Yuanyuan Sun

Alexander K. Saeri, Jess Graham, Michael Noetel et al.

Artificial intelligence poses many risks, ranging from familiar present-day harms to unprecedented and potentially catastrophic ones. Effective risk management requires prioritization: we must understand which risks are most severe, who is most vulnerable, and who is most responsible for addressing them. We report results from a three-round Delphi study conducted late 2025 with 272 international AI experts. Experts rated 24 AI risks on harm probability and severity, sector and actor vulnerability, actor responsibility, and overall concern. Experts estimated the five most severe harms in the next 5 years were likely to come from dangerous capabilities, competitive dynamics, weapons & cyberattacks (including CBRNE), power centralization, and false information. In a business-as-usual scenario, experts judged 18 of 24 risks as having a more than 10% probability of catastrophic outcomes (e.g., more than 1 million deaths or more than USD 100B in financial loss) in the next 5 years (2025-2030). In a scenario where pragmatic mitigations are implemented, experts still judged five risks as having a more than 10% probability of catastrophic outcomes: dangerous capabilities, weapons & cyberattacks, environmental harm, inequality & unemployment, and power centralization. All 24 risks were judged as being more than 5% likely to cause catastrophic outcomes. AI users and the general public were judged the most vulnerable to these risks, but experts assigned the highest responsibility for addressing them to general-purpose AI developers and governance actors (including governments, regulators, and standards bodies). Across most risks, experts identified information, finance, and national security as the most vulnerable sectors. These findings can guide AI risk prioritization and clarify expert expectations about who should bear responsibility for mitigation.

Ling Luo, Jinzhong Ning, Yingwen Zhao et al.

Objective: Most existing fine-tuned biomedical large language models (LLMs) focus on enhancing performance in monolingual biomedical question answering and conversation tasks. To investigate the effectiveness of the fine-tuned LLMs on diverse biomedical NLP tasks in different languages, We present Taiyi, a bilingual fine-tuned LLM for diverse biomedical tasks. Materials and Methods: We first curated a comprehensive collection of 140 existing biomedical text mining datasets (102 English and 38 Chinese datasets) across over 10 task types. Subsequently, a two-stage strategy is proposed for supervised fine-tuning to optimize the model performance across varied tasks. Results: Experimental results on 13 test sets covering named entity recognition, relation extraction, text classification, question answering tasks demonstrate that Taiyi achieves superior performance compared to general LLMs. The case study involving additional biomedical NLP tasks further shows Taiyi's considerable potential for bilingual biomedical multi-tasking. Conclusion: Leveraging rich high-quality biomedical corpora and developing effective fine-tuning strategies can significantly improve the performance of LLMs within the biomedical domain. Taiyi shows the bilingual multi-tasking capability through supervised fine-tuning. However, those tasks such as information extraction that are not generation tasks in nature remain challenging for LLM-based generative approaches, and they still underperform the conventional discriminative approaches of smaller language models.

Yahui Li, Yang Li, Yuanyuan Sun

As one important means of ensuring secure operation in a power system, the contingency selection and ranking methods need to be more rapid and accurate. A novel method-based least absolute shrinkage and selection operator (Lasso) algorithm is proposed in this paper to apply to online static security assessment (OSSA). The assessment is based on a security index, which is applied to select and screen contingencies. Firstly, the multi-step adaptive Lasso (MSA-Lasso) regression algorithm is introduced based on the regression algorithm, whose predictive performance has an advantage. Then, an OSSA module is proposed to evaluate and select contingencies in different load conditions. In addition, the Lasso algorithm is employed to predict the security index of each power system operation state with the consideration of bus voltages and power flows, according to Newton-Raphson load flow (NRLF) analysis in post-contingency states. Finally, the numerical results of applying the proposed approach to the IEEE 14-bus, 118-bus, and 300-bus test systems demonstrate the accuracy and rapidity of OSSA.

Yuanyuan Sun, Timothy Parker, Lara Gierschmann et al.

Emerging AI regulations assign distinct obligations to different actors along the AI value chain (e.g., the EU AI Act distinguishes providers and deployers for both AI models and AI systems), yet the foundational terms "AI model" and "AI system" lack clear, consistent definitions. Through a systematic review of 896 academic papers and a manual review of over 80 regulatory, standards, and technical or policy documents, we analyze existing definitions from multiple conceptual perspectives. We then trace definitional lineages and paradigm shifts over time, finding that most standards and regulatory definitions derive from the OECD's frameworks, which evolved in ways that compounded rather than resolved conceptual ambiguities. The ambiguity of the boundary between an AI model and an AI system creates practical difficulties in determining obligations for different actors, and raises questions on whether certain modifications performed are specific to the model as opposed to the non-model system components. We propose conceptual definitions grounded in the nature of models and systems and the relationship between them, then develop operational definitions for contemporary neural network-based machine-learning AI: models consist of trained parameters and architecture, while systems consist of the model plus additional components including an interface for processing inputs and outputs. Finally, we discuss implications for regulatory implementation and examine how our definitions contribute to resolving ambiguities in allocating responsibilities across the AI value chain, in both theoretical scenarios and case studies involving real-world incidents.

Juntao Li, Haobin Yuan, Ling Luo et al.

Discharge medication recommendation plays a critical role in ensuring treatment continuity, preventing readmission, and improving long-term management for patients with chronic metabolic diseases. This paper present an overview of the CHIP 2025 Shared Task 2 competition, which aimed to develop state-of-the-art approaches for automatically recommending appro-priate discharge medications using real-world Chinese EHR data. For this task, we constructed CDrugRed, a high-quality dataset consisting of 5,894 de-identified hospitalization records from 3,190 patients in China. This task is challenging due to multi-label nature of medication recommendation, het-erogeneous clinical text, and patient-specific variability in treatment plans. A total of 526 teams registered, with 167 and 95 teams submitting valid results to the Phase A and Phase B leaderboards, respectively. The top-performing team achieved the highest overall performance on the final test set, with a Jaccard score of 0.5102, F1 score of 0.6267, demonstrating the potential of advanced large language model (LLM)-based ensemble systems. These re-sults highlight both the promise and remaining challenges of applying LLMs to medication recommendation in Chinese EHRs. The post-evaluation phase remains open at https://tianchi.aliyun.com/competition/entrance/532411/.

Juntao Li, Haobin Yuan, Ling Luo et al.

Intelligent drug recommendation based on Electronic Health Records (EHRs) is critical for improving for improving the quality and efficiency of clinical decision-making. By leveraging large-scale patient data, drug recommendation systems can assist physicians in selecting the most appropriate medications according to a patient's medical history, diagnoses, laboratory results, and comorbidities. However, the advancement of such systems is significantly hampered by the scarcity of publicly available, real-world EHR datasets, particularly in languages other than English. In this work, we present CDrugRed, a first publicly available Chinese drug recommendation dataset focused on discharge medications for metabolic diseases. The dataset includes 5,894 de-identified records from 3,190 patients, containing comprehensive information such as patient demographics, medical history, clinical course, and discharge diagnoses. We assess the utility of CDrugRed by benchmarking several state-of-the-art large language models (LLMs) on the discharge medication recommendation task. Experimental results show that while supervised fine-tuning improves model performance, there remains substantial room for improvement, with the best model achieving the F1 score of 0.5648 and Jaccard score of 0.4477. This result highlights the complexity of the clinical drug recommendation task and establishes CDrugRed as a challenging and valuable resource for developing more robust and accurate drug recommendation systems. The dataset is publicly available to the research community under the data usage agreements at https://github.com/DUTIR-BioNLP/CDrugRed.

Zhijun Wang, Ling Luo, Dinghao Pan et al.

Automated Drug Combination Extraction (DCE) from large-scale biomedical literature is crucial for advancing precision medicine and pharmacological research. However, existing relation extraction methods primarily focus on binary interactions and struggle to model variable-length n-ary drug combinations, where complex compatibility logic and distributed evidence need to be considered. To address these limitations, we propose RexDrug, an end-to-end reasoning-enhanced relation extraction framework for n-ary drug combination extraction based on large language models. RexDrug adopts a two-stage training strategy. First, a multi-agent collaborative mechanism is utilized to automatically generate high-quality expert-like reasoning traces for supervised fine-tuning. Second, reinforcement learning with a multi-dimensional reward function specifically tailored for DCE is applied to further refine reasoning quality and extraction accuracy. Extensive experiments on the DrugComb dataset show that RexDrug consistently outperforms state-of-the-art baselines for n-ary extraction. Additional evaluation on the DDI13 corpus confirms its generalizability to binary drugdrug interaction tasks. Human expert assessment and automatic reasoning metrics further indicates that RexDrug produces coherent medical reasoning while accurately identifying complex therapeutic regimens. These results establish RexDrug as a scalable and reliable solution for complex biomedical relation extraction from unstructured text. The source code and data are available at https://github.com/DUTIR-BioNLP/RexDrug

Tengxiao Lv, Ling Luo, Juntao Li et al.

Accurate recognition of biomedical named entities is critical for medical information extraction and knowledge discovery. However, existing methods often struggle with nested entities, entity boundary ambiguity, and cross-lingual generalization. In this paper, we propose a unified Biomedical Named Entity Recognition (BioNER) framework based on Large Language Models (LLMs). We first reformulate BioNER as a text generation task and design a symbolic tagging strategy to jointly handle both flat and nested entities with explicit boundary annotation. To enhance multilingual and multi-task generalization, we perform bilingual joint fine-tuning across multiple Chinese and English datasets. Additionally, we introduce a contrastive learning-based entity selector that filters incorrect or spurious predictions by leveraging boundary-sensitive positive and negative samples. Experimental results on four benchmark datasets and two unseen corpora show that our method achieves state-of-the-art performance and robust zero-shot generalization across languages. The source codes are freely available at https://github.com/dreamer-tx/LLMNER.

Jinzhong Ning, Paerhati Tulajiang, Yingying Le et al.

Speech Relation Extraction (SpeechRE) aims to extract relation triplets directly from speech. However, existing benchmark datasets rely heavily on synthetic data, lacking sufficient quantity and diversity of real human speech. Moreover, existing models also suffer from rigid single-order generation templates and weak semantic alignment, substantially limiting their performance. To address these challenges, we introduce CommonVoice-SpeechRE, a large-scale dataset comprising nearly 20,000 real-human speech samples from diverse speakers, establishing a new benchmark for SpeechRE research. Furthermore, we propose the Relation Prompt-Guided Multi-Order Generative Ensemble (RPG-MoGe), a novel framework that features: (1) a multi-order triplet generation ensemble strategy, leveraging data diversity through diverse element orders during both training and inference, and (2) CNN-based latent relation prediction heads that generate explicit relation prompts to guide cross-modal alignment and accurate triplet generation. Experiments show our approach outperforms state-of-the-art methods, providing both a benchmark dataset and an effective solution for real-world SpeechRE. The source code and dataset are publicly available at https://github.com/NingJinzhong/SpeechRE_RPG_MoGe.

Zewen Bai, Shengdi Yin, Junyu Lu et al.

The proliferation of hate speech has caused significant harm to society. The intensity and directionality of hate are closely tied to the target and argument it is associated with. However, research on hate speech detection in Chinese has lagged behind, and existing datasets lack span-level fine-grained annotations. Furthermore, the lack of research on Chinese hateful slang poses a significant challenge. In this paper, we provide a solution for fine-grained detection of Chinese hate speech. First, we construct a dataset containing Target-Argument-Hateful-Group quadruples (STATE ToxiCN), which is the first span-level Chinese hate speech dataset. Secondly, we evaluate the span-level hate speech detection performance of existing models using STATE ToxiCN. Finally, we conduct the first study on Chinese hateful slang and evaluate the ability of LLMs to detect such expressions. Our work contributes valuable resources and insights to advance span-level hate speech detection in Chinese.

Wei Chen, Liang Wu, Shuyi Lu et al.

Total-body PET/CT enables system-wide molecular imaging, but heterogeneous anatomical and metabolic signals, approximately 2 m axial coverage, and structured radiology semantics challenge existing medical AI models that assume single-modality inputs, localized fields of view, and coarse image-text alignment. We introduce SDF-HOLO (Systemic Dual-stream Fusion Holo Model), a multimodal foundation model for holistic total-body PET/CT, pre-trained on more than 10,000 patients. SDF-HOLO decouples CT and PET representation learning with dual-stream encoders and couples them through a cross-modal interaction module, allowing anatomical context to refine PET aggregation while metabolic saliency guides subtle morphological reasoning. To model long-range dependencies across the body, hierarchical context modeling combines efficient local windows with global attention. To bridge voxels and clinical language, we use anatomical segmentation masks as explicit semantic anchors and perform voxel-mask-text alignment during pre-training. Across tumor segmentation, low-dose lesion detection, and multilingual diagnostic report generation, SDF-HOLO outperforms strong task-specific and clinical-reference baselines while reducing localization errors and hallucinated findings. Beyond focal interpretation, the model enables system-wide metabolic profiling and reveals tumor-associated fingerprints of inter-organ metabolic network interactions, providing a scalable computational foundation for total-body PET/CT diagnostics and system-level precision oncology.

Yingpeng Ning, Yuanyuan Sun, Ling Luo et al.

Biomedical question answering (QA) requires accurate interpretation of complex medical knowledge. Large language models (LLMs) have shown promising capabilities in this domain, with retrieval-augmented generation (RAG) systems enhancing performance by incorporating external medical literature. However, RAG-based approaches in biomedical QA suffer from hallucinations due to post-retrieval noise and insufficient verification of retrieved evidence, undermining response reliability. We propose MedTrust-Guided Iterative RAG, a framework designed to enhance factual consistency and mitigate hallucinations in medical QA. Our method introduces three key innovations. First, it enforces citation-aware reasoning by requiring all generated content to be explicitly grounded in retrieved medical documents, with structured Negative Knowledge Assertions used when evidence is insufficient. Second, it employs an iterative retrieval-verification process, where a verification agent assesses evidence adequacy and refines queries through Medical Gap Analysis until reliable information is obtained. Third, it integrates the MedTrust-Align Module (MTAM) that combines verified positive examples with hallucination-aware negative samples, leveraging Direct Preference Optimization to reinforce citation-grounded reasoning while penalizing hallucination-prone response patterns.

Zewen Bai, Liang Yang, Shengdi Yin et al.

The proliferation of hate speech has inflicted significant societal harm, with its intensity and directionality closely tied to specific targets and arguments. In recent years, numerous machine learning-based methods have been developed to detect hateful comments on online platforms automatically. However, research on Chinese hate speech detection lags behind, and interpretability studies face two major challenges: first, the scarcity of span-level fine-grained annotated datasets limits models' deep semantic understanding of hate speech; second, insufficient research on identifying and interpreting coded hate speech restricts model explainability in complex real-world scenarios. To address these, we make the following contributions: (1) We introduce the Span-level Target-Aware Toxicity Extraction dataset (STATE ToxiCN), the first span-level Chinese hate speech dataset, and evaluate the hate semantic understanding of existing models using it. (2) We conduct the first comprehensive study on Chinese coded hate terms, LLMs' ability to interpret hate semantics. (3) We propose a method to integrate an annotated lexicon into models, significantly enhancing hate speech detection performance. Our work provides valuable resources and insights to advance the interpretability of Chinese hate speech detection research.

Zheng Tan, Yiwen Nie, Wenfa Wu et al.

Demand is spiking in industrial fields for multidisciplinary forecasting, where a broad spectrum of sectors needs planning and forecasts to streamline intelligent business management, such as demand forecasting, product planning, inventory optimization, etc. Specifically, these tasks expecting intelligent approaches to learn from sequentially collected historical data and then foresee most possible trend, i.e. time series forecasting. Challenge of it lies in interpreting complex business contexts and the efficiency and generalisation of modelling. With aspirations of pre-trained foundational models for such purpose, given their remarkable success of large foundation model across legions of tasks, we disseminate \leforecast{}, an enterprise intelligence platform tailored for time series tasks. It integrates advanced interpretations of time series data and multi-source information, and a three-pillar modelling engine combining a large foundation model (Le-TSFM), multimodal model and hybrid model to derive insights, predict or infer futures, and then drive optimisation across multiple sectors in enterprise operations. The framework is composed by a model pool, model profiling module, and two different fusion approaches regarding original model architectures. Experimental results verify the efficiency of our trail fusion concepts: router-based fusion network and coordination of large and small models, resulting in high costs for redundant development and maintenance of models. This work reviews deployment of LeForecast and its performance in three industrial use cases. Our comprehensive experiments indicate that LeForecast is a profound and practical platform for efficient and competitive performance. And we do hope that this work can enlighten the research and grounding of time series techniques in accelerating enterprise.

Pengfei Zuo, Yu Hua, Cong Wang et al.

Data deduplication is able to effectively identify and eliminate redundant data and only maintain a single copy of files and chunks. Hence, it is widely used in cloud storage systems to save storage space and network bandwidth. However, the occurrence of deduplication can be easily identified by monitoring and analyzing network traffic, which leads to the risk of user privacy leakage. The attacker can carry out a very dangerous side channel attack, i.e., learn-the-remaining-information (LRI) attack, to reveal users' privacy information by exploiting the side channel of network traffic in deduplication. Existing work addresses the LRI attack at the cost of the high bandwidth efficiency of deduplication. In order to address this problem, we propose a simple yet effective scheme, called randomized redundant chunk scheme (RRCS), to significantly mitigate the risk of the LRI attack while maintaining the high bandwidth efficiency of deduplication. The basic idea behind RRCS is to add randomized redundant chunks to mix up the real deduplication states of files used for the LRI attack, which effectively obfuscates the view of the attacker, who attempts to exploit the side channel of network traffic for the LRI attack. Our security analysis shows that RRCS could significantly mitigate the risk of the LRI attack. We implement the RRCS prototype and evaluate it by using three large-scale real-world datasets. Experimental results demonstrate the efficiency and efficacy of RRCS.