Zhaoyang Xu

Xiaohua Jiang, Yihao Guo, Jian Huang et al.

The precise spatial and quantitative delineation of indistinct-boundary medical objects is paramount for the accuracy of diagnostic protocols, efficacy of surgical interventions, and reliability of postoperative assessments. Despite their significance, the effective segmentation and instantaneous three-dimensional reconstruction are significantly impeded by the paucity of representative samples in available datasets and noise artifacts. To surmount these challenges, we introduced Stochastic Defect Injection (SDi) to augment the representational diversity of challenging indistinct-boundary objects within training corpora. Consequently, we propose the Dual-Encoder Fourier Group Harmonics Network (DEFN) to tailor noise filtration, amplify detailed feature recognition, and bolster representation across diverse medical imaging scenarios. By incorporating Dynamic Weight Composing (DWC) loss dynamically adjusts model's focus based on training progression, DEFN achieves SOTA performance on the OIMHS public dataset, showcasing effectiveness in indistinct boundary contexts. Source code for DEFN is available at: https://github.com/IMOP-lab/DEFN-pytorch.

Tom Gunter, Zirui Wang, Chong Wang et al.

We present foundation language models developed to power Apple Intelligence features, including a ~3 billion parameter model designed to run efficiently on devices and a large server-based language model designed for Private Cloud Compute. These models are designed to perform a wide range of tasks efficiently, accurately, and responsibly. This report describes the model architecture, the data used to train the model, the training process, how the models are optimized for inference, and the evaluation results. We highlight our focus on Responsible AI and how the principles are applied throughout the model development.

Xinhao Zhong, Shuoyang Sun, Xulin Gu et al.

Dataset distillation provides an effective approach to reduce memory and computational costs by optimizing a compact dataset that achieves performance comparable to the full original. However, for large-scale datasets and complex deep networks (e.g., ImageNet-1K with ResNet-101), the vast optimization space hinders distillation effectiveness, limiting practical applications. Recent methods leverage pre-trained diffusion models to directly generate informative images, thereby bypassing pixel-level optimization and achieving promising results. Nonetheless, these approaches often suffer from distribution shifts between the pre-trained diffusion prior and target datasets, as well as the need for multiple distillation steps under varying settings. To overcome these challenges, we propose a novel framework that is orthogonal to existing diffusion-based distillation techniques by utilizing the diffusion prior for patch selection rather than generation. Our method predicts noise from the diffusion model conditioned on input images and optional text prompts (with or without label information), and computes the associated loss for each image-patch pair. Based on the loss differences, we identify distinctive regions within the original images. Furthermore, we apply intra-class clustering and ranking on the selected patches to enforce diversity constraints. This streamlined pipeline enables a one-step distillation process. Extensive experiments demonstrate that our approach consistently outperforms state-of-the-art methods across various metrics and settings.

Ethan Li, Anders Boesen Lindbo Larsen, Chen Zhang et al. · apple-ml, cmu

We introduce two multilingual, multimodal foundation language models that power Apple Intelligence features across Apple devices and services: i a 3B-parameter on-device model optimized for Apple silicon through architectural innovations such as KV-cache sharing and 2-bit quantization-aware training; and ii a scalable server model built on a novel Parallel-Track Mixture-of-Experts PT-MoE transformer that combines track parallelism, mixture-of-experts sparse computation, and interleaved global-local attention to deliver high quality with competitive cost on Apple's Private Cloud Compute platform. Both models are trained on large-scale multilingual and multimodal datasets sourced via responsible web crawling, licensed corpora, and high-quality synthetic data, then further refined with supervised fine-tuning and reinforcement learning on a new asynchronous platform. The resulting models support several additional languages while understanding images and executing tool calls. In public benchmarks and human evaluations, both the server model and the on-device model match or surpass comparably sized open baselines. A new Swift-centric Foundation Models framework exposes guided generation, constrained tool calling, and LoRA adapter fine-tuning, allowing developers to integrate these capabilities with a few lines of code. The latest advancements in Apple Intelligence models are grounded in our Responsible AI approach with safeguards like content filtering and locale-specific evaluation, as well as our commitment to protecting our users' privacy with innovations like Private Cloud Compute.

Zhaoyang Xu, Yunbo Liu

Identifying suitable machine learning paradigms for intrusion detection remains critical for building effective and generalizable security solutions. In this study, we present a controlled comparison of four representative models - Multi-Layer Perceptron (MLP), 1D Convolutional Neural Network (CNN), One-Class Support Vector Machine (OCSVM) and Local Outlier Factor (LOF) - on the CICIDS2017 dataset under two scenarios: detecting known attack types and generalizing to previously unseen threats. Our results show that supervised MLP and CNN achieve near-perfect accuracy on familiar attacks but suffer drastic recall drops on novel attacks. Unsupervised LOF attains moderate overall accuracy and high recall on unknown threats at the cost of elevated false alarms, while boundary-based OCSVM balances precision and recall best, demonstrating robust detection across both scenarios. These findings offer practical guidance for selecting IDS models in dynamic network environments.

Ellery Wulczyn, David F. Steiner, Zhaoyang Xu et al.

Prognostic information at diagnosis has important implications for cancer treatment and monitoring. Although cancer staging, histopathological assessment, molecular features, and clinical variables can provide useful prognostic insights, improving risk stratification remains an active research area. We developed a deep learning system (DLS) to predict disease specific survival across 10 cancer types from The Cancer Genome Atlas (TCGA). We used a weakly-supervised approach without pixel-level annotations, and tested three different survival loss functions. The DLS was developed using 9,086 slides from 3,664 cases and evaluated using 3,009 slides from 1,216 cases. In multivariable Cox regression analysis of the combined cohort including all 10 cancers, the DLS was significantly associated with disease specific survival (hazard ratio of 1.58, 95% CI 1.28-1.70, p<0.0001) after adjusting for cancer type, stage, age, and sex. In a per-cancer adjusted subanalysis, the DLS remained a significant predictor of survival in 5 of 10 cancer types. Compared to a baseline model including stage, age, and sex, the c-index of the model demonstrated an absolute 3.7% improvement (95% CI 1.0-6.5) in the combined cohort. Additionally, our models stratified patients within individual cancer stages, particularly stage II (p=0.025) and stage III (p<0.001). By developing and evaluating prognostic models across multiple cancer types, this work represents one of the most comprehensive studies exploring the direct prediction of clinical outcomes using deep learning and histopathology images. Our analysis demonstrates the potential for this approach to provide prognostic information in multiple cancer types, and even within specific pathologic stages. However, given the relatively small number of clinical events, we observed wide confidence intervals, suggesting that future work will benefit from larger datasets.

Zhaoyang Xu, Faranak Sobhani, Carlos Fernandez Moro et al.

We present a novel neural network architecture, US-Net, for robust nuclei instance segmentation in histopathology images. The proposed framework integrates the nuclei detection and segmentation networks by sharing their outputs through the same foundation network, and thus enhancing the performance of both. The detection network takes into account the high-level semantic cues with contextual information, while the segmentation network focuses more on the low-level details like the edges. Extensive experiments reveal that our proposed framework can strengthen the performance of both branch networks in an integrated architecture and outperforms most of the state-of-the-art nuclei detection and segmentation networks.

Zhaoyang Xu, Xingru Huang, Carlos Fernández Moro et al.

Histopathological cancer diagnosis is based on visual examination of stained tissue slides. Hematoxylin and eosin (H\&E) is a standard stain routinely employed worldwide. It is easy to acquire and cost effective, but cells and tissue components show low-contrast with varying tones of dark blue and pink, which makes difficult visual assessments, digital image analysis, and quantifications. These limitations can be overcome by IHC staining of target proteins of the tissue slide. IHC provides a selective, high-contrast imaging of cells and tissue components, but their use is largely limited by a significantly more complex laboratory processing and high cost. We proposed a conditional CycleGAN (cCGAN) network to transform the H\&E stained images into IHC stained images, facilitating virtual IHC staining on the same slide. This data-driven method requires only a limited amount of labelled data but will generate pixel level segmentation results. The proposed cCGAN model improves the original network \cite{zhu_unpaired_2017} by adding category conditions and introducing two structural loss functions, which realize a multi-subdomain translation and improve the translation accuracy as well. % need to give reasons here. Experiments demonstrate that the proposed model outperforms the original method in unpaired image translation with multi-subdomains. We also explore the potential of unpaired images to image translation method applied on other histology images related tasks with different staining techniques.