Shulin Zhao

Jean Ogier du Terrail, Quentin Klopfenstein, Honghao Li et al.

External control arms can inform early clinical development of experimental drugs and provide efficacy evidence for regulatory approval. However, accessing sufficient real-world or historical clinical trials data is challenging. Indeed, regulations protecting patients' rights by strictly controlling data processing make pooling data from multiple sources in a central server often difficult. To address these limitations, we develop a method that leverages federated learning to enable inverse probability of treatment weighting for time-to-event outcomes on separate cohorts without needing to pool data. To showcase its potential, we apply it in different settings of increasing complexity, culminating with a real-world use-case in which our method is used to compare the treatment effect of two approved chemotherapy regimens using data from three separate cohorts of patients with metastatic pancreatic cancer. By sharing our code, we hope it will foster the creation of federated research networks and thus accelerate drug development.

Michael Norris, Berkay Celik, Patrick McDaniel et al.

IoT devices are decentralized and deployed in un-stable environments, which causes them to be prone to various kinds of faults, such as device failure and network disruption. Yet, current IoT platforms require programmers to handle faults manually, a complex and error-prone task. In this paper, we present IoTRepair, a fault-handling system for IoT that (1)integrates a fault identification module to track faulty devices,(2) provides a library of fault-handling functions for effectively handling different fault types, (3) provides a fault handler on top of the library for autonomous IoT fault handling, with user and developer configuration as input. Through an evaluation in a simulated lab environment and with various fault injectio nmethods,IoTRepair is compared with current fault-handling solutions. The fault handler reduces the incorrect states on average 50.01%, which corresponds to less unsafe and insecure device states. Overall, through a systematic design of an IoT fault handler, we provide users flexibility and convenience in handling complex IoT fault handling, allowing safer IoT environments.