Eric Brunner

Gowtham Krishnan Murugesan, Diana McCrumb, Eric Brunner et al.

Automatic segmentation of lesions in FDG-18 Whole Body (WB) PET/CT scans using deep learning models is instrumental for determining treatment response, optimizing dosimetry, and advancing theranostic applications in oncology. However, the presence of organs with elevated radiotracer uptake, such as the liver, spleen, brain, and bladder, often leads to challenges, as these regions are often misidentified as lesions by deep learning models. To address this issue, we propose a novel approach of segmenting both organs and lesions, aiming to enhance the performance of automatic lesion segmentation methods. In this study, we assessed the effectiveness of our proposed method using the AutoPET II challenge dataset, which comprises 1014 subjects. We evaluated the impact of inclusion of additional labels and data in the segmentation performance of the model. In addition to the expert-annotated lesion labels, we introduced eight additional labels for organs, including the liver, kidneys, urinary bladder, spleen, lung, brain, heart, and stomach. These labels were integrated into the dataset, and a 3D UNET model was trained within the nnUNet framework. Our results demonstrate that our method achieved the top ranking in the held-out test dataset, underscoring the potential of this approach to significantly improve lesion segmentation accuracy in FDG-18 Whole-Body PET/CT scans, ultimately benefiting cancer patients and advancing clinical practice.

Chen-Yu Liu, Leonardo Placidi, Eric Brunner et al.

We propose a Correlation-Complexity Map as a practical diagnostic tool for determining when real-world data distributions are structurally aligned with IQP-type quantum generative models. Characterized by two complementary indicators: (i) a Quantum Correlation-Likeness Indicator (QCLI), computed from the dataset's correlation-order (Walsh-Hadamard/Fourier) power spectrum aggregated by interaction order and quantified via Jensen-Shannon divergence from an i.i.d. binomial reference; and (ii) a Classical Correlation-Complexity Indicator (CCI), defined as the fraction of total correlation not captured by the optimal Chow-Liu tree approximation, normalized by total correlation. We provide theoretical support by relating QCLI to a support-mismatch mechanism, for fixed-architecture IQP families trained with an MMD objective, higher QCLI implies a smaller irreducible approximation floor. Using the map, we identify the classical turbulence data as both IQP-compatible and classically complex (high QCLI/high CCI). Guided by this placement, we use an invertible float-to-bitstring representation and a latent-parameter adaptation scheme that reuses a compact IQP circuit over a temporal sequence by learning and interpolating a low-dimensional latent trajectory. In comparative evaluations against classical models such as Restricted Boltzmann Machine (RBM) and Deep Convolutional Generative Adversarial Networks (DCGAN), the IQP approach achieves competitive distributional alignment while using substantially fewer training snapshots and a small latent block, supporting the use of QCLI/CCI as practical indicators for locating IQP-aligned domains and advancing generative quantum utility.