Tianqiu Zhang

Chaoming Wang, Tianqiu Zhang, Sichao He et al.

Brain simulation builds dynamical models to mimic the structure and functions of the brain, while brain-inspired computing (BIC) develops intelligent systems by learning from the structure and functions of the brain. The two fields are intertwined and should share a common programming framework to facilitate each other's development. However, none of the existing software in the fields can achieve this goal, because traditional brain simulators lack differentiability for training, while existing deep learning (DL) frameworks fail to capture the biophysical realism and complexity of brain dynamics. In this paper, we introduce BrainPy, a differentiable brain simulator developed using JAX and XLA, with the aim of bridging the gap between brain simulation and BIC. BrainPy expands upon the functionalities of JAX, a powerful AI framework, by introducing complete capabilities for flexible, efficient, and scalable brain simulation. It offers a range of sparse and event-driven operators for efficient and scalable brain simulation, an abstraction for managing the intricacies of synaptic computations, a modular and flexible interface for constructing multi-scale brain models, and an object-oriented just-in-time compilation approach to handle the memory-intensive nature of brain dynamics. We showcase the efficiency and scalability of BrainPy on benchmark tasks, highlight its differentiable simulation for biologically plausible spiking models, and discuss its potential to support research at the intersection of brain simulation and BIC.

Tianqiu Zhang, Muyang Lyu, Xiao Liu et al.

Humans abstract experiences into structured representations to facilitate pattern inference and knowledge transfer. While the hippocampal-entorhinal (HPC-MEC) circuit is known to represent both spatial and conceptual spaces, the mechanisms for concurrently extracting abstract structures from continuous, high-dimensional dynamics remain poorly understood. We propose a brain-inspired hierarchical model that simultaneously infers latent transitions and constructs a predictive visual world model. Our architecture employs an inverse model for structural extraction alongside an HPC-MEC coupling model that dissociates relational structures (MEC) from integrated episodic scenes (HPC). Using primitive transformation dynamics as a benchmark, we demonstrate the model's capacity for structural abstraction. By leveraging velocity-driven path integration, the framework enables robust prediction and structural reuse across diverse contexts, thereby achieving structural generalization. This work provides a novel computational framework for understanding how brain-inspired, self-supervised learning of world models facilitates the acquisition of reusable abstract knowledge.

Tianqiu Zhang, Muyang Lyu, Yufan Zhang et al.

Latent Action Models (LAMs) enable the learning of world models from unlabeled video by inferring abstract actions between consecutive frames. However, LAMs face a fundamental trade-off between action abstraction and generation fidelity. Existing methods typically circumvent this issue by using two-stage training with pre-trained world models or by limiting predictions to optical flow. In this paper, we introduce DiLA, a novel Disentangled Latent Action world model that aims to resolve this trade-off via content-structure disentanglement. Our key insight is that disentanglement and latent action learning are co-evolving: the predictive bottleneck inherent in latent action learning serves as a driving force for disentanglement, compelling the model to distill spatial layouts into the structure pathway while offloading visual details to a separate content pathway for generation. This synergy yields a continuous, semantically structured latent action space without compromising generative quality. DiLA achieves superior results in video generation quality, action transfer, visual planning, and manifold interpretability. These findings establish DiLA as a unified framework that simultaneously achieves high-level action abstraction and high-fidelity generation, advancing the frontier of self-supervised world model learning.

Chaoming Wang, Muyang Lyu, Tianqiu Zhang et al.

We present a multi-scale differentiable brain modeling workflow utilizing BrainPy, a unique differentiable brain simulator that combines accurate brain simulation with powerful gradient-based optimization. We leverage this capability of BrainPy across different brain scales. At the single-neuron level, we implement differentiable neuron models and employ gradient methods to optimize their fit to electrophysiological data. On the network level, we incorporate connectomic data to construct biologically constrained network models. Finally, to replicate animal behavior, we train these models on cognitive tasks using gradient-based learning rules. Experiments demonstrate that our approach achieves superior performance and speed in fitting generalized leaky integrate-and-fire and Hodgkin-Huxley single neuron models. Additionally, training a biologically-informed network of excitatory and inhibitory spiking neurons on working memory tasks successfully replicates observed neural activity and synaptic weight distributions. Overall, our differentiable multi-scale simulation approach offers a promising tool to bridge neuroscience data across electrophysiological, anatomical, and behavioral scales.