Cynthia Brandt

h-index55
2papers
11,690citations

2 Papers

3.9AIJan 9, 2023
Leveraging Contextual Relatedness to Identify Suicide Documentation in Clinical Notes through Zero Shot Learning

Terri Elizabeth Workman, Joseph L. Goulet, Cynthia A. Brandt et al.

Identifying suicidality including suicidal ideation, attempts, and risk factors in electronic health record data in clinical notes is difficult. A major difficulty is the lack of training samples given the small number of true positive instances among the increasingly large number of patients being screened. This paper describes a novel methodology that identifies suicidality in clinical notes by addressing this data sparsity issue through zero-shot learning. U.S. Veterans Affairs clinical notes served as data. The training dataset label was determined using diagnostic codes of suicide attempt and self-harm. A base string associated with the target label of suicidality was used to provide auxiliary information by narrowing the positive training cases to those containing the base string. A deep neural network was trained by mapping the training documents contents to a semantic space. For comparison, we trained another deep neural network using the identical training dataset labels and bag-of-words features. The zero shot learning model outperformed the baseline model in terms of AUC, sensitivity, specificity, and positive predictive value at multiple probability thresholds. In applying a 0.90 probability threshold, the methodology identified notes not associated with a relevant ICD 10 CM code that documented suicidality, with 94 percent accuracy. This new method can effectively identify suicidality without requiring manual annotation.

60.5AIJun 24, 2020Code
Benchmark and Best Practices for Biomedical Knowledge Graph Embeddings

David Chang, Ivana Balazevic, Carl Allen et al.

Much of biomedical and healthcare data is encoded in discrete, symbolic form such as text and medical codes. There is a wealth of expert-curated biomedical domain knowledge stored in knowledge bases and ontologies, but the lack of reliable methods for learning knowledge representation has limited their usefulness in machine learning applications. While text-based representation learning has significantly improved in recent years through advances in natural language processing, attempts to learn biomedical concept embeddings so far have been lacking. A recent family of models called knowledge graph embeddings have shown promising results on general domain knowledge graphs, and we explore their capabilities in the biomedical domain. We train several state-of-the-art knowledge graph embedding models on the SNOMED-CT knowledge graph, provide a benchmark with comparison to existing methods and in-depth discussion on best practices, and make a case for the importance of leveraging the multi-relational nature of knowledge graphs for learning biomedical knowledge representation. The embeddings, code, and materials will be made available to the communitY.