2.0 Flash and Flash-Lite provide high performance at low latency and cost. Taken together, the Gemini 2.X model generation spans the full Pareto frontier of model capability vs cost, allowing users to explore the boundaries of what is possible with complex agentic problem solving.

Scott Emmons, Erik Jenner, David K. Elson et al.

While chain-of-thought (CoT) monitoring is an appealing AI safety defense, recent work on "unfaithfulness" has cast doubt on its reliability. These findings highlight an important failure mode, particularly when CoT acts as a post-hoc rationalization in applications like auditing for bias. However, for the distinct problem of runtime monitoring to prevent severe harm, we argue the key property is not faithfulness but monitorability. To this end, we introduce a conceptual framework distinguishing CoT-as-rationalization from CoT-as-computation. We expect that certain classes of severe harm will require complex, multi-step reasoning that necessitates CoT-as-computation. Replicating the experimental setups of prior work, we increase the difficulty of the bad behavior to enforce this necessity condition; this forces the model to expose its reasoning, making it monitorable. We then present methodology guidelines to stress-test CoT monitoring against deliberate evasion. Applying these guidelines, we find that models can learn to obscure their intentions, but only when given significant help, such as detailed human-written strategies or iterative optimization against the monitor. We conclude that, while not infallible, CoT monitoring offers a substantial layer of defense that requires active protection and continued stress-testing.

Weifeng Wei, Heng Chen, Pengxiang Su

Magnetic Resonance Imaging (MRI) requires a trade-off between resolution, signal-to-noise ratio, and scan time, making high-resolution (HR) acquisition challenging. Therefore, super-resolution for MR image is a feasible solution. However, most existing methods face challenges in accurately learning a continuous volumetric representation from low-resolution image or require HR image for supervision. To solve these challenges, we propose a novel method for MR image super-resolution based on two-factor representation. Specifically, we factorize intensity signals into a linear combination of learnable basis and coefficient factors, enabling efficient continuous volumetric representation from low-resolution MR image. Besides, we introduce a coordinate-based encoding to capture structural relationships between sparse voxels, facilitating smooth completion in unobserved regions. Experiments on BraTS 2019 and MSSEG 2016 datasets demonstrate that our method achieves state-of-the-art performance, providing superior visual fidelity and robustness, particularly in large up-sampling scale MR image super-resolution.

Yangshu Yuan, Heng Chen, Christian Ng

Story understanding and generation have long been a challenging task in natural language processing (NLP), especially when dealing with various levels of instruction specificity. In this paper, we propose a novel approach called "Weak to Strong Instruction Tuning" for improving story generation by tuning models with instructions of varying clarity. We explore the potential of large language models (LLMs) to adapt to different types of instructions, weak and strong, and show that our method significantly enhances performance in story comprehension and generation. By leveraging the strength of instruction tuning, we train models to understand the nuances of story plots, characters, and themes while generating coherent and engaging narratives. Through extensive experiments on several benchmark datasets and comparison with state-of-the-art baselines, we demonstrate that our method outperforms existing techniques, yielding substantial improvements in both automatic evaluation metrics and human evaluations. Our work shows that adaptive instruction tuning can be a powerful tool in refining generative models for complex narrative tasks.

Yangshu Yuan, Heng Chen, Xinyi Jiang et al.

The rapid advancement of Large Language Models (LLMs) and Large Vision-Language Models (LVLMs) has enhanced our ability to process and generate human language and visual information. However, these models often struggle with complex, multi-step multi-modal instructions that require logical reasoning, dynamic feedback integration, and iterative self-correction. To address this, we propose CIMR: Contextualized Iterative Multimodal Reasoning, a novel framework that introduces a context-aware iterative reasoning and self-correction module. CIMR operates in two stages: initial reasoning and response generation, followed by iterative refinement using parsed multi-modal feedback. A dynamic fusion module deeply integrates textual, visual, and contextual features at each step. We fine-tune LLaVA-1.5-7B on the Visual Instruction Tuning (VIT) dataset and evaluate CIMR on the newly introduced Multi-modal Action Planning (MAP) dataset. CIMR achieves 91.5% accuracy, outperforming state-of-the-art models such as GPT-4V (89.2%), LLaVA-1.5 (78.5%), MiniGPT-4 (75.3%), and InstructBLIP (72.8%), demonstrating the efficacy of its iterative reasoning and self-correction capabilities in complex tasks.

Yilun Wang, Sheng Zhang, Junjie Zheng et al.

In this paper, we focus on how to locate the relevant or discriminative brain regions related with external stimulus or certain mental decease, which is also called support identification, based on the neuroimaging data. The main difficulty lies in the extremely high dimensional voxel space and relatively few training samples, easily resulting in an unstable brain region discovery (or called feature selection in context of pattern recognition). When the training samples are from different centers and have betweencenter variations, it will be even harder to obtain a reliable and consistent result. Corresponding, we revisit our recently proposed algorithm based on stability selection and structural sparsity. It is applied to the multi-center MRI data analysis for the first time. A consistent and stable result is achieved across different centers despite the between-center data variation while many other state-of-the-art methods such as two sample t-test fail. Moreover, we have empirically showed that the performance of this algorithm is robust and insensitive to several of its key parameters. In addition, the support identification results on both functional MRI and structural MRI are interpretable and can be the potential biomarkers.