Jerome R. Busemeyer

Giuseppe Di Caro, Vahagn Kirakosyan, Alexander G. Abanov et al.

The accurate prediction of chromosomal instability from the morphology of circulating tumor cells (CTCs) enables real-time detection of CTCs with high metastatic potential in the context of liquid biopsy diagnostics. However, it presents a significant challenge due to the high dimensionality and complexity of single-cell digital pathology data. Here, we introduce the application of Quantum Cognition Machine Learning (QCML), a quantum-inspired computational framework, to estimate morphology-predicted chromosomal instability in CTCs from patients with metastatic breast cancer. QCML leverages quantum mechanical principles to represent data as state vectors in a Hilbert space, enabling context-aware feature modeling, dimensionality reduction, and enhanced generalization without requiring curated feature selection. QCML outperforms conventional machine learning methods when tested on out of sample verification CTCs, achieving higher accuracy in identifying predicted large-scale state transitions (pLST) status from CTC-derived morphology features. These preliminary findings support the application of QCML as a novel machine learning tool with superior performance in high-dimensional, low-sample-size biomedical contexts. QCML enables the simulation of cognition-like learning for the identification of biologically meaningful prediction of chromosomal instability from CTC morphology, offering a novel tool for CTC classification in liquid biopsy.

Alexander G. Abanov, Luca Candelori, Harold C. Steinacker et al.

We demonstrate how Quantum Cognition Machine Learning (QCML) encodes data as quantum geometry. In QCML, features of the data are represented by learned Hermitian matrices, and data points are mapped to states in Hilbert space. The quantum geometry description endows the dataset with rich geometric and topological structure - including intrinsic dimension, quantum metric, and Berry curvature - derived directly from the data. QCML captures global properties of data, while avoiding the curse of dimensionality inherent in local methods. We illustrate this on a number of synthetic and real-world examples. Quantum geometric representation of QCML could advance our understanding of cognitive phenomena within the framework of quantum cognition.

Jerome R. Busemeyer, Peter D. Kvam, Timothy J. Pleskac

Two different dynamic models for belief change during evidence monitoring were evaluated: Markov and quantum. They were empirically tested with an experiment in which participants monitored evidence for an initial period of time, made a probability rating, then monitored more evidence, before making a second rating. The models were qualitatively tested by manipulating the time intervals in a manner that provided a test for interference effects of the first rating on the second. The Markov model predicted no interference whereas the quantum model predicted interference. A quantitative comparison of the two models was also carried out using a generalization criterion method: the parameters were fit to data from one set of time intervals, and then these same parameters were used to predict data from another set of time intervals. The results indicated that some features of both Markov and quantum models are needed to accurately account for the results.