Lifang Wei

Ting Zhang, Jun Li, Yi Zhao et al.

Accurate segmentation of the blood vessels of the retina is an important step in clinical diagnosis of ophthalmic diseases. Many deep learning frameworks have come up for retinal blood vessels segmentation tasks. However, the complex vascular structure and uncertain pathological features make the blood vessel segmentation still very challenging. A novel U-shaped network named Multi-module Concatenation which is based on Atrous convolution and multi-kernel pooling is put forward to retinal vessels segmentation in this paper. The proposed network structure retains three layers the essential structure of U-Net, in which the atrous convolution combining the multi-kernel pooling blocks are designed to obtain more contextual information. The spatial attention module is concatenated with dense atrous convolution module and multi-kernel pooling module to form a multi-module concatenation. And different dilation rates are selected by cascading to acquire a larger receptive field in atrous convolution. Adequate comparative experiments are conducted on these public retinal datasets: DRIVE, STARE and CHASE_DB1. The results show that the proposed method is effective, especially for microvessels. The code will be put out at https://github.com/Rebeccala/MC-UNet

Jiaming Yu, Zihao Guan, Xinyue Chang et al.

Since the strong comorbid similarity in NDDs, such as attention-deficit hyperactivity disorder, can interfere with the accurate diagnosis of autism spectrum disorder (ASD), identifying unknown classes is extremely crucial and challenging from NDDs. We design a novel open set recognition framework for ASD-aided diagnosis (OpenNDD), which trains a model by combining autoencoder and adversarial reciprocal points learning to distinguish in-distribution and out-of-distribution categories as well as identify ASD accurately. Considering the strong similarities between NDDs, we present a joint scaling method by Min-Max scaling combined with Standardization (MMS) to increase the differences between classes for better distinguishing unknown NDDs. We conduct the experiments in the hybrid datasets from Autism Brain Imaging Data Exchange I (ABIDE I) and THE ADHD-200 SAMPLE (ADHD-200) with 791 samples from four sites and the results demonstrate the superiority on various metrics. Our OpenNDD achieves promising performance, where the accuracy is 77.38%, AUROC is 75.53% and the open set classification rate is as high as 59.43%.

Weikang Gu, Mingyue Han, Li Xue et al.

The accurate identification of high-quality correspondences is a prerequisite task in feature-based point cloud registration. However, it is extremely challenging to handle the fusion of local and global features due to feature redundancy and complex spatial relationships. Given that Gestalt principles provide key advantages in analyzing local and global relationships, we propose a novel Gestalt-guided Parallel Interaction Network via orthogonal geometric consistency (GPI-Net) in this paper. It utilizes Gestalt principles to facilitate complementary communication between local and global information. Specifically, we introduce an orthogonal integration strategy to optimally reduce redundant information and generate a more compact global structure for high-quality correspondences. To capture geometric features in correspondences, we leverage a Gestalt Feature Attention (GFA) block through a hybrid utilization of self-attention and cross-attention mechanisms. Furthermore, to facilitate the integration of local detail information into the global structure, we design an innovative Dual-path Multi-Granularity parallel interaction aggregation (DMG) block to promote information exchange across different granularities. Extensive experiments on various challenging tasks demonstrate the superior performance of our proposed GPI-Net in comparison to existing methods. The code will be released at https://github.com/gwk429/GPI-Net.

Xuemei Qiu, Dawei Fan, Yebin Huang et al.

Digital pathology has fundamentally altered diagnostic workflows by enabling the computational analysis of gigapixel Whole Slide Images (WSIs), yet effectively deciphering their complex tumor microenvironments remains a formidable challenge. Existing Multiple Instance Learning (MIL) frameworks typically treat Whole Slide Images as unstructured bags of patches, discarding critical morphological semantics and spatial geometry. This lack of inductive bias often leads to overfitting on background noise and fails to align visual features with high-level diagnostic knowledge. To overcome these limitations, we propose the Hierarchical Prototype-based Domain Priors (HPDP) framework, a unified multimodal approach for joint histopathology diagnosis and prognosis. HPDP mitigates the data-driven "black box" issue by introducing a Morphologically Anchored Prototype System (MAPS), which anchors learning to interpretable morphological clusters, and a Sinusoidal Positional Encoder (SPE) to explicitly model tissue architecture. Furthermore, we bridge the semantic gap via a Hierarchical Cross-Modal Alignment (HCMA) module, using Large Language Model (LLM)-generated descriptions to contextually refine visual representations. Extensive experiments across seven cancer cohorts demonstrate that HPDP consistently achieves state-of-the-art performance with superior robustness and interpretability.

Dawei Fan, Yifan Gao, Jiaming Yu et al.

Deep learning models have shown promising performance for cell nucleus segmentation in the field of pathology image analysis. However, training a robust model from multiple domains remains a great challenge for cell nucleus segmentation. Additionally, the shortcomings of background noise, highly overlapping between cell nucleus, and blurred edges often lead to poor performance. To address these challenges, we propose a novel framework termed CausalCellSegmenter, which combines Causal Inference Module (CIM) with Diversified Aggregation Convolution (DAC) techniques. The DAC module is designed which incorporates diverse downsampling features through a simple, parameter-free attention module (SimAM), aiming to overcome the problems of false-positive identification and edge blurring. Furthermore, we introduce CIM to leverage sample weighting by directly removing the spurious correlations between features for every input sample and concentrating more on the correlation between features and labels. Extensive experiments on the MoNuSeg-2018 dataset achieves promising results, outperforming other state-of-the-art methods, where the mIoU and DSC scores growing by 3.6% and 2.65%.