Shen Zhao

Yanxin Long, Youpeng Wen, Jianhua Han et al.

Benefiting from large-scale vision-language pre-training on image-text pairs, open-world detection methods have shown superior generalization ability under the zero-shot or few-shot detection settings. However, a pre-defined category space is still required during the inference stage of existing methods and only the objects belonging to that space will be predicted. To introduce a "real" open-world detector, in this paper, we propose a novel method named CapDet to either predict under a given category list or directly generate the category of predicted bounding boxes. Specifically, we unify the open-world detection and dense caption tasks into a single yet effective framework by introducing an additional dense captioning head to generate the region-grounded captions. Besides, adding the captioning task will in turn benefit the generalization of detection performance since the captioning dataset covers more concepts. Experiment results show that by unifying the dense caption task, our CapDet has obtained significant performance improvements (e.g., +2.1% mAP on LVIS rare classes) over the baseline method on LVIS (1203 classes). Besides, our CapDet also achieves state-of-the-art performance on dense captioning tasks, e.g., 15.44% mAP on VG V1.2 and 13.98% on the VG-COCO dataset.

Bingqian Lin, Zicong Chen, Mingjie Li et al.

Medical artificial general intelligence (MAGI) enables one foundation model to solve different medical tasks, which is very practical in the medical domain. It can significantly reduce the requirement of large amounts of task-specific data by sufficiently sharing medical knowledge among different tasks. However, due to the challenges of designing strongly generalizable models with limited and complex medical data, most existing approaches tend to develop task-specific models. To take a step towards MAGI, we propose a new paradigm called Medical-knOwledge-enhanced mulTimOdal pretRaining (MOTOR). In MOTOR, we combine two kinds of basic medical knowledge, i.e., general and specific knowledge, in a complementary manner to boost the general pretraining process. As a result, the foundation model with comprehensive basic knowledge can learn compact representations from pretraining radiographic data for better cross-modal alignment. MOTOR unifies the understanding and generation, which are two kinds of core intelligence of an AI system, into a single medical foundation model, to flexibly handle more diverse medical tasks. To enable a comprehensive evaluation and facilitate further research, we construct a medical multimodal benchmark including a wide range of downstream tasks, such as chest x-ray report generation and medical visual question answering. Extensive experiments on our benchmark show that MOTOR obtains promising results through simple task-oriented adaptation. The visualization shows that the injected knowledge successfully highlights key information in the medical data, demonstrating the excellent interpretability of MOTOR. Our MOTOR successfully mimics the human practice of fulfilling a "medical student" to accelerate the process of becoming a "specialist". We believe that our work makes a significant stride in realizing MAGI.

Binbin Yang, Xinchi Deng, Han Shi et al.

Continual learning is a challenging real-world problem for constructing a mature AI system when data are provided in a streaming fashion. Despite recent progress in continual classification, the researches of continual object detection are impeded by the diverse sizes and numbers of objects in each image. Different from previous works that tune the whole network for all tasks, in this work, we present a simple and flexible framework for continual object detection via pRotOtypical taSk corrElaTion guided gaTing mechAnism (ROSETTA). Concretely, a unified framework is shared by all tasks while task-aware gates are introduced to automatically select sub-models for specific tasks. In this way, various knowledge can be successively memorized by storing their corresponding sub-model weights in this system. To make ROSETTA automatically determine which experience is available and useful, a prototypical task correlation guided Gating Diversity Controller(GDC) is introduced to adaptively adjust the diversity of gates for the new task based on class-specific prototypes. GDC module computes class-to-class correlation matrix to depict the cross-task correlation, and hereby activates more exclusive gates for the new task if a significant domain gap is observed. Comprehensive experiments on COCO-VOC, KITTI-Kitchen, class-incremental detection on VOC and sequential learning of four tasks show that ROSETTA yields state-of-the-art performance on both task-based and class-based continual object detection.

Xinchi Deng, Han Shi, Runhui Huang et al.

Cross-modal pre-training has shown impressive performance on a wide range of downstream tasks, benefiting from massive image-text pairs collected from the Internet. In practice, online data are growing constantly, highlighting the importance of the ability of pre-trained model to learn from data that is continuously growing. Existing works on cross-modal pre-training mainly focus on training a network with fixed architecture. However, it is impractical to limit the model capacity when considering the continuously growing nature of pre-training data in real-world applications. On the other hand, it is important to utilize the knowledge in the current model to obtain efficient training and better performance. To address the above issues, in this paper, we propose GrowCLIP, a data-driven automatic model growing algorithm for contrastive language-image pre-training with continuous image-text pairs as input. Specially, we adopt a dynamic growth space and seek out the optimal architecture at each growth step to adapt to online learning scenarios. And the shared encoder is proposed in our growth space to enhance the degree of cross-modal fusion. Besides, we explore the effect of growth in different dimensions, which could provide future references for the design of cross-modal model architecture. Finally, we employ parameter inheriting with momentum (PIM) to maintain the previous knowledge and address the issue of the local minimum dilemma. Compared with the existing methods, GrowCLIP improves 2.3% average top-1 accuracy on zero-shot image classification of 9 downstream tasks. As for zero-shot image retrieval, GrowCLIP can improve 1.2% for top-1 image-to-text recall on Flickr30K dataset.

Xinshun Wang, Qiongjie Cui, Chen Chen et al.

Existing Graph Convolutional Networks to achieve human motion prediction largely adopt a one-step scheme, which output the prediction straight from history input, failing to exploit human motion patterns. We observe that human motions have transitional patterns and can be split into snippets representative of each transition. Each snippet can be reconstructed from its starting and ending poses referred to as the transitional poses. We propose a snippet-to-motion multi-stage framework that breaks motion prediction into sub-tasks easier to accomplish. Each sub-task integrates three modules: transitional pose prediction, snippet reconstruction, and snippet-to-motion prediction. Specifically, we propose to first predict only the transitional poses. Then we use them to reconstruct the corresponding snippets, obtaining a close approximation to the true motion sequence. Finally we refine them to produce the final prediction output. To implement the network, we propose a novel unified graph modeling, which allows for direct and effective feature propagation compared to existing approaches which rely on separate space-time modeling. Extensive experiments on Human 3.6M, CMU Mocap and 3DPW datasets verify the effectiveness of our method which achieves state-of-the-art performance.

Kanghao Chen, Weixian Lei, Rong Zhang et al.

Imbalanced training data is a significant challenge for medical image classification. In this study, we propose a novel Progressive Class-Center Triplet (PCCT) framework to alleviate the class imbalance issue particularly for diagnosis of rare diseases, mainly by carefully designing the triplet sampling strategy and the triplet loss formation. Specifically, the PCCT framework includes two successive stages. In the first stage, PCCT trains the diagnosis system via a class-balanced triplet loss to coarsely separate distributions of different classes. In the second stage, the PCCT framework further improves the diagnosis system via a class-center involved triplet loss to cause a more compact distribution for each class. For the class-balanced triplet loss, triplets are sampled equally for each class at each training iteration, thus alleviating the imbalanced data issue. For the class-center involved triplet loss, the positive and negative samples in each triplet are replaced by their corresponding class centers, which enforces data representations of the same class closer to the class center. Furthermore, the class-center involved triplet loss is extended to the pair-wise ranking loss and the quadruplet loss, which demonstrates the generalization of the proposed framework. Extensive experiments support that the PCCT framework works effectively for medical image classification with imbalanced training images. On two skin image datasets and one chest X-ray dataset, the proposed approach respectively obtains the mean F1 score 86.2, 65.2, and 90.66 over all classes and 81.4, 63.87, and 81.92 for rare classes, achieving state-of-the-art performance and outperforming the widely used methods for the class imbalance issue.

Jiahui Gong, Jingtao Ding, Fanjin Meng et al.

Mobile devices, especially smartphones, can support rich functions and have developed into indispensable tools in daily life. With the rise of generative AI services, smartphones can potentially transform into personalized assistants, anticipating user needs and scheduling services accordingly. Predicting user intents on smartphones, and reflecting anticipated activities based on past interactions and context, remains a pivotal step towards this vision. Existing research predominantly focuses on specific domains, neglecting the challenge of modeling diverse event sequences across dynamic contexts. Leveraging pre-trained language models (PLMs) offers a promising avenue, yet adapting PLMs to on-device user intent prediction presents significant challenges. To address these challenges, we propose PITuning, a Population-to-Individual Tuning framework. PITuning enhances common pattern extraction through dynamic event-to-intent transition modeling and addresses long-tailed preferences via adaptive unlearning strategies. Experimental results on real-world datasets demonstrate PITuning's superior intent prediction performance, highlighting its ability to capture long-tailed preferences and its practicality for on-device prediction scenarios.

Xinshun Wang, Qiongjie Cui, Chen Chen et al.

In recent years, Graph Convolutional Networks (GCNs) have been widely used in human motion prediction, but their performance remains unsatisfactory. Recently, MLP-Mixer, initially developed for vision tasks, has been leveraged into human motion prediction as a promising alternative to GCNs, which achieves both better performance and better efficiency than GCNs. Unlike GCNs, which can explicitly capture human skeleton's bone-joint structure by representing it as a graph with edges and nodes, MLP-Mixer relies on fully connected layers and thus cannot explicitly model such graph-like structure of human's. To break this limitation of MLP-Mixer's, we propose \textit{Graph-Guided Mixer}, a novel approach that equips the original MLP-Mixer architecture with the capability to model graph structure. By incorporating graph guidance, our \textit{Graph-Guided Mixer} can effectively capture and utilize the specific connectivity patterns within human skeleton's graph representation. In this paper, first we uncover a theoretical connection between MLP-Mixer and GCN that is unexplored in existing research. Building on this theoretical connection, next we present our proposed \textit{Graph-Guided Mixer}, explaining how the original MLP-Mixer architecture is reinvented to incorporate guidance from graph structure. Then we conduct an extensive evaluation on the Human3.6M, AMASS, and 3DPW datasets, which shows that our method achieves state-of-the-art performance.

Wanying Zhang, Shen Zhao, Fanyang Meng et al.

With potential applications in fields including intelligent surveillance and human-robot interaction, the human motion prediction task has become a hot research topic and also has achieved high success, especially using the recent Graph Convolutional Network (GCN). Current human motion prediction task usually focuses on predicting human motions for atomic actions. Observing that atomic actions can happen at the same time and thus formulating the composite actions, we propose the composite human motion prediction task. To handle this task, we first present a Composite Action Generation (CAG) module to generate synthetic composite actions for training, thus avoiding the laborious work of collecting composite action samples. Moreover, we alleviate the effect of composite actions on demand for a more complicated model by presenting a Dynamic Compositional Graph Convolutional Network (DC-GCN). Extensive experiments on the Human3.6M dataset and our newly collected CHAMP dataset consistently verify the efficiency of our DC-GCN method, which achieves state-of-the-art motion prediction accuracies and meanwhile needs few extra computational costs than traditional GCN-based human motion methods.

Zixuan Tang, Shen Zhao

Fine-grained medical image classification is challenged by subtle inter-class variations and visually ambiguous cases, where confidence estimates often exhibit uncertainty rather than being overconfident. In such scenarios, purely discriminative classifiers may achieve high overall accuracy yet still fail to distinguish between highly similar categories, leading to miscalibrated predictions. We propose T-DuMpRa, a teacher-guided dual-path multi-prototype retrieval-augmented framework, where discriminative classification and multi-prototype retrieval jointly drive both training and prediction. During training, we jointly optimize cross-entropy and supervised contrastive objectives to learn a cosine-compatible embedding geometry for reliable prototype matching. We further employ an exponential moving average (EMA) teacher to obtain smoother representations and build a multi-prototype memory bank by clustering teacher embeddings in the teacher embedding space. Our framework is plug-and-play: it can be easily integrated into existing classification models by constructing a compact prototype bank, thereby improving performance on visually ambiguous cases. At inference, we combine the classifier's predicted distribution with a similarity-based distribution computed via cosine matching to prototypes, and apply a conservative confidence-gated fusion that activates retrieval only when the classifier's prediction is uncertain and the retrieval evidence is decisive and conflicting, otherwise keeping confident predictions unchanged. On HAM10000 and ISIC2019, our method yields 0.68%-0.21% and 0.44%-2.69% improvements on 5 different backbones. And visualization analysis proves our model can enhance the model's ability to handle visually ambiguous cases.

Jinfu Liu, Runwei Ding, Yuhang Wen et al.

Multimodal-based action recognition methods have achieved high success using pose and RGB modality. However, skeletons sequences lack appearance depiction and RGB images suffer irrelevant noise due to modality limitations. To address this, we introduce human parsing feature map as a novel modality, since it can selectively retain effective semantic features of the body parts, while filtering out most irrelevant noise. We propose a new dual-branch framework called Ensemble Human Parsing and Pose Network (EPP-Net), which is the first to leverage both skeletons and human parsing modalities for action recognition. The first human pose branch feeds robust skeletons in graph convolutional network to model pose features, while the second human parsing branch also leverages depictive parsing feature maps to model parsing festures via convolutional backbones. The two high-level features will be effectively combined through a late fusion strategy for better action recognition. Extensive experiments on NTU RGB+D and NTU RGB+D 120 benchmarks consistently verify the effectiveness of our proposed EPP-Net, which outperforms the existing action recognition methods. Our code is available at: https://github.com/liujf69/EPP-Net-Action.

Ruicheng Zhang, Haowei Guo, Zeyu Zhang et al.

Multi-organ segmentation is a critical yet challenging task due to complex anatomical backgrounds, blurred boundaries, and diverse morphologies. This study introduces the Gradient-aware Adaptive Momentum Evolution Deep Snake (GAMED-Snake) model, which establishes a novel paradigm for contour-based segmentation by integrating gradient-based learning with adaptive momentum evolution mechanisms. The GAMED-Snake model incorporates three major innovations: First, the Distance Energy Map Prior (DEMP) generates a pixel-level force field that effectively attracts contour points towards the true boundaries, even in scenarios with complex backgrounds and blurred edges. Second, the Differential Convolution Inception Module (DCIM) precisely extracts comprehensive energy gradients, significantly enhancing segmentation accuracy. Third, the Adaptive Momentum Evolution Mechanism (AMEM) employs cross-attention to establish dynamic features across different iterations of evolution, enabling precise boundary alignment for diverse morphologies. Experimental results on four challenging multi-organ segmentation datasets demonstrate that GAMED-Snake improves the mDice metric by approximately 2% compared to state-of-the-art methods. Code will be available at https://github.com/SYSUzrc/GAMED-Snake.

Zhichao Deng, Xiangtai Li, Xia Li et al.

Understanding the real world through point cloud video is a crucial aspect of robotics and autonomous driving systems. However, prevailing methods for 4D point cloud recognition have limitations due to sensor resolution, which leads to a lack of detailed information. Recent advances have shown that Vision-Language Models (VLM) pre-trained on web-scale text-image datasets can learn fine-grained visual concepts that can be transferred to various downstream tasks. However, effectively integrating VLM into the domain of 4D point clouds remains an unresolved problem. In this work, we propose the Vision-Language Models Goes 4D (VG4D) framework to transfer VLM knowledge from visual-text pre-trained models to a 4D point cloud network. Our approach involves aligning the 4D encoder's representation with a VLM to learn a shared visual and text space from training on large-scale image-text pairs. By transferring the knowledge of the VLM to the 4D encoder and combining the VLM, our VG4D achieves improved recognition performance. To enhance the 4D encoder, we modernize the classic dynamic point cloud backbone and propose an improved version of PSTNet, im-PSTNet, which can efficiently model point cloud videos. Experiments demonstrate that our method achieves state-of-the-art performance for action recognition on both the NTU RGB+D 60 dataset and the NTU RGB+D 120 dataset. Code is available at \url{https://github.com/Shark0-0/VG4D}.

Yixin Zhang, Shen Zhao, Hanxue Gu et al.

Deep neural networks (DNNs) have demonstrated exceptional performance across various image segmentation tasks. However, the process of preparing datasets for training segmentation DNNs is both labor-intensive and costly, as it typically requires pixel-level annotations for each object of interest. To mitigate this challenge, alternative approaches such as using weak labels (e.g., bounding boxes or scribbles) or less precise (noisy) annotations can be employed. Noisy and weak labels are significantly quicker to generate, allowing for more annotated images within the same time frame. However, the potential decrease in annotation quality may adversely impact the segmentation performance of the resulting model. In this study, we conducted a comprehensive cost-effectiveness evaluation on six variants of annotation strategies (9~10 sub-variants in total) across 4 datasets and conclude that the common practice of precisely outlining objects of interest is virtually never the optimal approach when annotation budget is limited. Both noisy and weak annotations showed usage cases that yield similar performance to the perfectly annotated counterpart, yet had significantly better cost-effectiveness. We hope our findings will help researchers be aware of the different available options and use their annotation budgets more efficiently, especially in cases where accurately acquiring labels for target objects is particularly costly. Our code will be made available on https://github.com/yzluka/AnnotationEfficiency2D.

Kaidong Zhang, Jian Zhang, Rongtao Xu et al.

Vision--Language--Action (VLA) models have emerged as a powerful paradigm for open-world robot manipulation, but their practical deployment is often constrained by \emph{cost}: billion-scale VLM backbones and iterative diffusion/flow-based action heads incur high latency and compute, making real-time control expensive on commodity hardware. We present A1, a fully open-source and transparent VLA framework designed for low-cost, high-throughput inference without sacrificing manipulation success; Our approach leverages pretrained VLMs that provide implicit affordance priors for action generation. We release the full training stack (training code, data/data-processing pipeline, intermediate checkpoints, and evaluation scripts) to enable end-to-end reproducibility. Beyond optimizing the VLM alone, A1 targets the full inference pipeline by introducing a budget-aware adaptive inference scheme that jointly accelerates the backbone and the \emph{action head}. Specifically, we monitor action consistency across intermediate VLM layers to trigger early termination, and propose Inter-Layer Truncated Flow Matching that warm-starts denoising across layers, enabling accurate actions with substantially fewer effective denoising iterations. Across simulation benchmarks (LIBERO, VLABench) and real robots (Franka, AgiBot), A1 achieves state-of-the-art success rates while significantly reducing inference cost (e.g., up to 72% lower per-episode latency for flow-matching inference and up to 76.6% backbone computation reduction with minor performance degradation). On RoboChallenge, A1 achieves an average success rate of 29.00%, outperforming baselines including pi0(28.33%), X-VLA (21.33%), and RDT-1B (15.00%).

Liangrui Pan, Qingchun Liang, Shen Zhao et al.

Accurately predicting gene mutations, mutation subtypes and their exons in lung cancer is critical for personalized treatment planning and prognostic assessment. Faced with regional disparities in medical resources and the high cost of genomic assays, using artificial intelligence to infer these mutations and exon variants from routine histopathology images could greatly facilitate precision therapy. Although some prior studies have shown that deep learning can accelerate the prediction of key gene mutations from lung cancer pathology slides, their performance remains suboptimal and has so far been limited mainly to early screening tasks. To address these limitations, we have assembled PathGene, which comprises histopathology images paired with next-generation sequencing reports from 1,576 patients at the Second Xiangya Hospital, Central South University, and 448 TCGA-LUAD patients. This multi-center dataset links whole-slide images to driver gene mutation status, mutation subtypes, exon, and tumor mutational burden (TMB) status, with the goal of leveraging pathology images to predict mutations, subtypes, exon locations, and TMB for early genetic screening and to advance precision oncology. Unlike existing datasets, we provide molecular-level information related to histopathology images in PathGene to facilitate the development of biomarker prediction models. We benchmarked 11 multiple-instance learning methods on PathGene for mutation, subtype, exon, and TMB prediction tasks. These experimental methods provide valuable alternatives for early genetic screening of lung cancer patients and assisting clinicians to quickly develop personalized precision targeted treatment plans for patients. Code and data are available at https://github.com/panliangrui/NIPS2025/.

Youpeng Wen, Junfan Lin, Yi Zhu et al.

Recent advancements utilizing large-scale video data for learning video generation models demonstrate significant potential in understanding complex physical dynamics. It suggests the feasibility of leveraging diverse robot trajectory data to develop a unified, dynamics-aware model to enhance robot manipulation. However, given the relatively small amount of available robot data, directly fitting data without considering the relationship between visual observations and actions could lead to suboptimal data utilization. To this end, we propose VidMan (Video Diffusion for Robot Manipulation), a novel framework that employs a two-stage training mechanism inspired by dual-process theory from neuroscience to enhance stability and improve data utilization efficiency. Specifically, in the first stage, VidMan is pre-trained on the Open X-Embodiment dataset (OXE) for predicting future visual trajectories in a video denoising diffusion manner, enabling the model to develop a long horizontal awareness of the environment's dynamics. In the second stage, a flexible yet effective layer-wise self-attention adapter is introduced to transform VidMan into an efficient inverse dynamics model that predicts action modulated by the implicit dynamics knowledge via parameter sharing. Our VidMan framework outperforms state-of-the-art baseline model GR-1 on the CALVIN benchmark, achieving a 11.7% relative improvement, and demonstrates over 9% precision gains on the OXE small-scale dataset. These results provide compelling evidence that world models can significantly enhance the precision of robot action prediction. Codes and models will be public.

Shidan He, Lei Liu, Xiujun Shu et al.

Anomaly synthesis is a crucial approach to augment abnormal data for advancing anomaly inspection. Based on the knowledge from the large-scale pre-training, existing text-to-image anomaly synthesis methods predominantly focus on textual information or coarse-aligned visual features to guide the entire generation process. However, these methods often lack sufficient descriptors to capture the complicated characteristics of realistic anomalies (e.g., the fine-grained visual pattern of anomalies), limiting the realism and generalization of the generation process. To this end, we propose a novel anomaly synthesis framework called AnomalyControl to learn cross-modal semantic features as guidance signals, which could encode the generalized anomaly cues from text-image reference prompts and improve the realism of synthesized abnormal samples. Specifically, AnomalyControl adopts a flexible and non-matching prompt pair (i.e., a text-image reference prompt and a targeted text prompt), where a Cross-modal Semantic Modeling (CSM) module is designed to extract cross-modal semantic features from the textual and visual descriptors. Then, an Anomaly-Semantic Enhanced Attention (ASEA) mechanism is formulated to allow CSM to focus on the specific visual patterns of the anomaly, thus enhancing the realism and contextual relevance of the generated anomaly features. Treating cross-modal semantic features as the prior, a Semantic Guided Adapter (SGA) is designed to encode effective guidance signals for the adequate and controllable synthesis process. Extensive experiments indicate that AnomalyControl can achieve state-of-the-art results in anomaly synthesis compared with existing methods while exhibiting superior performance for downstream tasks.

Zixuan Tang, Shen Zhao

Large segmentation foundation models such as the Segment Anything Model (SAM) have reshaped promptable segmentation in natural images, and recent efforts have extended these models to medical images and volumetric settings. However, directly transferring a 3D SAM-style model to lesion segmentation remains challenging due to (i) weak spatial representational capacity for small, irregular targets in intermediate features, and (ii) extreme foreground-background imbalance in 3D volumes.We propose SGP-SAM, a self-gated prompting framework for efficient and effective transfer to 3D lesion segmentation. Our key component, the Self-Gated Prompting Module (SGPM), performs conditional multi-scale spatial enhancement: a lightweight multi-channel gating unit predicts whether the current features require additional multi-scale fusion, and only then activates a Multi-Scale Feature Fusion Block to enrich spatial context. To further address small-lesion learning, we design a Zoom Loss that up-weights lesion-focused supervision by combining Dice and a voxel-balanced focal term.Experiments on MSD Liver Tumor and MSD Brain Tumor (enhancing tumor) show consistent gains over strong transfer baselines based on SAM-Med3D. On MSD Liver Tumor, SGP-SAM improves mDice by 7.3% over fine-tuning.

Ruicheng Zhang, Haowei Guo, Kanghui Tian et al.

Unified Medical Image Segmentation (UMIS) is critical for comprehensive anatomical assessment but faces challenges due to multi-scale structural heterogeneity. Conventional pixel-based approaches, lacking object-level anatomical insight and inter-organ relational modeling, struggle with morphological complexity and feature conflicts, limiting their efficacy in UMIS. We propose Mamba Snake, a novel deep snake framework enhanced by state space modeling for UMIS. Mamba Snake frames multi-contour evolution as a hierarchical state space atlas, effectively modeling macroscopic inter-organ topological relationships and microscopic contour refinements. We introduce a snake-specific vision state space module, the Mamba Evolution Block (MEB), which leverages effective spatiotemporal information aggregation for adaptive refinement of complex morphologies. Energy map shape priors further ensure robust long-range contour evolution in heterogeneous data. Additionally, a dual-classification synergy mechanism is incorporated to concurrently optimize detection and segmentation, mitigating under-segmentation of microstructures in UMIS. Extensive evaluations across five clinical datasets reveal Mamba Snake's superior performance, with an average Dice improvement of 3\% over state-of-the-art methods.

Sheng Lian, Dengfeng Pan, Jianlong Cai et al.

Accurate lumbar spine segmentation is crucial for diagnosing spinal disorders. Existing methods typically use coarse-grained segmentation strategies that lack the fine detail needed for precise diagnosis. Additionally, their reliance on visual-only models hinders the capture of anatomical semantics, leading to misclassified categories and poor segmentation details. To address these limitations, we present ATM-Net, an innovative framework that employs an anatomy-aware, text-guided, multi-modal fusion mechanism for fine-grained segmentation of lumbar substructures, i.e., vertebrae (VBs), intervertebral discs (IDs), and spinal canal (SC). ATM-Net adopts the Anatomy-aware Text Prompt Generator (ATPG) to adaptively convert image annotations into anatomy-aware prompts in different views. These insights are further integrated with image features via the Holistic Anatomy-aware Semantic Fusion (HASF) module, building a comprehensive anatomical context. The Channel-wise Contrastive Anatomy-Aware Enhancement (CCAE) module further enhances class discrimination and refines segmentation through class-wise channel-level multi-modal contrastive learning. Extensive experiments on the MRSpineSeg and SPIDER datasets demonstrate that ATM-Net significantly outperforms state-of-the-art methods, with consistent improvements regarding class discrimination and segmentation details. For example, ATM-Net achieves Dice of 79.39% and HD95 of 9.91 pixels on SPIDER, outperforming the competitive SpineParseNet by 8.31% and 4.14 pixels, respectively.

Gexin Huang, Chenfei Wu, Mingjie Li et al.

Predicting genetic mutations from whole slide images is indispensable for cancer diagnosis. However, existing work training multiple binary classification models faces two challenges: (a) Training multiple binary classifiers is inefficient and would inevitably lead to a class imbalance problem. (b) The biological relationships among genes are overlooked, which limits the prediction performance. To tackle these challenges, we innovatively design a Biological-knowledge enhanced PathGenomic multi-label Transformer to improve genetic mutation prediction performances. BPGT first establishes a novel gene encoder that constructs gene priors by two carefully designed modules: (a) A gene graph whose node features are the genes' linguistic descriptions and the cancer phenotype, with edges modeled by genes' pathway associations and mutation consistencies. (b) A knowledge association module that fuses linguistic and biomedical knowledge into gene priors by transformer-based graph representation learning, capturing the intrinsic relationships between different genes' mutations. BPGT then designs a label decoder that finally performs genetic mutation prediction by two tailored modules: (a) A modality fusion module that firstly fuses the gene priors with critical regions in WSIs and obtains gene-wise mutation logits. (b) A comparative multi-label loss that emphasizes the inherent comparisons among mutation status to enhance the discrimination capabilities. Sufficient experiments on The Cancer Genome Atlas benchmark demonstrate that BPGT outperforms the state-of-the-art.

Zhongbin Fang, Xia Li, Xiangtai Li et al.

Recently, 3D point cloud classification has made significant progress with the help of many datasets. However, these datasets do not reflect the incomplete nature of real-world point clouds caused by occlusion, which limits the practical application of current methods. To bridge this gap, we propose ModelNet-O, a large-scale synthetic dataset of 123,041 samples that emulate real-world point clouds with self-occlusion caused by scanning from monocular cameras. ModelNet-O is 10 times larger than existing datasets and offers more challenging cases to evaluate the robustness of existing methods. Our observation on ModelNet-O reveals that well-designed sparse structures can preserve structural information of point clouds under occlusion, motivating us to propose a robust point cloud processing method that leverages a critical point sampling (CPS) strategy in a multi-level manner. We term our method PointMLS. Through extensive experiments, we demonstrate that our PointMLS achieves state-of-the-art results on ModelNet-O and competitive results on regular datasets, and it is robust and effective. More experiments also demonstrate the robustness and effectiveness of PointMLS.

Chenchu Xu, Lei Xu, Zhifan Gao et al.

Accurate detection of the myocardial infarction (MI) area is crucial for early diagnosis planning and follow-up management. In this study, we propose an end-to-end deep-learning algorithm framework (OF-RNN ) to accurately detect the MI area at the pixel level. Our OF-RNN consists of three different function layers: the heart localization layers, which can accurately and automatically crop the region-of-interest (ROI) sequences, including the left ventricle, using the whole cardiac magnetic resonance image sequences; the motion statistical layers, which are used to build a time-series architecture to capture two types of motion features (at the pixel-level) by integrating the local motion features generated by long short-term memory-recurrent neural networks and the global motion features generated by deep optical flows from the whole ROI sequence, which can effectively characterize myocardial physiologic function; and the fully connected discriminate layers, which use stacked auto-encoders to further learn these features, and they use a softmax classifier to build the correspondences from the motion features to the tissue identities (infarction or not) for each pixel. Through the seamless connection of each layer, our OF-RNN can obtain the area, position, and shape of the MI for each patient. Our proposed framework yielded an overall classification accuracy of 94.35% at the pixel level, from 114 clinical subjects. These results indicate the potential of our proposed method in aiding standardized MI assessments.