Afshin Beheshti

Shad Nygren, Pinar Avci, Andre Daniels et al.

Drug side effects are a major global health concern, necessitating advanced methods for their accurate detection and analysis. While Large Language Models (LLMs) offer promising conversational interfaces, their inherent limitations, including reliance on black-box training data, susceptibility to hallucinations, and lack of domain-specific knowledge, hinder their reliability in specialized fields like pharmacovigilance. To address this gap, we propose two architectures: Retrieval-Augmented Generation (RAG) and GraphRAG, which integrate comprehensive drug side effect knowledge into a Llama 3 8B language model. Through extensive evaluations on 19,520 drug side effect associations (covering 976 drugs and 3,851 side effect terms), our results demonstrate that GraphRAG achieves near-perfect accuracy in drug side effect retrieval. This framework offers a highly accurate and scalable solution, signifying a significant advancement in leveraging LLMs for critical pharmacovigilance applications.

Ryan T. Scott, Erik L. Antonsen, Lauren M. Sanders et al.

Human space exploration beyond low Earth orbit will involve missions of significant distance and duration. To effectively mitigate myriad space health hazards, paradigm shifts in data and space health systems are necessary to enable Earth-independence, rather than Earth-reliance. Promising developments in the fields of artificial intelligence and machine learning for biology and health can address these needs. We propose an appropriately autonomous and intelligent Precision Space Health system that will monitor, aggregate, and assess biomedical statuses; analyze and predict personalized adverse health outcomes; adapt and respond to newly accumulated data; and provide preventive, actionable, and timely insights to individual deep space crew members and iterative decision support to their crew medical officer. Here we present a summary of recommendations from a workshop organized by the National Aeronautics and Space Administration, on future applications of artificial intelligence in space biology and health. In the next decade, biomonitoring technology, biomarker science, spacecraft hardware, intelligent software, and streamlined data management must mature and be woven together into a Precision Space Health system to enable humanity to thrive in deep space.

Lauren M. Sanders, Jason H. Yang, Ryan T. Scott et al.

Space biology research aims to understand fundamental effects of spaceflight on organisms, develop foundational knowledge to support deep space exploration, and ultimately bioengineer spacecraft and habitats to stabilize the ecosystem of plants, crops, microbes, animals, and humans for sustained multi-planetary life. To advance these aims, the field leverages experiments, platforms, data, and model organisms from both spaceborne and ground-analog studies. As research is extended beyond low Earth orbit, experiments and platforms must be maximally autonomous, light, agile, and intelligent to expedite knowledge discovery. Here we present a summary of recommendations from a workshop organized by the National Aeronautics and Space Administration on artificial intelligence, machine learning, and modeling applications which offer key solutions toward these space biology challenges. In the next decade, the synthesis of artificial intelligence into the field of space biology will deepen the biological understanding of spaceflight effects, facilitate predictive modeling and analytics, support maximally autonomous and reproducible experiments, and efficiently manage spaceborne data and metadata, all with the goal to enable life to thrive in deep space.